Patient Zero Revised Edition

Engrossing true stories of the pioneers of epidemiology who risked their lives to find the source of deadly diseases—now revised to include updated information and a new chapter on Covid-19. More people have died in disease epidemics than in wars or other disasters, but the process of identifying these diseases and determining how they spread is often a terrifying gamble. Epidemiologists have been ignored, mocked, or silenced all while trying to protect the population and identify “patient zero”—the first person to have contracted the disease, and a key piece in solving the epidemic puzzle. Patient Zero tracks the gripping tales of eight epidemics and pandemics—how they started, how they spread, and the fight to stop them. This revised edition combines a brand-new design with updated information and features diseases such as Spanish Influenza, Ebola, and AIDS, as well as a new chapter on Covid-19.

Engrossing true stories of the pioneers of epidemiology who risked their lives to find the source of deadly diseases. Throughout history, more people have died in disease epidemics than in wars or other disasters. The courageous, trail-blazing defenders against these diseases faced a terrifying personal gamble. Often they were ignored, laughed at, or even fired from their jobs. But they kept hunting for answers, putting the pieces of the epidemic puzzle together. As they looked for clues to the origin of a disease, scientists searched for the unknown “patient zero”—the first person to have contracted it. In nineteenth-century London, Dr. John Snow’s mapping of an epidemic found that patient zero was a six-month-old baby, whose cholera-laden diarrhea had contaminated the water of a local pump. It led to the death of 10,000 inhabitants exposed to the dirty water. Patient Zero brilliantly brings to life the main characters and events to tell the gripping tale of how each of seven diseases spread. • The Great Plague, 1665 • The Soho Outbreak,1854 • Yellow Fever in Cuba, 1900 • Typhoid in New York City, 1906 • Spanish Influenza, 1918-1919 • Ebola in Zaire, 1976 • AIDS in the U.S., 1980. The result is spine-chilling as Peters follows the scientists who solved the intricate mystery of the killer epidemics. Patient Zero reminds us that millions of people owe their lives to the work of these pioneer epidemiologists, work that continues to this day. Reviews: “The book reads like a thriller, with gripping accounts of how these diseases affected people.” —School Library Journal, 08/14 “ ... the mysterious nature of unexplained epidemics is perfectly captured ...” —Kirkus Reviews,08/20/14

An updated edition of Jacques Pépin's acclaimed account of the events that transformed a chimpanzee virus into a global pandemic.

Now an award-winning documentary feature film The search for a “patient zero”—popularly understood to be the first person infected in an epidemic—has been key to media coverage of major infectious disease outbreaks for more than three decades. Yet the term itself did not exist before the emergence of the HIV/AIDS epidemic in the 1980s. How did this idea so swiftly come to exert such a strong grip on the scientific, media, and popular consciousness? In Patient Zero, Richard A. McKay interprets a wealth of archival sources and interviews to demonstrate how this seemingly new concept drew upon centuries-old ideas—and fears—about contagion and social disorder. McKay presents a carefully documented and sensitively written account of the life of Gaétan Dugas, a gay man whose skin cancer diagnosis in 1980 took on very different meanings as the HIV/AIDS epidemic developed—and who received widespread posthumous infamy when he was incorrectly identified as patient zero of the North American outbreak. McKay shows how investigators from the US Centers for Disease Control inadvertently created the term amid their early research into the emerging health crisis; how an ambitious journalist dramatically amplified the idea in his determination to reframe national debates about AIDS; and how many individuals grappled with the notion of patient zero—adopting, challenging and redirecting its powerful meanings—as they tried to make sense of and respond to the first fifteen years of an unfolding epidemic. With important insights for our interconnected age, Patient Zero untangles the complex process by which individuals and groups create meaning and allocate blame when faced with new disease threats. What McKay gives us here is myth-smashing revisionist history at its best.

Millions of tons of plastic slip into oceans every year. Some floats and travels slowly with the currents, endangering the health of marine animals. The rest is hardly visible but is far more dangerous. Tiny bits of plastic sprinkle the ocean's surface or mix into the sandy seafloor and beaches. It ends up inside birds, fish, and other animals, harming them-and ultimately humans. Experts struggle with fear and hope as they work to stop the flood of plastic threatening living organisms across the globe.

An exciting new series based on the hit family game Pandemic begins with a deadly disease breaking out in darkest Peru - it's up to a crack team of experts to find the source before it spreads, in this taut airport thriller. Bodhi Patel is the brand new Lead Epidemiologist for the world's top epidemic specialists, Global Health Agency, but there's no time to settle in: his new boss, Helen Taylor, deploys GHA to contain a mysterious new killer virus spreading into Brazil. On the ground they learn that the virus is loose in a region controlled by a heavily armed drug warlord, and the race against time to discover a cure just got a whole lot tougher. Meanwhile, Bodhi finds himself with a newly reshuffled team still smarting from the changes, including his ex - the last person he expected to be working with.

"Here, my previous edition of Viruses, Plagues, & History is updated to reflect both progress and disappointment since that publication. This edition describes newcomers to the range of human infections, specifically, plagues that play important roles in this 21st century. The first is Middle East Respiratory Syndrome (MERS), an infection related to Sudden Acute Respiratory Syndrome (SARS). SARS was the first new-found plague of this century. Zika virus, which is similar to yellow fever virus in being transmitted by mosquitos, is another of the recent scourges. Zika appearing for the first time in the Americas is associated with birth defects and a paralytic condition in adults. Lastly, illness due to hepatitis viruses were observed prominently during the second World War initially associated with blood transfusions and vaccine inoculations. Since then, hepatitis virus infections have afflicted millions of individuals, in some leading to an acute fulminating liver disease or more often to a life-long persistent infection. A subset of those infected has developed liver cancer. However, in a triumph of medical treatments for infectious diseases, pharmaceuticals have been developed whose use virtually eliminates such maladies. For example, Hepatitis C virus infection has been eliminated from almost all (>97%) of its victims. This incredible result was the by-product of basic research in virology as well as cell and molecular biology during which intelligent drugs were designed to block events in the hepatitis virus life-cycle"--

Statistical Power Analysis is a nontechnical guide to power analysis in research planning that provides users of applied statistics with the tools they need for more effective analysis. The Second Edition includes: * a chapter covering power analysis in set correlation and multivariate methods; * a chapter considering effect size, psychometric reliability, and the efficacy of "qualifying" dependent variables and; * expanded power and sample size tables for multiple regression/correlation.