Double edged Swords Genetic Factors That Influence the Pathogenesis of Both Metabolic Disease and Cancer

Double edged Swords  Genetic Factors That Influence the Pathogenesis of Both Metabolic Disease and Cancer
Author: Che-Pei Kung,Maureen E. Murphy,Hua Lu
Publsiher: Frontiers Media SA
Total Pages: 130
Release: 2019-09-23
Genre: Electronic Book
ISBN: 9782889630301

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Metabolic diseases and cancers account for half of all mortalities in the world, underscoring the significance of understanding the etiology of these diseases and developing effective therapies. Genomic research in the 21st century has brought cancer and metabolic disease, two once seemingly parallel ailments, as close to each other as they’ve ever been. Many genetic factors have been found to display functions regulating both cancer and metabolic disease. In this research topic: "Double-edged Swords: Genetic Factors That Influence The Pathogenesis of Both MetabolicDisease and Cancer", you will be introduced to individual genes, as well as genetic pathways that play important roles in influencing the progression of both metabolic disease and cancer. By no means covering an exhaustive list of genes qualified, this collection of articles rather serves as a precursor of what is yet to come in biomedical research. It paints the big picture of one of the major fields contributing to the future of “precision medicine”.

Double edged swords Important factors connecting metabolic disorders and cancer development from basic research to translational applications

Double edged swords  Important factors connecting metabolic disorders and cancer development   from basic research to translational applications
Author: Che-Pei Kung,Conghui Yao,Thibaut Barnoud,Maureen Murphy
Publsiher: Frontiers Media SA
Total Pages: 139
Release: 2023-04-04
Genre: Medical
ISBN: 9782832519394

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Signal Transduction in Cancer

Signal Transduction in Cancer
Author: David A. Frank
Publsiher: Springer Science & Business Media
Total Pages: 358
Release: 2002-12-31
Genre: Medical
ISBN: 9781402073403

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One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

The Heterogeneity of Cancer Metabolism

The Heterogeneity of Cancer Metabolism
Author: Anne Le
Publsiher: Springer Nature
Total Pages: 283
Release: 2021-05-20
Genre: Medical
ISBN: 9783030657680

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This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Inflammation and Cancer

Inflammation and Cancer
Author: Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publsiher: Springer
Total Pages: 490
Release: 2014-05-12
Genre: Medical
ISBN: 9783034808378

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This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Nutrition in the Prevention and Treatment of Disease

Nutrition in the Prevention and Treatment of Disease
Author: Ann M. Coulston,Carol J. Boushey,Mario Ferruzzi
Publsiher: Academic Press
Total Pages: 921
Release: 2013
Genre: Medical
ISBN: 9780123918840

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Expertly edited, the Second Edition of Nutrition in the Prevention and Treatment of Disease offers 18 completely new chapters and 50% overall material updated. Given its unique focus and extensive coverage of clinical applications and disease prevention, this edition is organized for easy integration into advanced upper-division or graduate nutrition curriculums. Foundation chapters on nutrition research methodology and application clearly link the contributions of basic science to applied nutrition research and, in turn, to research-based patient care guidelines. Readers will learn to integrate basic principles and concepts across disciplines and areas of research and practice as well as how to apply this knowledge in new creative ways. Chapters on specific nutrients and health cover topics where data are just beginning to be identified, such as choline, antioxidants, nutrition and cognition, and eye disease. Established areas of chronic disease: obesity, diabetes, cardiovascular disease, gastrointestinal disease, and bone health are presented each in their own sections, which aim to demonstrate the inter-action of basic science, genetics, applied nutrition research, and research-based patient care guidelines. No other nutrition book on the market takes this approach. Students will take away foundational insights into the application of nutrition research in the prevention and treatment of disease. Busy researchers and clinicians will use this book as a “referesher course? and should feel confident in making patient care recommendations based on solid current research findings. * 18 completely new chapters and 50% overall new material * Unique focus and extensive coverage of clinical applications and disease prevention. * Clearly links the contributions of basic science to applied nutrition research and, in turn, to research-based patient care guidelines. * Assimilates a large body of research and applications and serves as a “refresher course? for busy researchers and clinicians.

Cancer Therapy The Challenge of Handling a Double Edged Sword

Cancer Therapy  The Challenge of Handling a Double Edged Sword
Author: Raquel Abalo,Kulmira Nurgali,John A. Rudd,Halina Was
Publsiher: Frontiers Media SA
Total Pages: 345
Release: 2022-10-18
Genre: Science
ISBN: 9782889766444

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The impact of alkalizing the acidic tumor microenvironment to improve efficacy of cancer treatment

The impact of alkalizing the acidic tumor microenvironment to improve efficacy of cancer treatment
Author: Hiromi Wada,Reo Hamaguchi,Shinji Uemoto
Publsiher: Frontiers Media SA
Total Pages: 164
Release: 2023-07-21
Genre: Medical
ISBN: 9782832526934

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