Engineering Physiology

This book provides an introduction to qualitative and quantitative aspects of human physiology. It examines biological and physiological processes and phenomena, including a selection of mathematical models, showing how physiological problems can be mathematically formulated and studied. It also illustrates how a wide range of engineering and physics topics, such as electronics, fluid dynamics, solid mechanics and control theory can be used to describe and understand physiological processes and systems. Throughout the text, there are introductions to measuring and quantifying physiological processes using both signaling and imaging technologies. This new edition includes updated material on pathophysiology, metabolism and the TCA cycle, as well as more advanced worked examples. This book describes the basic structure and models of cellular systems, the structure and function of the cardiovascular system, and the electrical and mechanical activity of the heart, and provides an overview of the structure and function of the respiratory and nervous systems. It also includes an introduction to the basic concepts and applications of reaction kinetics, pharmacokinetic modelling and tracer kinetics. It appeals to final year biomedical engineering undergraduates and graduates alike, as well as to practising engineers new to the fields of bioengineering or medical physics.

This fifth edition of “Engineering Physiology” has the same purpose as the earlier prints: to provide physiological information which engineers, designers, supervisors, managers and other planners need to make work and equipment “fit the human.” Chapters have been revised, figures and tables updated. New material discusses, among other topics, models of the human body that provide practical and design-oriented information, biomechanics describing the body’s capabilities and limitations, effects of shift work / sleep loss on attitude and performance, and new techniques to measure body sizes and the resultant changes in applications of that information. The book does not replace standard (biological-medical-chemical) textbooks on human physiology; instead, it provides information on human features and functions which are basic to ergonomics or human (factors) engineering, terms often used interchangeably. It helps lay the foundations for teamwork among engineers and physiologists, biologists and physicians. Bioengineering topics concern bones and tissues, neural networks, biochemical processes, bio- and anthromechanics, biosensors, perception of information and related actions, to mention just a few areas of common interest. Such understanding provides the underpinnings for devising work tasks, tools, workplaces, vehicles, work-rest schedules, human-machine systems, homes and designed environments so that we humans can work and live safely, efficiently and comfortably.

Physiology, Biophysics and Biomedical Engineering provides a multidisciplinary understanding of biological phenomena and the instrumentation for monitoring these phenomena. It covers the physical phenomena of electricity, pressure, and flow along with the adaptation of the physics of the phenomena to the special conditions and constraints of biological systems. While the text focuses on human biological systems, some of the principles also apply to plants, bacteria, and other animals. The first section of the book presents a general introduction to physiological systems and describes specialized methods used to record electrical events from biological tissue. The next part examines molecules involved in cell transport and signaling as well as the proteins relevant in cells’ ability to contract and generate tension. The text goes on to cover the properties of the heart, blood, and circulation and the monitoring of cardiac and circulatory function. It then discusses the importance of the interrelationship of pressures and flows in organ systems, such as the lungs and kidneys, and details the organization and function of the nervous system. After focusing on the systems used to monitor signals, the book explores modeling, biomechanics, and emerging technologies, including the progressive miniaturization of sensors and actuators in biomedical engineering. Developed from the authors’ courses in medical biophysics and biomedical instrumentation, this book shows how biophysics and biomedical engineering have advanced modern medicine. It brings together the physical principles underlying human physiological processes and the physical methods used to monitor these processes. Requiring only basic mathematical knowledge, the text supplements mathematical formulae with qualitative explanations and illustrations to encourage an intuitive grasp on the processes discussed.

Engineering Physiology Bases of Human Factors/Ergonomics How tall are people nowadays? How far can we reach? How high do we sit? How strongly do we push with a hand or foot? How does the body develop strength? What are our work capabilities? How can we measure and judge them? How can we, at the same time, make work easy and effective? Engineering Physiology, Third Edition, describes the bases of human factors and ergonomics by providing answers to these and many other questions concerning the size, build, and functioning of the human body at work. This information is presented in clear, concise language, not in the jargon of physiology, biology, or medicine; it does not require background knowledge from the reader, just interest--and it is interesting to read. This practical guide shows how the body monitors itself, how it reacts to workloads and environmental stresses such as heat or cold, humidity, and wind. Each chapter focuses on real-world applications of specific physiological knowledge in the workplace to help assure high performance with minimal effort. A wealth of information on anthropometry is also included, exploring the size and mobility of the human body and the various ways of designing for different sizes--there is no "average" person. There is a thorough discussion of the architecture, functioning, and biomechanics of bones, joints, muscles, tendons, and ligaments. It becomes clear how they develop forces and torques and move the body at work or sports. Overhead work, or sitting and standing still for a long time, is fatiguing: the team of authors explains why. Our bodies prefer dynamic activities to sustained static effort: we want to move about. The book explains energy extraction from food and drink, what efforts the body is capable of, and how this depends on the cooperation of respiratory, circulatory, and metabolic systems. It points out ways of measuring and assessing a person's ability to work and continue working, such as the observation of a subject's breathing rate, heart beat rate, and oxygen consumption. The effects of environmental conditions (heat, cold, humidity, air movement) and of shift work (day, evening, and night work) on task performance are discussed in practical terms. There are advantages, and some drawbacks, to "compressed work weeks" and "flextime"! The Third Edition of Engineering Physiology has new information on body size and how to fit equipment to it. The book describes how we develop muscle strength and transmit it along the limbs to a handle or pedal--and how to design for that application of force or torque. It explains what happens in repetitive trauma and how to avoid "carpal tunnel syndrome." What can we expect from "reengineering" the body; how can artificial joints replace worn out hips and knees? The third edition of this successful book provides numerous ideas to human factors engineers, designers, managers, industrial hygienists, safety personnel, plant engineers and supervisors, students, and anyone else interested in the ergonomics of "fitting work to the human body."

This book discusses the architecture, functioning, and biomechanics of the human body, its bones, joints, muscles, tendons, and ligaments. The book explains energy extraction from food and drink, what efforts the body is capable of, and how our efforts depend on the coordination among the respiratory, circulatory, and metabolic systems. This text shows how the body monitors itself, how it reacts to work loads and the environment such as heat or cold, humidity and wind. The book also explains how to measure a person’s ability to work at high efficiency: by observation of breathing rate, heart beat frequency, oxygen consumption, and by careful evaluation of subjective judgements.The text discusses, in practical terms, effects of environmental conditions and how shift work arrangements during day, evening, and night affect task performance.

This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises

Quantitative Human Physiology: An Introduction is the first text to meet the needs of the undergraduate bioengineering student who is being exposed to physiology for the first time, but requires a more analytical/quantitative approach. This book explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations, it provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects. Features a quantitative approach that includes physical and chemical principles Provides a more integrated approach from first principles, integrating anatomy, molecular biology, biochemistry and physiology Includes clinical applications relevant to the biomedical engineering student (TENS, cochlear implants, blood substitutes, etc.) Integrates labs and problem sets to provide opportunities for practice and assessment throughout the course NEW FOR THE SECOND EDITION Expansion of many sections to include relevant information Addition of many new figures and re-drawing of other figures to update our understanding and clarify difficult areas Substantial updating of the text to reflect newer research results Addition of several new appendices including statistics, nomenclature of transport carriers, and structural biology of important items such as the neuromuscular junction and calcium release unit Addition of new problems within the problem sets Addition of commentary to power point presentations

Engineering Principles in Physiology, Volume I covers the various aspects of biomedical engineering. This volume is organized into three parts encompassing 12 chapters that consider a holistic approach to physiology and the principles of communication and control, including energy input and output. The first part deals with the physiological information and related concepts, as well as the overall integration in the living body. The second part highlights the communication integration of the central nervous system as a whole with the body's various sense organs. The third part focuses on the diversity of function and modeling of various glandular functions of the endocrine system. This part briefly deals with the cardiovascular system as a system of communication and control. This book will prove useful to physiologists, biomedical engineers, and workers in the related fields.