Bacterial Cellular Metabolic Systems

Bacterial Cellular Metabolic Systems
Author: K. Shimizu
Publsiher: Elsevier
Total Pages: 496
Release: 2013-03-26
Genre: Science
ISBN: 9781908818201

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The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism. Comprehensive account of metabolic regulation via global regulators in response to changes in the culture environment Basic formulation of 13C-metabolic flux analysis based on 13C-labelling experiments Systems biology approach for the modelling and computer simulation of the main metabolic pathways of a cell system

Bacterial Metabolism

Bacterial Metabolism
Author: H. W. Doelle
Publsiher: Academic Press
Total Pages: 752
Release: 2014-06-28
Genre: Nature
ISBN: 9781483272375

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Bacterial Metabolism, Second Edition describes microbial systematics and microbial chemistry and focuses on catabolic events. This book deals with the progress made in bacterial metabolism that includes data on regulatory mechanisms; comparison of bacterial growth kinetics with enzyme kinetics; aerobic amino acid catabolism; and the glucose transport mechanism. This text also emphasizes the development of photosynthetic phosphorylation in the different bacterial families. This book explains anaerobic respiration and carbohydrate metabolism—glucose, fructose, lactose, mannose, allose, and sorbitol. This text then describes aerobic respiration including the "Nitroso" and "Nitro" groups of genera, and the Knallgas bacteria, which use the reaction between molecular hydrogen and molecular oxygen as their source of energy. This book also explains the microbial transformation of iron as caused by either specific organisms (e.g. Ferrobacillus ferrooxidans) or nonspecific organisms. This selection also explains the process of fermentation by Enterobacteriaceae, lactic acid bacteria, and proteolytic clostridia. This text can be valuable for microchemists, microbiologists, students, and academicians whose disciplines are in biological chemistry and cellular biology.

Bacterial Metabolism

Bacterial Metabolism
Author: Gerhard Gottschalk
Publsiher: Springer Science & Business Media
Total Pages: 378
Release: 1986
Genre: Medical
ISBN: 9780387961538

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I am particularly indebted to Joan Macy, Lynne Quandt, Jan Andreesen and Peter Hillmer for reading the manuscript, for their criticisms and their suggestions, and I thank Ute Gnass for typing the manuscript and for her invaluable help with the indexing and with the preparation of the figures. Finally, I am grateful to the publishers for their patience, willing help, and cooperation. G6ttingen, 1978 GERHARD GOTTSCHALK Contents CHAPTER I Nutrition of Bacteria I. Major and Minor Bioelements I II. The Two Basic Mechanisms of ATP Synthesis 4 III. Nutrients as Energy Sources 6 IV. Growth Factor Requirements of Bacteria 9 V. Summary 10 CHAPTER 2 How Escherichia coli Synthesizes ATP during Aerobic Growth on Glucose I. Transport of D-Glucose into the E. coli Cell 13 II. Degradation of Glucose-6-Phosphate to Pyruvate via the Embden-Meyerhof- Parnas (EMP) Pathway 15 III. Oxidative Decarboxylation of Pyruvate to Acetyl-Coenzyme A 18 IV. Oxidation of Acetyl-CoA via the Tricarboxylic Acid Cycle 20 V. The Formation of ATP in the Respiratory Chain 22 VI. Summary 35 CHAPTER 3 Biosynthesis of Escherichia coli Cells from Glucose I. Composition of E. coli Cells 38 II. Assimilation of Ammonia 40 Ill. Assimilatory Reduction of Sulfate 42 IV. Biosynthesis of Amino Acids 43 V. How Pentose Phosphates and NADPH are Formed 55 xii Contents VI. Ribonucleotides and Deoxyribonucleotides 59 VII. Biosynthesis of Lipids 65 VIII. Formation of Carbohydrates 71 IX. Synthesis of Polymers 73 X. The Requirement for an Anaplerotic Sequence 92 XI.

Molecular Biology of The Cell

Molecular Biology of The Cell
Author: Bruce Alberts
Publsiher: Unknown
Total Pages: 0
Release: 2002
Genre: Cytology
ISBN: 0815332181

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Microbial Metabolism and Disease

Microbial Metabolism and Disease
Author: Elena L. Paley
Publsiher: Academic Press
Total Pages: 308
Release: 2021-03-13
Genre: Science
ISBN: 9780323884464

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Microbiome Metabolic Pathways and Disease provides insight into the interaction of microbial metabolic pathways in the human body and the impact these can have on a variety of diseases. By analyzing these pathways the book seeks to investigate how these metabolic processes can be targeted and manipulated in order to treat various disorders and diseases. Topics covered in the book include microbial shikimate pathways, protein biosynthesis, tryptophan metabolites, microbiome metabolic engineering, fecal microbiota transplantation, and virulence factors. Additionally, a variety of conditions are covered, such as disorders associated with metabolic syndromes, serotonin syndromes, Alzheimer’s disease, and Covid-19, providing a detailed overview of how metabolic pathways of microbiome can impact health and disease in the human body. Explores microbial metabolic pathways in the human body and implications for disease Investigates specific steps involved in metabolic reactions in the human microbiome, including shikimate pathways and tryptophan pathways Considers a variety of diseases and disorders, such as Alzheimer’s disease, metabolic syndromes, Crohn’s disease and Covid-19 Includes analysis of various amino acids and enzymes in microbial and human cells and how these can impact health

Bacterial Physiology and Metabolism

Bacterial Physiology and Metabolism
Author: Byung Hong Kim,Geoffrey Michael Gadd
Publsiher: Cambridge University Press
Total Pages: 933
Release: 2008-02-21
Genre: Science
ISBN: 9781139467629

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Recent determination of genome sequences for a wide range of bacteria has made in-depth knowledge of prokaryotic metabolic function essential in order to give biochemical, physiological, and ecological meaning to the genomic information. Clearly describing the important metabolic processes that occur in prokaryotes under different conditions and in different environments, this advanced text provides an overview of the key cellular processes that determine bacterial roles in the environment, biotechnology, and human health. Prokaryotic structure is described as well as the means by which nutrients are transported into cells across membranes. Glucose metabolism through glycolysis and the TCA cycle are discussed, as well as other trophic variations found in prokaryotes, including the use of organic compounds, anaerobic fermentation, anaerobic respiratory processes, and photosynthesis. The regulation of metabolism through control of gene expression and control of the activity of enzymes is also covered, as well as survival mechanisms used under starvation conditions.

Size Limits of Very Small Microorganisms

Size Limits of Very Small Microorganisms
Author: National Research Council,Division on Engineering and Physical Sciences,Space Studies Board,Commission on Physical Sciences, Mathematics, and Applications,Steering Group for the Workshop on Size Limits of Very Small Microorganisms
Publsiher: National Academies Press
Total Pages: 164
Release: 1999-09-13
Genre: Science
ISBN: 0309172748

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How small can a free-living organism be? On the surface, this question is straightforward-in principle, the smallest cells can be identified and measured. But understanding what factors determine this lower limit, and addressing the host of other questions that follow on from this knowledge, require a fundamental understanding of the chemistry and ecology of cellular life. The recent report of evidence for life in a martian meteorite and the prospect of searching for biological signatures in intelligently chosen samples from Mars and elsewhere bring a new immediacy to such questions. How do we recognize the morphological or chemical remnants of life in rocks deposited 4 billion years ago on another planet? Are the empirical limits on cell size identified by observation on Earth applicable to life wherever it may occur, or is minimum size a function of the particular chemistry of an individual planetary surface? These questions formed the focus of a workshop on the size limits of very small organisms, organized by the Steering .Group for the Workshop on Size Limits of Very Small Microorganisms and held on October 22 and 23, 1998. Eighteen invited panelists, representing fields ranging from cell biology and molecular genetics to paleontology and mineralogy, joined with an almost equal number of other participants in a wide-ranging exploration of minimum cell size and the challenge of interpreting micro- and nano-scale features of sedimentary rocks found on Earth or elsewhere in the solar system. This document contains the proceedings of that workshop. It includes position papers presented by the individual panelists, arranged by panel, along with a summary, for each of the four sessions, of extensive roundtable discussions that involved the panelists as well as other workshop participants.

Microbial Cell Factories Engineering for Production of Biomolecules

Microbial Cell Factories Engineering for Production of Biomolecules
Author: Vijai Singh
Publsiher: Academic Press
Total Pages: 490
Release: 2021-02-13
Genre: Science
ISBN: 9780128214787

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Microbial Cell Factories Engineering for Production of Biomolecules presents a compilation of chapters written by eminent scientists worldwide. Sections cover major tools and technologies for DNA synthesis, design of biosynthetic pathways, synthetic biology tools, biosensors, cell-free systems, computer-aided design, OMICS tools, CRISPR/Cas systems, and many more. Although it is not easy to find relevant information collated in a single volume, the book covers the production of a wide range of biomolecules from several MCFs, including Escherichia coli, Bacillus subtilis, Pseudomonas putida, Streptomyces, Corynebacterium, Cyanobacteria, Saccharomyces cerevisiae, Pichia pastoris and Yarrowia lipolytica, and algae, among many others. This will be an excellent platform from which scientific knowledge can grow and widen in MCF engineering research for the production of biomolecules. Needless to say, the book is a valuable source of information not only for researchers designing cell factories, but also for students, metabolic engineers, synthetic biologists, genome engineers, industrialists, stakeholders and policymakers interested in harnessing the potential of MCFs in several fields. Offers basic understanding and a clear picture of various MCFs Explains several tools and technologies, including DNA synthesis, synthetic biology tools, genome editing, biosensors, computer-aided design, and OMICS tools, among others Harnesses the potential of engineered MCFs to produce a wide range of biomolecules for industrial, therapeutic, pharmaceutical, nutraceutical and biotechnological applications Highlights the advances, challenges, and future opportunities in designing MCFs