An Elegant Defense

National Bestseller "A valuable read that will help you understand what it takes to stop COVID-19. … A super interesting look at the science of immunity.” —Bill Gates, Gates Notes Summer Reading List The Pulitzer Prize–winning New York Times journalist "explicates for the lay reader the intricate biology of our immune system" (Jerome Groopman, MD, New York Review of Books) From New York Times science journalist Matt Richtel, An Elegant Defense is an acclaimed and definitive exploration of the immune system and the secrets of health. Interweaving cutting-edge science with the intimate stories of four individual patients, this epic, first-of-its-kind book “give[s] lay readers a means of understanding what’s known so far about the intricate biology of our immune systems” (The Week). The immune system is our body’s essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. It has been honed by evolution over millennia to face an almost infinite array of threats. For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutrition—hallmarks of modern life—and even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders. An Elegant Defense effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to today’s laboratories that are revolutionizing immunology—perhaps the most extraordinary and consequential medical story of our time. Drawing on extensive new interviews with dozens of world-renowned scientists, Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our “elegant defense.”

This book will teach you how to use word power rather than willpower to increase your motivation and overcome your struggles with eating and body care. It explains how self-talk ties thought to action or inaction and how what we say to ourselves is shaped—for better or worse—by our families, culture and personal history. It illustrates how unconscious, unhealthy self-talk leads to poor decision-making around eating, fitness and general self-care and how conscious, healthy self-talk promotes a positive relationship with food, body and mind. Words to Eat By details key elements of constructive, smart self-talk. You’ll learn how to distinguish trash thoughts from treasure thoughts, why external motivators don’t work long-term, and which internal motivators will fast track you to success. It includes hundreds of examples of exactly what to say and not say to yourself in challenging food situations—eating alone, with family, friends, dates and mates, at parties, restaurants and buffets—and how to get and keep your body moving. Reflective questions help you zero in on which self-talk you want to change, while case studies illustrate how other troubled eaters have transformed their self-talk and their lives. Written by a national expert, award-winning, international author and seasoned clinician who is also half-a-lifetime recovered from weight-loss dieting and binge-eating, this book introduces you to the nitty gritty of your eating and self-care problems and teaches you how to speak to yourself with the love, compassion, encouragement and hope needed to jump start or sustain your recovery.

"Deserves a spot next to Fast Food Nation and To Kill a Mockingbird in America’s high school curriculums. To say it may save lives is self-evident.” —New York Times Book Review (Editor's Choice) NEW YORK TIMES BESTSELLER • A BEST BOOK OF THE YEAR: San Francisco Chronicle, Chrisitian Science Monitor, Kirkus, Winnipeg Free Press One of the decade's most original and masterfully reported books, A Deadly Wandering by Pulitzer Prize–winning New York Times journalist Matt Richtel interweaves the cutting-edge science of attention with the tensely plotted story of a mysterious car accident and its aftermath to answer some of the defining questions of our time: What is technology doing to us? Can our minds keep up with the pace of change? How can we find balance? On the last day of summer, an ordinary Utah college student named Reggie Shaw fatally struck two rocket scientists while texting and driving along a majestic stretch of highway bordering the Rocky Mountains. A Deadly Wandering follows Reggie from the moment of the tragedy, through the police investigation, the state's groundbreaking prosecution, and ultimately, Reggie's wrenching admission of responsibility. Richtel parallels Reggie's journey with leading-edge scientific findings on the impact technology has on our brains, showing how these devices play to our deepest social instincts. A propulsive read filled with surprising scientific detail, riveting narrative tension, and rare emotional depth, A Deadly Wandering is a book that can change—and save—lives.

This study examines the law of intellectual property in China from imperial times to the present. It draws on history, politics, economics, sociology, and the arts, and on interviews with officials, business people, lawyers, and perpetrators and victims of 'piracy'. The author asks why the Chinese, with their early bounty of scientific and artistic creations, are only now devising legal protection for such endeavors and why such protection is more rhetoric than reality on the Chinese mainland. In the process, he sheds light on the complex relation between law and political culture in China. The book goes on to examine recent efforts in the People's Republic of China to develop intellectual property law, and uses this example to highlight the broader problems with China's program of law reform.

NEW YORK TIMES BESTSELLER • A gorgeously illustrated deep dive into the immune system that will forever change how you think about your body, from the creator of the popular science YouTube channel Kurzgesagt—In a Nutshell “Through wonderful analogies and a genius for clarifying complex ideas, Immune is a truly brilliant introduction to the human body’s vast system for fighting infections and other threats.”—John Green, #1 New York Times bestselling author of The Fault in Our Stars You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. But most of us never really stop to ask: What even is our immune system? Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defenses. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you’ve been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body. Each chapter delves into an element of the immune system, including defenses like antibodies and inflammation as well as threats like bacteria, allergies, and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body’s defenses, how viruses work, and what goes on in your wounds when you cut yourself. Enlivened by engaging full-color graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects—immunology—into a gripping adventure through an astonishing alien landscape. Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body.

"Remarkable. This profound volume informs and inspires." —PW, STARRED review From the Pulitzer Prize–winning New York Times science reporter acclaimed for “bring[ing] scientific concepts to life” (Bill Gates), a pathbreaking new investigation into the mysteries of human creativity How does creativity work? Where does inspiration come from? What are the secrets of our most revered creators? How can we maximize our creative potential? THIS IS THE STORY OF HOW WE CREATE. Creativity defines the human experience. It sparks achievement and innovation in art, science, technology, business, sports, and virtually every activity. It has fueled human progress on a global level, but it equally is the source of profound personal satisfaction for individual creators. And yet the origins of creative inspiration and the methods by which great creators tap into it have long been a source of mystery, spoken of in esoteric terms, our rational understanding shrouded in complex jargon. Until now. Inspired is a book about the science of creativity, distilling an explosion of exciting new research from across the world. Through narrative storytelling, Richtel marries these findings with timeless insight from some of the world’s great creators as he deconstructs the authentic nature of creativity, its biological and evolutionary origins, its deep connection to religion and spirituality, the way it bubbles in each of us, urgent and essential, waiting to be tapped. Many of the questions Richtel addresses are practical: What are the traits of successful creators? Under which conditions does creativity thrive? How can we move past creative blocks? The ultimate message of Inspired is that creativity is more accessible than many might imagine, as necessary, beautiful, and fulfilling as any essential part of human nature.

“MICHAEL CRICHTON meets STEPHEN KING at their finest … with the creepiest opening I’ve ever read.” — Lisa Gardner * “Joins the ranks of classic paranoid thrillers about human achievement run amok, with STEPHEN KING’s The Stand and Michael Crichton’s Terminal Man.” — Joseph Finder * “A heart-stopping thriller. … a must-read for MICHAEL CRICHTON fans.” — Dallas Morning News * “Similar in atmosphere and style to MICHAEL CRICHTON and STEPHEN KING. ... A race-against-the-clock thriller.” — Booklist FLIGHT 194 LANDED. SOMETHING LETHAL AWAITS OUTSIDE. THIS IS DEAD ON ARRIVAL. An airplane touches down at a desolate airport in a remote Colorado ski town. Shortly after landing, Dr. Lyle Martin, a world-class infectious disease specialist, is brusquely awakened to shocking news: Everyone not on the plane appears to be dead. The world has gone dark. While they were in the air, a lethal new kind of virus surfaced, threatening mankind's survival, and now Martin—one of the most sought-after virologists on the planet until his career took a precipitous slide—is at the center of the investigation. Moving at lightning pace from the snowbound Rockies to the secret campus of Google X, where unlimited budgets may be producing wonders beyond our capacity to control, Dead on Arrival is a brilliantly imaginative, intricately plotted thriller that draws on Matt Richtel's years of science and technology reporting for the New York Times, and establishes him as one of the premier thriller writers working today.

Pretentiousness is the engine oil of culture; the essential lubricant in the development of all arts, high, low, or middle.