Binary Star Discoveries In The Urat1 Catalog

Data mining using the recently published First U.S. Naval Observatory Astrometric Robotic Telescope Catalog (URAT1) has yielded over 1350 common proper motion binary star systems that appear to be new discoveries.

Data mining using the recently published First U.S. Naval Observatory Astrometric Robotic Telescope Catalog (URAT1) has allowed the identification over 9400 common proper motion binary star systems many of which appear to be new discoveries.

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

A trustworthy clinical companion, the textbook offers best practice and management strategies for these common joint diseases. Formerly published as Osteoarthritis, the extensively revised third edition of the Oxford Textbook of Osteoarthritis and Crystal Arthropathy provides up-to-date and evidence-based guidance on how to assess, diagnose, and manage patients. A prestigious and international author team ensure information is expert and relevant-this is a practical tool for clinicians managing people with osteoarthritis, gout, and other crystal-associated arthritis. Confidently consider and chose the right blend of treatment for your patient, whether physical, pharmacological, surgical, or supportive. The Oxford Textbook of Osteoarthritis and Crystal Arthropathy provides full coverage of joint failure, and includes detailed sections on epidemiology, risk factors, clinical assessment, and investigations. This edition also now includes new sections on gout and other crystal arthropathies. Clinically relevant and easily understandable overviews of basic science, including pathology and pain physiology, along with critical appraisal of current guidelines, make this a highly valuable resource. Significant coverage is also given to patient education and the involvement of the patient in management planning. Also highly illustrated, the textbook is a strong reference tool with summary boxes and key points at the end of chapters making it easy to find information quickly and help you deliver the optimum patient outcome. The textbook equips rheumatologists and musculoskeletal health professionals with the knowledge to provide best possible patient care.

One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.

The Juno mission to Jupiter is one of the most ambitious, daring and challenging solar system exploration missions ever conceived. Next to the Sun, Jupiter is the largest object in our solar system. As such, it is both a record and driver of the formation and evolution of the planets -- no other object in our solar system can tell us more about the origin of planetary systems. Understanding the details of giant planet formation, structure, composition and powerful magnetospheric environment required a new perspective close up and over the poles of Jupiter -- an orbit never before attempted. Juno was specifically designed for this challenge, entering into the harshest planetary environment known in the solar system. This volume describes the mission design, scientific strategies and instrument payload that enable Juno to peer deep into Jupiter’s atmosphere and reveal the fundamental process of the formation and early evolution of our solar system. In these papers, the Juno instrument teams describe their investigations, which include gravity radio science, microwave radiometers, magnetometers, an infrared imager auroral mapper, an ultraviolet imager and spectrograph, a visible light imager known as JunoCam, low and high energy particle detectors and plasma wave and radio electromagnetic sensors. The articles also describe a radiation monitoring experiment and the extensive laboratory measurements undertaken to assist with the analysis and interpretation of Juno’s pioneering investigation of Jupiter’s deep atmosphere. Originally published in Space Science Reviews, Volume 213, Issue 1-4, November 2017

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Tools for amateur astronomers who wish to go beyond CCD imaging and step into ‘serious’ science. The text offers techniques for gathering, analyzing, and publishing data, and describes joint projects in which amateurs and students can take part. Readers learn to recognize and avoid common errors in gathering photometry data, with detailed examples for analysis. Includes reviews of available software, with screen shots and useful tips.