Translational and Experimental Clinical Research

Translational and Experimental Clinical Research
Author: Daniel P. Schuster,William J. Powers (MD.)
Publsiher: Lippincott Williams & Wilkins
Total Pages: 520
Release: 2005
Genre: Medical
ISBN: 0781755654

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This volume is a comprehensive textbook for investigators entering the rapidly growing field of translational and experimental clinical research. The book offers detailed guidelines for designing and conducting a study and analyzing and reporting results and discusses key ethical and regulatory issues. Chapters address specific types of studies such as clinical experiments in small numbers of patients, pharmacokinetics and pharmacodynamics, and gene therapy and pharmacogenomic studies. A major section describes modern techniques of translational clinical research, including gene expression, identifying mutations and polymorphisms, cloning, transcriptional profiling, proteomics, cell and tissue imaging, tissue banking, evaluating substrate metabolism, and in vivo imaging.

Translational Interventional Radiology

Translational Interventional Radiology
Author: Adam E.M. Eltorai,Tao Liu,Rajat Chand,Sanjeeva P. Kalva
Publsiher: Elsevier
Total Pages: 600
Release: 2023-04-05
Genre: Science
ISBN: 9780128230558

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Translational Interventional Radiology, a volume in the Handbook for Designing and Conducting Clinical and Translational Research series, covers the principles of evidence-based medicine and applies these principles to the design of translational investigations in Interventional Radiology. The reader will come to fully understand important concepts including case-control study, prospective cohort study, randomized trial, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in Interventional Radiology, and know what is needed for successful collaboration. Further, this reference is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps aspiring investigators navigate challenging considerations in study design and implementation. This book provides valuable discussions of the critical appraisal of published studies in Interventional Radiology, elucidating the evaluation of the quality with respect to measuring outcomes and making effective use of all types of evidence in patient care. In short, this practical guide will be of interest to every medical researcher and interventional radiologist who has ever had a good clinical idea but not the knowledge of how to test it. Focuses on the principles of evidence-based medicine and applies these principles to the design of translational investigations within interventional radiology Provides a practical, straightforward approach that helps investigators navigate challenging considerations in study design and implementation Details discussions of the critical appraisal of published studies in interventional radiology, supporting evaluation with respect to measuring outcomes and making effective use of all types of evidence in patient care

Designing and Conducting Mixed Methods Research

Designing and Conducting Mixed Methods Research
Author: John W. Creswell,Vicki L. Plano Clark
Publsiher: SAGE Publications
Total Pages: 701
Release: 2017-08-31
Genre: Social Science
ISBN: 9781506394671

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Combining the latest thinking in the field with practical, step-by-step guidance, the Third Edition of John W. Creswell and Vicki L. Plano Clark’s Designing and Conducting Mixed Methods Research now includes seven mixed methods designs with accompanying journal articles illustrating each design. The authors walk readers through the entire research process and present updated examples from published mixed methods studies drawn from multiple disciplines. In addition, this new edition includes information about the dynamic and evolving nature of the field of mixed methods research, four additional methodological approaches, and coverage of new directions in mixed methods.

Clinical and Translational Science

Clinical and Translational Science
Author: David Robertson,Gordon H. Williams
Publsiher: Academic Press
Total Pages: 812
Release: 2016-11-25
Genre: Science
ISBN: 9780128021118

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Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Translational Surgery

Translational Surgery
Author: Anonim
Publsiher: Elsevier
Total Pages: 770
Release: 2023-03-22
Genre: Medical
ISBN: 9780323906302

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Translational Surgery covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts including case-control studies, prospective cohort studies, randomized trials, and reliability studies. Investigators will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in surgical research, and know what is needed for collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the translational research navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in surgery, allowing the reader to learn how to evaluate the quality of such studies. Thus, they will improve at measuring outcomes; making effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every surgeon or surgical researcher who has ever had a good clinical idea, but not the knowledge of how to test it. Focuses on translational research in Surgery, covering the principles of evidence-based medicine and applying those principles to the design of translational investigations Provides a practical, straightforward approach to help surgeons and researchers navigate challenging aspects of study design and implementation Details valuable discussions on the critical appraisal of published studies in Surgery, allowing the reader to effectively use all types of evidence for patient care

The Design and Conduct of Meaningful Experiments Involving Human Participants

The Design and Conduct of Meaningful Experiments Involving Human Participants
Author: R. Barker Bausell
Publsiher: Oxford University Press
Total Pages: 288
Release: 2015-01-29
Genre: Psychology
ISBN: 9780199385256

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Designing and conducting experiments involving human participants requires a skillset different from that needed for statistically analyzing the resulting data. The Design and Conduct of Meaningful Experiments Involving Human Participants combines an introduction to scientific culture and ethical mores with specific experimental design and procedural content. Author R. Barker Bausell assumes no statistical background on the part of the reader, resulting in a highly accessible text. Clear instructions are provided on topics ranging from the selection of a societally important outcome variable to potentially efficacious interventions to the conduct of the experiment itself. Early chapters introduce the concept of experimental design in an intuitive manner involving both hypothetical and real-life examples of how people make causal inferences. The fundamentals of formal experimentation, randomization, and the use of control groups are introduced in the same manner, followed by the presentation and explanation of common (and later, more advanced) designs. Replete with synopses of examples from the journal literature and supplemented by 25 experimental principles, this book is designed to serve as an interdisciplinary supplementary text for research-methods courses in the educational, psychological, behavioral, social, and health sciences. It also serves as an excellent primary text for methods seminar courses.

Introduction to Designing and Conducting Research

Introduction to Designing and Conducting Research
Author: Clifford J. Drew
Publsiher: Unknown
Total Pages: 376
Release: 1980
Genre: Reference
ISBN: WISC:89007065295

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Translational Interventional Radiology

Translational Interventional Radiology
Author: Adam E. M. Eltorai,Tao Liu,Rajat Chand,Sanjeeva P. Kalva
Publsiher: Elsevier
Total Pages: 598
Release: 2023-02-15
Genre: Science
ISBN: 9780128230268

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Designing and Conducting Translational Research: Interventional Radiology covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts including case-control study, prospective cohort study, randomized trial, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in interventional radiology, and know what is needed in collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in interventional radiology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every Medical Researcher or Interventional Radiologist who has ever had a good clinical idea but not the knowledge of how to test it. Focuses on the principles of evidence-based medicine and applies these principles to the design of translational investigations within interventional radiology Provides a practical, straightforward approach that helps investigators navigate challenging considerations in study design and implementation Details discussions of the critical appraisal of published studies in interventional radiology, supporting evaluation with respect to measuring outcomes and making effective use of all types of evidence in patient care