PAF Platelets and Asthma

PAF  Platelets  and Asthma
Author: M. Schmitz-Schumann,Menz,Page
Publsiher: Birkhäuser
Total Pages: 260
Release: 2012-04-26
Genre: Science
ISBN: 3034874537

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Bronchial asthma is a disease with many unsolved problems and despite an increased availabili ty of anti-asthma drugs, morbidi ty and mortality from this disease are not improving. It is now recognized that asthma should be considered as a chronic inflammatory disease of the lung resulting in bronchial hyperreactivity and subsequent symptoms. The mechanisms underlying airways inflammation and bronchial hyperreactivity have now become a focal point of research in the quest for knowledge about how the management of this disease can be improved. Platelet activating factor (PAF-acether AGEPC) is a naturally occurring ether-linked phospholipid discovered in 1972 associated with IgE mediated allergic responses which has potent effects on platelet activation. PAF is now recognized as a molecule having a diverse range of biological effects relevant to allergic inflammation and asthma including the abili ty to induce long lasting airway inflammation and associated increases in bronchial reactivity. Certain activities of PAF are known to be secondary to platelets activation raising the possibility that this blood element plays a role in the pathogenesis of asthma.

PAF Platelets and Asthma

PAF  Platelets  and Asthma
Author: M. Schmitz-Schumann,Menz,Page
Publsiher: Birkhäuser
Total Pages: 0
Release: 2014-01-14
Genre: Science
ISBN: 3034874510

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Bronchial asthma is a disease with many unsolved problems and despite an increased availabili ty of anti-asthma drugs, morbidi ty and mortality from this disease are not improving. It is now recognized that asthma should be considered as a chronic inflammatory disease of the lung resulting in bronchial hyperreactivity and subsequent symptoms. The mechanisms underlying airways inflammation and bronchial hyperreactivity have now become a focal point of research in the quest for knowledge about how the management of this disease can be improved. Platelet activating factor (PAF-acether AGEPC) is a naturally occurring ether-linked phospholipid discovered in 1972 associated with IgE mediated allergic responses which has potent effects on platelet activation. PAF is now recognized as a molecule having a diverse range of biological effects relevant to allergic inflammation and asthma including the abili ty to induce long lasting airway inflammation and associated increases in bronchial reactivity. Certain activities of PAF are known to be secondary to platelets activation raising the possibility that this blood element plays a role in the pathogenesis of asthma.

PAF Platelets and Asthma

PAF  Platelets  and Asthma
Author: M. Schmitz-Schumann,G. Menz,C. P. Page
Publsiher: Birkhauser
Total Pages: 274
Release: 1987
Genre: Asthma
ISBN: UOM:39015012534080

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Platelet Activating Factor Acetylhydrolases PAF AH

Platelet Activating Factor Acetylhydrolases  PAF AH
Author: Anonim
Publsiher: Academic Press
Total Pages: 222
Release: 2015-12-01
Genre: Science
ISBN: 9780128039465

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This volume of The Enzymes summarizes the most important discoveries associated with a group of enzymes that play an important role in normal biological processes as presented and discussed by leaders authorities in the field. Contributions from leading authorities Informs and updates on all the latest developments in the field of enzymes

Inflammatory Cells and Mediators in Bronchial Asthma

Inflammatory Cells and Mediators in Bronchial Asthma
Author: Devendra K. Agrawal,Robert G. Townley
Publsiher: CRC Press
Total Pages: 272
Release: 2020-10-28
Genre: Medical
ISBN: 9781000142068

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Inflammatory Cells and Mediators in Bronchial Asthma provides reviews and summaries regarding state-of-the-art articles that examine the role of various inflammatory cells and their mediators in the pathogenesis of asthma. Topics include pharmacological and biochemical regulation of the airways; involvement of key inflammatory cells and the release and effect of their mediators in airway function; and the characteristics of receptors for leukotriene B4, C4, and D4, adenosine, platelet-activating factor, sensory and inflammatory peptides, and the effect of various anti-asthmatic drugs on airway inflammation. Physicians, allergists, immunologists, and pulmonary disease research scientists will find this book to be an invaluable reference resource.

Platelets in Thrombotic and Non Thrombotic Disorders

Platelets in Thrombotic and Non Thrombotic Disorders
Author: Paolo Gresele
Publsiher: Cambridge University Press
Total Pages: 1144
Release: 2002-05-30
Genre: Medical
ISBN: 052180261X

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Platelets have become an important research target for clinicians and basic scientists in a range of medical disciplines. This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. It will be an essential reference for biomedical scientists and clinicians in hematology, vascular medicine, cardiology, thrombosis and related disciplines.

Lipid Mediators

Lipid Mediators
Author: Fiona M. Cunningham
Publsiher: Elsevier
Total Pages: 392
Release: 2016-10-27
Genre: Health & Fitness
ISBN: 9781483217635

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The Handbook of Immunopharmacology: Lipid Mediators covers a comprehensive overview of lipid mediators, from synthesis through to inhibition. The book discusses the metabolism of arachidonic acid; the measurement of fatty acids and their metabolites; and the biological properties of cyclooxygenase products. The text also describes other essential fatty acids, their metabolites and cell-cell interactions; the inhibitors of fatty acid-derived mediators; as well as the biosynthesis and catabolism of platelet-activating factor. The cellular sources of platelet-activating factor and related lipids; the biological properties of platelet-activating factor; and the effects of platelet-activating factor receptor antagonists are also considered. Immunopharmacologists, immunologists, and pharmacologists will find the book invaluable.

The Non Thrombotic Role of Platelets in Health and Disease

The Non Thrombotic Role of Platelets in Health and Disease
Author: Steve W. Kerrigan,Niamh Moran
Publsiher: BoD – Books on Demand
Total Pages: 250
Release: 2015-11-18
Genre: Medical
ISBN: 9789535122081

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Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.