Bioactive Microbial Metabolites

Bioactive microbial metabolites play an important role in expanding the market of antibiotics, food, and agriculture but also offer eco-friendly, safer, and profitable solutions to respective industries. Bioactive microbial metabolites Scope and Challenges searches out specific features and discusses future research of microbial metabolites with a wide perspective. Bioactive Microbial Metabolites: Scope and Challenges not only focuses on the identification, separation, and purification of bioactive metabolites, but also provides understanding of metabolic pathways for bioactive metabolites production that plays an important role in modern healthcare as frontline treatments for many diseases. Bioactive Microbial Metabolites: Scope and Challenges is a valuable reference for research students, academicians, and scientists in environmental microbiology and biotechnology and Industry personnel related to microbiology/ biotechnology.

In response to the field's need for an introductory text, the authors have distilled the vast and scattered literature relating to the biotechnology of microbial secondary metabolites. General biology, biosynthesis, the search for novel metabolites, and techniques for strain improvement are all discussed to provide undergraduate and graduate students with a concise, readable overview of the field.

This volume summarizes major approaches and recent developments in the research on new bioactive metabolites of microbial origin including target-directed screening strategies, evaluation of new drugs, biosynthesis, genetic manipulation, and semisynthesis. Particular attentonis given to new microbial sources of drugs, new approaches towards directed screening, advances and future perspectives in antimicrobial, antineoplastic and phytoeffectory agents, and enzyme inhibitors as pharmacological agents. The contributions represent comprehensive surveys written by recognized scientists active in their fields of research. Together, they give an interdisciplinary view which focusses on exploitation of available microbial sources for drug development, problems of evaluation, mode of action, biosynthesis and application. The book will be of interest to scientists working in microbiology, pharmacology, pharmaceutical chemistry and pharmaceutical biotechnology.

This book deals with the noteworthy advancement in the production of bioactive metabolites from microbes and their pharmacological significance. It highlights the pharmacological potential of marine microbes and endophytic fungi and their bioactive secondary metabolites. Emphasis is also given on the significance of probiotics and their specialized molecules in human health and disease as well as their role in dietary intervention for reducing the risk of non-alcoholic fatty liver disease. This work also serves as excellent reference material for researchers, students and academicians in the field of natural product chemistry, pharmacology and applied microbiology.

Volatiles and Metabolites of Microbes compiles the latest research and advancement in the field of volatiles, metabolites synthesized from the microbial strains such as actinomycetes, bacteria, cyanobacteria, and fungal species and their potential applications in the field of healthcare issue and sustainable agriculture. There is an urgent need to explore new and advanced biological methods for health industries and sustainable agriculture and to protect the environment from environmental pollution or contaminates, global warming, and also control the health of human beings from the side effects of various pharmaceuticals products. Focusing all these factors, Volatiles and Metabolites of Microbes explores new aspects of microorganism in terms of volatiles, enzymes, bioactive compounds synthesized from the microbes and their potential applications in the field of sustainable agriculture and health-related issues Provides a broad aspect about volatiles, bioactive compounds, and secondary metabolites of microbes compiled in one cover Gives the latest research and advancement in the field of volatiles, secondary metabolites, and bioactive compounds synthesized from the different microbial strains Responds to new developments in the detection of the complex compound structures of volatiles Offers insight to a very broad audience in Biotechnology, Applied Microbiology, Agronomy, and Pathology

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The biosynthetic origin of the $meta$-C$\sb7$N unit of the naphthoquinoid chromophore of the streptovaricins was shown to be 3-amino-5-hydroxybenzoic acid (AHBA) through carbon-14 and carbon-13 labeling studies. ($Carboxy$-$\sp{14}$C) AHBA was incorporated at a rate of 0.1% into streptovaricin C, and ($carboxy$-$\sp{13}$C) AHBA gave an enrichment factor of 21 for the resonance corresponding to the C-21 carbonyl in the $\sp{13}$C NMR spectrum of labeled streptovaricin C. The optimization of incorporation of labeled glucose and the production of mutants of Streptomyces spectabilis are also discussed. A detailed analysis of the $\sp1$H and $\sp{13}$C NMR spectra of streptovaricin C is described. Two new series of metabolic products were isolated from modified culture broths of S. spectabilis. The first series of compounds were members of the aureolic acid class of antibiotics and were trivially named the spectomycins. The compounds were isolated as monomeric and dimeric forms of the same chromophore structure. The second series of compounds proved to be cyclic depsipeptides that were closely related to the monamycins, but differed from the latter by one oxygen atom. The new compounds were trivially named the deoxymonamycins. The synthesis of the iron-chelating siderophore pyochelin, isolated from Pseudomonas aeruginosa, was reinvestigated, and a significant improvement in the overall yield of four of the eight possible diastereomers of the compound was realized. The relative and absolute stereochemistry of the four diastereomers was assigned through a combination of spectroscopic, crystallographic, and chemical analyses.