Mechanobiology of Fracture Healing

Mechanobiology of Fracture Healing
Author: Lutz E. Claes
Publsiher: Springer Nature
Total Pages: 104
Release: 2022-04-24
Genre: Technology & Engineering
ISBN: 9783030940829

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This book offers a summary of research on the biomechanics of fracture fixation and mechanobiology of fracture healing. The author, a known expert, provides an overview of the state of art, his own research together with that of his co-workers and collaborators; he describes the ideas and findings from the beginning of this research field in the 1960s up to the clinical consequences and applications of today. The book discusses the mechanobiology of fracture healing, illustrates the numerical methods that simulate fracture healing processes, and depicts specific research methods of experimental studies. Finally, it provides conclusions for the improvement of fracture treatment that will be of use in clinical applications nowadays. This book will be a valuable resource of knowledge for students and scientists in the field of bioengineering, experimental biology, and biomechanics, helping them to identify the correct conditions and analysis for their respective research and receive an understanding of the research field from its beginning until today. For experimental and clinical surgeons active in the field of fracture healing, this book will provide a useful historical overview over this translational research field.

Multiscale Mechanobiology of Bone Remodeling and Adaptation

Multiscale Mechanobiology of Bone Remodeling and Adaptation
Author: Peter Pivonka
Publsiher: Springer
Total Pages: 287
Release: 2017-06-20
Genre: Science
ISBN: 9783319588452

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The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease
Author: Stefaan Verbruggen
Publsiher: Academic Press
Total Pages: 527
Release: 2018-08-09
Genre: Technology & Engineering
ISBN: 9780128129531

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Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

The Mechanobiology of Diaphyseal Secondary Bone Healing

The Mechanobiology of Diaphyseal Secondary Bone Healing
Author: Devakara Rao Epari
Publsiher: Unknown
Total Pages: 119
Release: 2006
Genre: Electronic Book
ISBN: 3832254781

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Elements of Fracture Fixation E book

Elements of Fracture Fixation   E book
Author: Anand J. Thakur
Publsiher: Elsevier Health Sciences
Total Pages: 420
Release: 2015-07-30
Genre: Medical
ISBN: 9788131242377

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Timely, accurate, and up-to-date text clearly explaining the fundamentals of fracture healing and bone fixation in a format that is concise, well organized and easy to follow. It is extremely well illustrated and addresses the biomechanical principles and usage techniques of the wide range of modern orthopaedic trauma implants in use today. • An in-depth resource to the amply stocked tool-box of today’s fracture surgeon • A compendium of fracture fixation written by an experienced surgeon for fellows, residents and masters • A detailed overview of biomechanics, biology, implants and materials relevant to fracture care • Elegantly illustrated and lucidly explained presentations of today’s fracture fixation devices • The designs, the application techniques in various anatomical regions, mechanical effects, hazards and contraindications are described along elucidative graphics • Not so commonly found details of intramedullary nail and use of Poller screws in its insertion, hazards of use of traction table, methods to perfect insertion of intramedullary hip fixation device, minute details of cables, pins and wires, several configurations of external fixator, new concept of reverse dynamization, a brief exposure of spinal instrumentation and several techniques of minimal invasive osteosynthesis are a few of its features

Musculoskeletal Disorders and the Workplace

Musculoskeletal Disorders and the Workplace
Author: Institute of Medicine,National Research Council,Commission on Behavioral and Social Sciences and Education,Panel on Musculoskeletal Disorders and the Workplace
Publsiher: National Academies Press
Total Pages: 511
Release: 2001-06-24
Genre: Business & Economics
ISBN: 9780309072847

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Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials.

The Pathomechanics Of Tissue Injury And Disease And The Mechanophysiology Of Healing

The Pathomechanics Of Tissue Injury And Disease  And The Mechanophysiology Of Healing
Author: Amit Gefen
Publsiher: Unknown
Total Pages: 414
Release: 2009-01-01
Genre: Bones
ISBN: 8130803143

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Over the last decade, it became clear that mechanical factors, such as deformations, forces and stiffness properties have critical influence on a wide spectrum of diseases. Traditionally, since the 1960's, mechanics has been associated mainly with orthopaedics, trauma and rehabilitation as well as with cardiovascular problems, and so, the work of biomechanists was mostly related to these areas. This led, for example, to good understanding of the loading conditions at which bone fractures occur, and how bone fractures can be healed more quickly if their mechanical environment is adequately controlled (e.g. via compression plate-screw systems). However, more recently, on the 1980's-1990's, it was discovered that mechanics has much more fundamental roles and effects on biological processes, as many cell types appeared to be responsive to mechanical stimuli. This boosted biomechanical research on the effects of mechanical factors at the microscopic scale of tissues, and the fields of mechanobiology and mechanotransduction emerged. Most recently, on the 2000's, there were studies, e.g. by Dr. Valerie Weaver and colleagues (as described in this book), reporting that at the cell scale, inadequate mechanical stimuli may even provoke cancer. Hence, the role of integration between mechanics, life sciences and medicine is growing rapidly, and becomes more important by the day. What allows this integration to expand so fast is the development of sophisticated bioengineering research and analysis tools. These include highly realistic computer simulations, small animal MRI, micro-sensors, bio-reactors and many other recent breakthroughs that allow precision measurements of the mechanical conditions that apply in tissues at different levels of architectural hierarchy, whereas at the same time, close monitoring of the biological responses to these mechanical conditions became possible. This exciting atmosphere is at the background of the present book, which contains perspectives from leading scientists worldwide on the role of mechanics in injury, disease and healing. The topics covered span from bone tumors to pressure ulcers and from osteoarthritis to breast cancer, which illustrates how mechanics is now identified as the common denominator in so many important chronic conditions, as opposed to just trauma. In view of the multi-disciplinary and diverse nature of this book, I expect it to be appealing to a broad readership, obviously including biomechanists but also medical doctors, physiologists, cell biologists, physiotherapists, nurses and all those who are interested in reading on the latest developments in our journey towards understanding the complex connections between mechanics and biology.

Basic Orthopaedic Biomechanics and Mechano Biology

Basic Orthopaedic Biomechanics and Mechano Biology
Author: Van C. Mow,Rik Huiskes
Publsiher: Lww
Total Pages: 736
Release: 2015-04-24
Genre: Electronic Book
ISBN: 1469878100

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Completely revised and updated, the Third Edition of this classic text reflects the latest advances in research on orthopaedic biomechanics and the successful applications of biomechanical principles in fracture fixation, prosthetic implant design, and hip and knee arthroplasty. For this Third Edition, Dr. Mow is joined by new co-editor Rik Huiskes, PhD, an Editor-in-Chief of the Journal of Biomechanics and an internationally renowned authority in the field. New chapters cover biomaterials, biomechanical principles of cartilage and bone tissue engineering, and biomechanics of fracture fixation and fracture healing.