Mechanisms Of Morphogenesis

Morphogenesis is the set of processes that generate shape and form in the embryo--an important area within developmental biology. An exciting and up-to-the-minute account of the very latest research into the factors that create biological form, Mechanisms of Morphogenesis, second edition is a text reference on the mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. By combining hard data with computer modeling, Mechanisms of Morphogenesis, second edition equips readers with a much broader understanding of the scope of modern research than is otherwise available. The book focuses on the ways in which the genetic program is translated to generate cell shape, to direct cell migration, and to produce the shape, form and rates of growth of the various tissues. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and pointers to future Includes over 200 four-color figures Offers an integrated view of theoretical developmental biology and computer modelling with laboratory-based discoveries Covers experimental techniques as a guide to the reader Organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems

This book, first published in 1990, provides an overview of the events and mechanisms of morphogenesis.

This volume examines how generative mechanisms emerge in the social order and their consequences. It does so in the light of finding answers to the general question posed in this book series: Will Late Modernity be replaced by a social formation that could be called Morphogenic Society? This volume clarifies what a ‘generative mechanism’ is, to achieve a better understanding of their social origins, and to delineate in what way such mechanisms exert effects within a current social formation, either stabilizing it or leading to changes potentially replacing it . The book explores questions about conjuncture, convergence and countervailing effects of morphogenetic mechanisms in order to assess their impact. Simultaneously, it looks at how products of positive feedback intertwine with the results of (morphostatic) negative feedback. This process also requires clarification, especially about the conditions under which morphostasis prevails over morphogenesis and vice versa. It raises the issue as to whether their co-existence can be other than short-lived. The volume addresses whether or not there also is a process of ‘morpho-necrosis’, i.e. the ultimate demise of certain morphostatic mechanisms, such that they cannot ‘recover’. The book concludes that not only are generative mechanisms required to explain associations between variables involved in the replacement of Late Modernity by Morphogenic Society, but they are also robust enough to account for cases and times when such variables show no significant correlations.

"A concise account of what we know about development discusses the first vital steps of growth and explores one of the liveliest areas of scientific research."--P. [2] of cover.

Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Aimed at postgraduate students in a variety of biology-related disciplines, this volume presents a collection of mathematical and computational single-cell-based models and their application. The main sections cover four general model groupings: hybrid cellular automata, cellular potts, lattice-free cells, and viscoelastic cells. Each section is introduced by a discussion of the applicability of the particular modelling approach and its advantages and disadvantages, which will make the book suitable for students starting research in mathematical biology as well as scientists modelling multicellular processes.