Janeway S Immunobiology

This book presents case histories to illustrate in a clinical context essential points about the mechanisms of immunity. It includes cases that illustrate both recently discovered genetic immunodeficiencies and some more familiar and common diseases with interesting immunology.

Explore the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the bookÕs clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope and depth. This edition is thoroughly revised and up to date with significant developments in the field, especially on the topic of innate immunity.

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

This authoritative textbook summarises the basic immunological concepts, looks at the main aspects of adaptive immunity, then integrates all the preceding material at the level of the complete organism in both health and disease.

The definitive text--completely updated and revised

Janeway's Immunobiologyis a textbook that introduces the immune system in all its aspects to undergraduates, and also provides a treatment of the subject that is comprehensive enough to be useful to graduate students interested in research, and to medical students focused on clinical applications. The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats. Janeway's Immunobiologycontinues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout--that of the host's interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology. Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo. New in the Eighth Edition Innate immunityhas been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes). The section on complementhas been reworked and reconceived--explaining the lectin pathway first--making it easier to teach by placing it into the context of innate recognition. Evolutionis now incorporated throughout the text, helping students see similar strategies used by different organisms. The text and figures of Chapter 7 Signaling Through Immune System Receptorshave been revised to present a cohesive synthesis of signalingfor immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book. Updated chapter on B-cell immune responses(Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen. Coverage of mucosal immunity(Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways. Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines. Many new and revised figuresillustrate the processes and mechanisms underlying the concepts presented in the text. The iconsused have been updated and expanded to incorporate a new emphasis on signaling pathways. New referenceshave been added throughout the text.

This text emphasizes the human immune system and presents concepts with a balanced level of detail to describe how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. This classroom-proven textbook offers clear writing, full-color illustrations, and section and chapter summaries that make the content accessible and easily understandable to students.

This case study is about a 29-year-old professional oboe player who was first diagnosed for optic neuritis and then for multiple sclerosis (MS). MS is an example of a T-cell mediated autoimmune disease, wherein there is an autoimmune attack on the integrity of the central nervous system.