Epigenetics in Precision Medicine

Epigenetics in Precision Medicine
Author: Jose Luis Garcia-Gimenez
Publsiher: Elsevier
Total Pages: 616
Release: 2021-11-12
Genre: Medical
ISBN: 9780323858052

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In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice Features chapter contributions from international leaders in the field

Epigenetic Biomarker and Personalized Precision Medicine

Epigenetic Biomarker and Personalized Precision Medicine
Author: Jiucun Wang,Dongyi He,Momiao Xiong,Yun Liu
Publsiher: Frontiers Media SA
Total Pages: 485
Release: 2020-12-21
Genre: Science
ISBN: 9782889661848

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Cancer Epigenetics for Precision Medicine

Cancer Epigenetics for Precision Medicine
Author: Ramona G. Dumitrescu,Mukesh Verma
Publsiher: Humana Press
Total Pages: 298
Release: 2018-10-12
Genre: Medical
ISBN: 149398750X

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This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based precision medicine in lung cancer; interplay between genetic and epigenetic changes in breast cancer subtypes; genetic regulation of PDCD1 gene in cancer immunology; and pyrosequencing methylation analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Cancer Epigenetics for Precision Medicine: Methods and Protocols is a valuable resource to help researchers and scientists identify these specific biomarkers and work towards the prevention, diagnosis, and prognosis of different cancers in the future.

Medical Epigenetics

Medical Epigenetics
Author: Anonim
Publsiher: Academic Press
Total Pages: 972
Release: 2021-08-27
Genre: Medical
ISBN: 9780128243268

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Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Organized from system disorders to multi-system disorders that involve epigenetic aberrations Examines the role of epigenetics in precision medicine

Integrative Preventive Medicine

Integrative Preventive Medicine
Author: Richard H. Carmona,Mark Liponis
Publsiher: Oxford University Press
Total Pages: 585
Release: 2017-12-12
Genre: Medical
ISBN: 9780190241254

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For most clinicians, the science and evidence for many integrative therapies is largely unknown or considered suspect. Most physicians don't have time to learn integrative approaches and aren't sure what to recommend or which approaches have merit or improved outcomes. Here, clinicians have easy access to the best practices in integrative medicine and expectations for outcomes

Epigenetics and Precision Medicine

Epigenetics and Precision Medicine
Author: Jingde Zhu
Publsiher: Naturalogic Publishing Incorporated
Total Pages: 480
Release: 2022-09-15
Genre: Medical
ISBN: 1487808569

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This book brings together dozens of top experts in the field of epigenetics in China and abroad, including two academics of the Chinese Academy of Sciences, seven winners of The National Science Fund for Distinguished Young Scholars, numerous outstanding young researchers, and experts in the Thousand Talents Plan, among others. It comprehensively and systematically expands on the latest research findings in epigenetics and precision medicine. The authors of this book combined their research findings and experience to explain concepts, mechanisms, and new technologies in epigenetic regulation and their immense prospects in the precise diagnosis and treatment of major diseases. The book also covers the fundamentals and translational research like DNA methylation, histone modification, higher-order chromatin structure, non-coding RNA, RNA modification, stem cell biology, and the epigenetics of traditional Chinese medicine. This book can serve as an important reference text for scientists and clinicians involved in basic and clinical research in epigenetics and those who are working to overcome major diseases.

Personalized Precision Medicine Role of Epigenetic Biomarkers

Personalized Precision Medicine  Role of Epigenetic Biomarkers
Author: Tommy Royal
Publsiher: American Medical Publishers
Total Pages: 0
Release: 2023-09-19
Genre: Medical
ISBN: 9798887403717

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Epigenetics is the study of heritable phenotype changes that do not entail changes in the DNA sequence. Epigenetic abnormalities have emerged as the most promising biomarkers for diagnosis and prognosis in the early stage of illnesses, such as cancer, autoimmune diseases and psychological disorders. A medical model in which people are divided into groups with medical decisions, practices, interventions and products being tailored to the individual patient based on their predicted response or risk of disease is referred as personalized medicine. The terms precision medicine and personalized medicine are utilized interchangeably for describing the concept. Diagnostic testing is used often in personalized medicine to determine suitable and optimal therapies based on a patient's genetic content, or other molecular or cellular analysis. Certain aspects of personalized medicine utilize genetic information, such as pharmacogenomics. With the help of genomics, proteomics and imaging techniques, molecular scale data of the patients is obtained easily. These molecular biomarkers are then used in determining the prognosis of diseases such as cancer. The readers would gain knowledge that would broaden their perspective about personalized precision medicine through this book. Also included herein is a detailed explanation of the role of epigenetic biomarkers. This book will help the readers in keeping pace with the rapid changes in this field of study.

Clinical Precision Medicine

Clinical Precision Medicine
Author: Judy S. Crabtree
Publsiher: Academic Press
Total Pages: 114
Release: 2019-11-15
Genre: Medical
ISBN: 9780128204023

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Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource