Microbiology For Surgical Infections

Microbiology for Surgical Infections: Diagnosis, Prognosis and Treatment explores current trends in etiology and antibiotic resistance of pathogens responsible for devastating and complex surgical infections. Clinicians and researchers report the most recent advances in diagnostic approaches to bacterial and non-bacterial surgical infections, including invasive fungal infections. Current guidelines for prophylaxis of community-acquired and nosocomial infections, complications in surgery, and improvement of diagnosis and treatment of these devastating surgical infections are also discussed. The work gives specific attention to intra-abdominal and wound infections, as well as infections in cardiac surgery and neurosurgery. Taken together, these explorations inform the work of specialists in different surgical arenas, as well as those working in microbiology. Microbiology for Surgical Infections provides a resource to those working to improve outcomes in this complicated arena by discussing prospects for future study and identifying targets for future research. Provides a multi-dimensional view of myriad topics pertinent to surgical infections, including questions of etiology, pathogenesis, host-microbial interactions, diagnosis, prognosis, treatment and prophylaxis Delivers cutting-edge commentary from eminent surgeons, microbiologists, and infectious disease specialists, with global contributions from both the developed and developing worlds Presents comprehensive research informed by the most recent technological and scientific advances in the field

Although most clinicians are aware of the problem of antimicrobial resistance, most also underestimate its significance in their own hospital. The incorrect and inappropriate use of antibiotics and other antimicrobials, as well as poor prevention and poor control of infections, are contributing to the development of such resistance. Appropriate use of antibiotics and compliance with infection prevention and control measures should be integral aspects of good clinical practice and standards of care. However, these activities are often inadequate among clinicians, and there is a considerable gap between the best evidence and actual clinical practice. In hospitals, cultural determinants influence clinical practice, and improving behaviour in terms of infection prevention and antibiotics-prescribing practice remains a challenge. Despite evidence supporting the effectiveness of best practices, many clinicians fail to implement them, and evidence-based processes and practices that are known to optimize both the prevention and the treatment of infections tend to be underused. Addressing precisely this problem, this volume offers an essential toolkit for all surgeons and intensivists interested in improving their clinical practices.

The Microbiology of Skin, Soft Tissue, Bone and Joint Infections: Volume 2 discusses modern approaches in diagnosis, treatment, and prophylaxis of skin, soft tissue, bone, and joint infections. The volume has been divided into three sections. The first section includes chapters on diagnosis, treatment, and prophylaxis of skin and soft tissue infections. It discusses antimicrobial and surgical treatment of wounds, diabetic foot, and different soft tissue infections. Ten chapters are devoted to cutaneous and musculoskeletal infections in special groups of patients, which have their own specificity, i.e. in pediatric and HIV-infected patients. Together with chapters on commonly present diseases, there are chapters which discuss interesting but not well studied pathologies (natal cleft pilonidal sinus) and pathogens (Malassezia and Shewanella spp.). The second section reviews etiology, pathogenesis, diagnosis and treatment of bone and joint infections, mainly osteomyelitis and prosthetic joint infections. Also, one chapter in this section discusses a newly emerging bacterial pathogen that causes skeletal infections, Kingella kingae. The third section incorporates alternative and new approaches—such as nanotechnology, ultrasound, novel delivery approaches and phyto-derived medicines—to the treatment and prophylaxis of skin, soft tissue, bone, and joint infections. Encompasses a broad range of skin, soft tissue, bone, and joint infections, including questions of etiology, pathogenesis, diagnosis, prognosis, treatment, and prophylaxis Written by highly professional and eminent surgeons, microbiologists, and infectious disease specialists Discusses topics using modern insight, providing all necessary scientific information on each aspect Includes scientific understanding and practical guidelines, which make it interesting for both research scientists and practitioners working with skin, soft tissue, bone, and joint infections

Skin is a natural barrier to infection. Surgical breakage of skin can lead to surgical site infections (SSIs). SSIs are relatively common and constitute a problematic issue in surgical procedures. Most common organisms include Gram-positive, such as Staphylococcus and Streptococcus, as well as Gram-negative, such as Pseudomonas and others, bacteria. The extent and outcome of SSI can vary widely depending on the procedure, organism, extent, and other factors, and can result in discomfort, severe morbidity, or even life-threatening conditions.It is thus mandatory to be aware of and follow WHO and CDC guidelines for the prevention of SSIs and to reduce risk factors for acquisition. This book sheds light on certain aspects related to SSIs and how to avoid them.

It is not the presence of microorganisms, but their interaction with patients that determines their influence on wound healing. Documenting this critical but often ignored aspect of the treatment process, Microbiology of Wounds discusses the microbiology and biology of human wounds in relation to infection and non-healing. Gain the Necessary Scientific and Clinical Knowledge Pertaining to Chronic and Acute Wounds The practice of wound healing is dynamic, infinitely complex, nonlinear, and prodigiously individualized to the patient. When one considers the myriad host variables that contribute to the disease state, understanding the intricacies of chronic wounds becomes even more difficult. This book presents the necessary scientific and clinical data pertaining to chronic and acute wounds, and discusses inflammation, epithelialization, granulation tissue, and tissue remodeling. It details techniques for treating chronic and acute wounds and covers the mode of action and efficacy of anti-infectives used in treating wounds. Microbiology of Wounds answers the call for a definitive reference on chronic and acute wounds.

Infections of the bones (osteomyelitis) and joints (septic arthritis) are serious health problems which require antibiotics and often surgery. Awareness among health professionals of the causes and treatment options for various types of bone and joint infections is essential for effective resolution. Bone and Joint Infections takes a multidisciplinary approach in covering the diagnostic and therapeutic treatment of osteomyelitis and septic arthritis, including different types of implant-associated infections. Correct and rapid diagnosis of bone and joint infection is crucial, and requires the input of a variety of specialists. Bone and Joint Infection takes a similarly collaborative and comprehensive approach, including chapters authored by clinicians, laboratory specialists, and surgeons. Covering the basic microbiology and clinical aspects of bone and joint infection, this book will be a valuable resource both for researchers in the lab and for physicians and surgeons seeking a comprehensive reference on osteomyelitis and septic arthritis.

Infection is the most common form of morbidity after all operative procedures and is one of the more common causes of postoperative death. The incidence of postoperative infection is incorporated into all surgical audit systems. Papers reporting developments in the basic science of infection, management of community acquired infection and trials to assess regimens of antibiotic prophylaxis to prevent infection are published in a wide range of medical journals, many beyond the range of reading of most surgeons. There have been rapid advances in the pharmaceutical industry which have led to the availability of many new antimicrobials and, for many surgeons, this has been a bewildering change. The microbiology and surgical management of infection have been reviewed in this book together with the current use of antibiotics for prophylaxis and therapy.

Approximately 60% of all hospital-associated infections, over one million cases per year, are due to biofilms that have formed on indwelling medical devices. Device-related biofilm infections increase hospital stays and add over one billion dollars/year to U.S. hospitalization costs. Since the use and the types of indwelling medical devices commonly used in modern healthcare are continuously expanding, especially with an aging population, the incidence of biofilm infections will also continue to rise. The central problem with microbial biofilm infections of foreign bodies is their propensity to resist clearance by the host immune system and all antimicrobial agents tested to date. In fact, compared to their free floating, planktonic counterparts, microbes within a biofilm are 50 – 500 times more resistant to antimicrobial agents. Therefore, achieving therapeutic and non-lethal dosing regimens within the human host is impossible. The end result is a conversion from an acute infection to one that is persistent, chronic, and recurrent, most often requiring device removal in order to eliminate the infection. This text will describe the major types of device-related infections, and will explain the host, pathogen, and the unique properties of their interactions in order to gain a better understanding of these recalcitrant infections.