Central Regulation Of The Endocrine System

According to the classical concept of Geoffrey Harris the pituitary gland is controlled by the brain by means of blood-borne chemical messengers produced by central neurons. The recent isolation and structural characterization of several such messengers by Roger Guillemin and Andrew Schally and their collaborators brought the final proof for this hypothesis. This also meant that the extensive knowledge collected in the field of neurobiology now became highly relevant for the endocrinologists. For this reason it was felt important to organize a symposium which brought together experts in the fields of neurobiology and endocrinology. The idea was to focus the attention on neuronal mechanisms, particularly those related to chemical transmission, which may be of importance for the central regulation of hormonal secretion patterns. We would like to express our sincere gratitude to the Nobel Founda tion for supporting the organization of the Nobel Symposium 42 on "Principles of the Central Regulation of the Endocrine System". We would also like to express our thanks to all participants, to Professor Carl-Gustaf Bernhard, Permanent Secretary of the Royal Academy of Sciences, for making the facilities of the Academ- available to us, and to the Symposium secretaries Mrs. Gun Hultgren, Mrs. Lena Persson and Mrs. Ulla-Britt Wedin. It is a pleasure to acknowledge the generous financial support from the Nobel Foundation and its Nobel Symposium Committee through grants from the Tercentenary Foundation of the Bank of Sweden, and from the Swedish Medical Research Council, KABI AB, Stockholm, and ASTRA AB, Sodertalje.

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field

A panel of leading experts integrate the latest findings from basic and clinical science to create a comprehensive treatment of the processes by which the brain acts as an endocrine organ, not only to control hormonal functions, but also to maintain homeostasis and regulate behavior. The authors-recognized both as leaders in their fields and as skilled teachers-provide systematic coverage of the analytical, anatomical, functional, clinical, and pathological aspects of neuroendocrinology. Topics range from the interactions between the nervous and endocrine systems to the regulation of reproduction, development, metabolism, fluid balance, and biological rhythms. Neuroendocrinology in Physiology and Medicine offers an unprecedented marriage of clinical and basic knowledge that has been missing from classical neuroscience, endocrinology, and physiology texts. It will teach today's medical students and serve researchers as a valuable reference to this rapidly growing field.