Biological Interactions on Materials Surfaces

Biological Interactions on Materials Surfaces
Author: David A. Puleo,Rena Bizios
Publsiher: Springer Science & Business Media
Total Pages: 429
Release: 2009-06-26
Genre: Technology & Engineering
ISBN: 0387981616

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Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.

Surface Modification of Biomaterials

Surface Modification of Biomaterials
Author: Rachel Williams
Publsiher: Elsevier
Total Pages: 438
Release: 2010-11-25
Genre: Medical
ISBN: 9780857090768

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The surface modification of biomaterials plays a significant role in determining the outcome of biological-material interactions. With the appropriate modification a material’s surface can be tailored to improve biocompatibility, adhesion and cell interactions. Consequently surface modification is vital in the development and design of new biomaterials and medical devices. Surface modification of biomaterials reviews both established surface modifications and those still in the early stages of research and discusses how they can be used to optimise biological interactions and enhance clinical performance.Part one begins with chapters looking at various types and techniques of surface modification including plasma polymerisation, covalent binding of poly (ethylene glycol) (PEG), heparinisation, peptide functionalisation and calcium phosphate deposition before going on to examine metal surface oxidation and biomaterial surface topography to control cellular response with particular reference to technologies, cell behaviour and biomedical applications. Part two studies the analytical techniques and applications of surface modification with chapters on analysing biomaterial surface chemistry, surface structure, morphology and topography before moving onto discuss modifying biomaterial surfaces to optimise interactions with blood, control infection, optimise interactions with soft tissues, repair and regenerate nerve cells, control stem cell growth and differentiation and to optimise interactions with bone.The distinguished editor and international team of contributors to Surface modification of biomaterials have produced a unique overview and detailed chapters on a range of surface modification techniques which will provide an excellent resource for biomaterials researchers and scientists and engineers concerned with improving the properties of biomaterials. It will also be beneficial for academics researching surface modification. Reviews both established surface modifications and those still in the early stages of research and how they can be used to optimise biological interactions and enhance clinical performance Studies analytical techniques and applications of surface modification with chapters assessing biomaterial surface chemistry, surface structure, morphology and topography Discusses modifying biomaterial surfaces to optimise interactions with blood and soft tissues and also to repair and regenerate nerve cells and control infection

An Introduction to Tissue Biomaterial Interactions

An Introduction to Tissue Biomaterial Interactions
Author: Kay C. Dee,David A. Puleo,Rena Bizios
Publsiher: John Wiley & Sons
Total Pages: 248
Release: 2003-04-14
Genre: Science
ISBN: 9780471461128

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An Introduction to Tissue-Biomaterial Interactions acquaintsan undergraduate audience with the fundamental biological processesthat influence these sophisticated, cutting-edge procedures.Chapters one through three provide more detail about themolecular-level events that happen at the tissue-implant interface,while chapters four through ten explore selected material,biological, and physiological consequences of these events. Theimportance of the body’s wound-healing response is emphasizedthroughout. Specific topics covered include:Structure andproperties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples oftissue-biomaterial interactions The text also provides extensive coverage of the three pertinentinterfaces between the body and the biomaterial, between the bodyand the living cells, and between the cells and the biomaterialthat are critical in the development of tissue-engineered productsthat incorporate living cells within a biomaterial matrix. Idealfor a one-semester, biomedical engineering course, An Introductionto Tissue-Biomaterial Interactions provides a solid framework forunderstanding today’s and tomorrow’s implantablebiomedical devices.

Biological Interactions with Surface Charge in Biomaterials

Biological Interactions with Surface Charge in Biomaterials
Author: Syed A. M. Tofail
Publsiher: Royal Society of Chemistry
Total Pages: 291
Release: 2011-11
Genre: Medical
ISBN: 9781849731850

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When a biomaterial is placed inside the body, a biological response is triggered almost instantaneously. With devices that need to remain in the body for long periods, such interactions can cause encrustation, plaque formation and aseptic loosening on the surface. These problems contribute to the patient's trauma and increase the risk of death. Electrical properties, such as local electrostatic charge distribution, play a significant role in defining biological interactions, although this is often masked by other factors. This book describes the fundamental principles of this phenomenon before providing a more detailed scientific background. It covers the development of the relevant technologies and their applications in therapeutic devices such as MRSA-resistant fabrics, cardiovascular and urological stents, orthopaedic implants, and grafts. Academic and graduate students interested in producing a selective biological response at the surface of a given biomaterial will find the detailed coverage of interactions at the nanometre scale useful. Practitioners will also benefit from guidance on how to pre-screen many inappropriate designs of biomedical devices long before any expensive, animal or potentially risky clinical trials. Enhanced by the use of case studies, the book is divided in to four topical sections. The final section is dedicated to the application of related topics making the book unique in its pragmatic approach to combining high end interdisciplinary scientific knowledge with commercially viable new technologies. Contributing to the newly emerging discipline of 'nanomedicine', the book is written not only by experts from each relevant specialty but also by practitioners such as clinicians and device engineers from industry.

Switchable and Responsive Surfaces and Materials for Biomedical Applications

Switchable and Responsive Surfaces and Materials for Biomedical Applications
Author: Johnathan Zhang
Publsiher: Elsevier
Total Pages: 324
Release: 2014-12-11
Genre: Technology & Engineering
ISBN: 9780857097170

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Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material "smart" and "intelligent". Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics. Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors. A comprehensive overview of switchable and responsive materials and surfaces Includes in depth analysis of thermo-responsive polymers, photonic sensitive materials and peptide-based surfaces Detailed exploration of biological interactions of responsive and switchable surfaces, covering stimuli-sensitive polymers for drug delivery, surfaces with proteins/cells and application of polymers in medical devices

Superhydrophobic Surfaces

Superhydrophobic Surfaces
Author: Russell J. Crawford,Elena P. Ivanova
Publsiher: Elsevier
Total Pages: 180
Release: 2015-02-19
Genre: Science
ISBN: 9780128013311

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Superhydrophobic Surfaces analyzes the fundamental concepts of superhydrophobicity and gives insight into the design of superhydrophobic surfaces. The book serves as a reference for the manufacturing of materials with superior water-repellency, self-cleaning, anti-icing and corrosion resistance. It thoroughly discusses many types of hydrophobic surfaces such as natural superhydrophobic surfaces, superhydrophobic polymers, metallic superhydrophobic surfaces, biological interfaces, and advanced/hybrid superhydrophobic surfaces. Provides an adequate blend of complex engineering concepts with in-depth explanations of biological principles guiding the advancement of these technologies Describes complex ideas in simple scientific language, avoiding overcomplicated equations and discipline-specific jargon Includes practical information for manufacturing superhydrophobic surfaces Written by experts with complementary skills and diverse scientific backgrounds in engineering, microbiology and surface sciences

Biological Fluid Surface Interactions in Detection and Medical Devices

Biological Fluid Surface Interactions in Detection and Medical Devices
Author: Michael Thompson,Christophe Blaszykowski,Sonia Sheikh,Cesar Rodriguez-Emmenegger,Andres de los Santos Pereira
Publsiher: Royal Society of Chemistry
Total Pages: 304
Release: 2017
Genre: Science
ISBN: 9781782620976

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With development of implants and in vivo detection devices comes the complication of the interaction between the materials used in the devices and biological fluids. This book examines these interactions causing fouling in biosensors and the serious issue of thrombus formation. The chemistry of surface-protein and surface-cell interactions is considered, the coatings and strategies re the avoidance of fouling are compared and the expert contributors provide a comprehensive look at the physical chemistry of the implant surface and the fouling problem. Finishing with a discussion of the future for surface modified biosensors in point-of-care devices and microfluidic technologies, this book provides an important addition to the literature suitable for professional researchers in academia and industry and postgraduate students.

Biomaterials Surface Science

Biomaterials Surface Science
Author: Andreas Taubert,Joao F. Mano,José Carlos Rodríguez-Cabello
Publsiher: John Wiley & Sons
Total Pages: 616
Release: 2013-07-23
Genre: Science
ISBN: 9783527649624

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At the interface of biology, chemistry, and materials science, this book provides an overview of this vibrant research field, treating the seemingly distinct disciplines in a unified way by adopting the common viewpoint of surface science. The editors, themselves prolific researchers, have assembled here a team of top-notch international scientists who read like a "who's who" of biomaterials science and engineering. They cover topics ranging from micro- and nanostructuring for imparting functionality in a top-down manner to the bottom-up fabrication of gradient surfaces by self-assembly, from interfaces between biomaterials and living matter to smart, stimuli-responsive surfaces, and from cell and surface mechanics to the elucidation of cell-chip interactions in biomedical devices. As a result, the book explains the complex interplay of cell behavior and the physics and materials science of artificial devices. Of equal interest to young, ambitious scientists as well as to experienced researchers.