An Introduction To Tissue Biomaterial Interactions

An Introduction to Tissue-Biomaterial Interactions acquaintsan undergraduate audience with the fundamental biological processesthat influence these sophisticated, cutting-edge procedures.Chapters one through three provide more detail about themolecular-level events that happen at the tissue-implant interface,while chapters four through ten explore selected material,biological, and physiological consequences of these events. Theimportance of the body’s wound-healing response is emphasizedthroughout. Specific topics covered include:Structure andproperties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples oftissue-biomaterial interactions The text also provides extensive coverage of the three pertinentinterfaces between the body and the biomaterial, between the bodyand the living cells, and between the cells and the biomaterialthat are critical in the development of tissue-engineered productsthat incorporate living cells within a biomaterial matrix. Idealfor a one-semester, biomedical engineering course, An Introductionto Tissue-Biomaterial Interactions provides a solid framework forunderstanding today’s and tomorrow’s implantablebiomedical devices.

Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.

Introductory Biomaterials enables undergraduate students in Biomedical, Chemical, Materials and other relevant Engineering disciplines to become familiar with the key concepts of Biomaterials principles: biocompatibility, structure-property-applications relationships, mechanical response of natural tissues, and cellular pathways for tissue-material ingrowth. Written in a clear, concise manner that weds theory with applications, this book helps students to understand the often intricate relationships between materials the implant devices that are made from them, and how the human body reacts to them. The book includes such concepts as requirements for metals, alloys, and ceramic materials to be used in load bearing implants (corrosion concepts, stress shielding, mechanical properties, composition), what properties of polymers impact their use in medicine (leaching and swelling, creep and stress relaxation); the tissue response to biomaterials, concepts related to drug delivery applications (polymer degradation, encapsulation), and tissue engineering (scaffold porosity, diffusion of nutrients, mechanical properties). Begins with structure-properties, followed immediately by their impact on actual biomaterials classes and devices, thus directly relating theory to applications (e.g. polymers to polymeric stents; metals to fracture fixation devices) Explains concepts in a clear, progressive manner, with numerous examples and figures to enhance student learning Covers all key biomaterials classes: metallic, ceramic, polymeric, composite and biological Includes a timely chapter on medical device regulation

The second edition of this bestselling title provides the most up-to-date comprehensive review of all aspects of biomaterials science by providing a balanced, insightful approach to learning biomaterials. This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials. Provides comprehensive coverage of principles and applications of all classes of biomaterials Integrates concepts of biomaterials science and biological interactions with clinical science and societal issues including law, regulation, and ethics Discusses successes and failures of biomaterials applications in clinical medicine and the future directions of the field Cover the broad spectrum of biomaterial compositions including polymers, metals, ceramics, glasses, carbons, natural materials, and composites Endorsed by the Society for Biomaterials

A succinct introduction to the field of biomaterials engineering, packed with practical insights.

This succinct textbook gives students the perfect introduction to the world of biomaterials, linking the fundamental properties of metals, polymers, ceramics and natural biomaterials to the unique advantages and limitations surrounding their biomedical applications. Clinical concerns such as sterilization, surface modification, cell-biomaterial interactions, drug delivery systems and tissue engineering are discussed in detail, giving students practical insight into the real-world challenges associated with biomaterials engineering; key definitions, equations and concepts are concisely summarised alongside the text, allowing students to quickly and easily identify the most important information; and bringing together elements from across the book, the final chapter discusses modern commercial implants, challenging students to consider future industrial possibilities. Concise enough to be taught in a single semester, and requiring only a basic understanding of biology, this balanced and accessible textbook is the ideal introduction to biomaterials for students of engineering and materials science.

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers