Gout Other Crystal Arthropathies

Gout and Other Crystal Arthropathies, by Dr. Robert Terkeltaub, presents the state-of-the-art, clinically-focused coverage you need to manage these increasingly prevalent diseases. Diagnose the full range of crystal arthropathies-including pseudogout, intercritical gout, hyperuricemia, and gouty arthritis-and treat your patients effectively with discussions of recently-approved drugs like Uloric and those currently under review, such as Kristexxa and Colcryst. With coverage of the latest therapies, preventions, and imaging studies, along with access to the fully searchable text online at www.expertconsult.com, this comprehensive resource is ideal for any physician who diagnoses, treats, and manages gout and crystal-induced arthropathies. Access the fully searchable contents online at www.expertconsult.com. Stay current on recent developments such as uricosuric therapy and inhibitor therapy; gout flare prophylaxis and colchicines; ultrasound in the diagnosis of crystal deposition diseases; imaging of gout, CPPD, and hydroxyapatitie deposition diseases; and uricase therapy of gout. Manage the full range of crystal arthropathies with 25 clinically-focused chapters on pseudogout, intercritical gout, hyperuricemia, gouty arthritis, and more. Treat your patients effectively using the latest information on drug treatments, from the recently-approved Uloric to Kristexx and Colcryst, which are still under review. The tools to you need to diagnose, treat, and manage gout and other crystal arthropathies

Seminar paper from the year 2018 in the subject Medicine - Epidemiology, grade: 1, Egerton University, language: English, abstract: Gout and pseudogout are believed to the most prevalent crystal-induced arthropathies in humans. These disorders occur due to the deposition of crystals in the joints and soft tissues. This results into periarticular and articular inflammation and injury. Some of the most common crystals that are responsible for arthropathies such as gout and pseudogout include hydroxyapatite, monosodium urate (MSU), calcium oxalate and calcium pyrophosphate dehydrate (CPPD) (Rothschild, 2014). In practice, gout and pseudogout are relatively different despite the fact that they are crystal-induced arthropathies, and their difference can be explained by their definitions. Gout is defined as a crystal deposition disease that is characterized by the precipitation and super-saturation of monosodium urate (MSU) in tissues. This deposition of monosodium urate crystals causes inflammation of the joints and soft tissues, and this is attributable to tissue damage. Therefore, gout is characterized by sub-acute or acute attacks of joints or the inflammation of soft tissues resulting from the deposition of monosodium urate. The clinical course of gout involves an underlying metabolic aberrancy referred to as hyperuricemia which is defined as the serum urate level of more than 6.8 mg/dL (Al-Ashkar, 2010). On the other hand, pseudogout is defined as a clinical syndrome that resembles gout, and it is caused by the deposition of calcium pyrophosphate dehydrate crystals in soft tissues and joints, resulting into the inflammation and cartilage tissue damage. Therefore, the term pseudogout emanates from the nature of its clinical presentation in which acute attacks of the joints resembles those observed in gout (Al-Ashkar, 2010). However, it is worth noting that, in pseudogout, chondrocalcinosis is the most distinctive feature for the syndrome although some patients with chondrocalcinosis do not present with pseudogout. This seminar paper focuses on gout and pseudogout.

This excellent reference discusses the clinical manifestations and differential diagnosis of gout, hyperuricemia, and related arthropathies resulting from crystals deposited in joints. Presents new findings in inflammation pathogenesis! Providing historical perspective as well as the most up-to-date science, Gout, Hyperuricemia, and Other Crystal-Associated Arthropathies describes the mechanisms of inflammation profiles the cellular and molecular biology of crystal-cell interaction reviews groundbreaking epidemiological studies of gout outlines acute neutrophil-mediated synovitis details the uses of radiographic imaging in detecting and analyzing crystal deposition highlights musculoskeletal syndromes associated with calcium oxalate, calcium pyrophosphate, and other types of crystals links gout to conditions such as diabetes, obesity, hypertension, and alcohol consumption extends insights from gout research to other types of arthritis and more! Featuring over 500 references, tables, drawings, photographs, and micrographs, Gout, Hyperuricemia, and Other Crystal-Associated Arthropathies is suitable for rheumatologists, orthopedists and orthopedic surgeons, internists and primary care physicians, clinical pharmacologists, rehabilitation and inflammatory disease specialists, neurologists, immunologists, physiotherapists, occupational therapists, and medical school and graduate students in these disciplines.

Gout is now the most common form of inflammatory arthritis in the United States, with a recent resurgence of research interest in its cause and management. Calcium crystal-related arthritis has also attracted renewed attention, with new nomenclature having been recently elaborated, aiding contemporary research efforts. This topic has never been covered in Rheumatic Disease Clinics and it represents a large content hole. The articles will cover diagnosis, management, emerging therapies and imaging.

A trustworthy clinical companion, the textbook offers best practice and management strategies for these common joint diseases. Formerly published as Osteoarthritis, the extensively revised third edition of the Oxford Textbook of Osteoarthritis and Crystal Arthropathy provides up-to-date and evidence-based guidance on how to assess, diagnose, and manage patients. A prestigious and international author team ensure information is expert and relevant-this is a practical tool for clinicians managing people with osteoarthritis, gout, and other crystal-associated arthritis. Confidently consider and chose the right blend of treatment for your patient, whether physical, pharmacological, surgical, or supportive. The Oxford Textbook of Osteoarthritis and Crystal Arthropathy provides full coverage of joint failure, and includes detailed sections on epidemiology, risk factors, clinical assessment, and investigations. This edition also now includes new sections on gout and other crystal arthropathies. Clinically relevant and easily understandable overviews of basic science, including pathology and pain physiology, along with critical appraisal of current guidelines, make this a highly valuable resource. Significant coverage is also given to patient education and the involvement of the patient in management planning. Also highly illustrated, the textbook is a strong reference tool with summary boxes and key points at the end of chapters making it easy to find information quickly and help you deliver the optimum patient outcome. The textbook equips rheumatologists and musculoskeletal health professionals with the knowledge to provide best possible patient care.

Diagnosis and Treatment in Internal Medicine equips trainee doctors with the essential skills and core knowledge to establish a diagnosis reliably and quickly, before outlining the management of the clinical condition diagnosed. Organised into three sections, the first provides a vital overview, whilst the second focuses on common presentations and diagnoses. Uniquely, this new book shows readers how to turn symptoms into a list of diagnoses ordered by probability - a differential diagnosis. Experienced consultants who teach trainees every day demonstrate how to derive an ordered differential diagnosis, how to narrow this down to a single diagnosis and if not, how to live with diagnostic uncertainty. The final section provides a comprehensive account of the management of system-based syndromes and diseases. Highly-structured chapters emphasize how common conditions present, how to approach a diagnosis, and how to estimate prognosis, treatment and its effectiveness. An onus is placed on the development of crucial diagnostic skills and the ability to devise evidence-based management plans quickly and accurately, making this an ideal text for core medical trainees.