Personalized Predictive Modeling In Type 1 Diabetes

Personalized Predictive Modeling in Diabetes features state-of-the-art methodologies and algorithmic approaches which have been applied to predictive modeling of glucose concentration, ranging from simple autoregressive models of the CGM time series to multivariate nonlinear regression techniques of machine learning. Developments in the field have been analyzed with respect to: (i) feature set (univariate or multivariate), (ii) regression technique (linear or non-linear), (iii) learning mechanism (batch or sequential), (iv) development and testing procedure and (v) scaling properties. In addition, simulation models of meal-derived glucose absorption and insulin dynamics and kinetics are covered, as an integral part of glucose predictive models. This book will help engineers and clinicians to: select a regression technique which can capture both linear and non-linear dynamics in glucose metabolism in diabetes, and which exhibits good generalization performance under stationary and non-stationary conditions; ensure the scalability of the optimization algorithm (learning mechanism) with respect to the size of the dataset, provided that multiple days of patient monitoring are needed to obtain a reliable predictive model; select a features set which efficiently represents both spatial and temporal dependencies between the input variables and the glucose concentration; select simulation models of subcutaneous insulin absorption and meal absorption; identify an appropriate validation procedure, and identify realistic performance measures. Describes fundamentals of modeling techniques as applied to glucose control Covers model selection process and model validation Offers computer code on a companion website to show implementation of models and algorithms Features the latest developments in the field of diabetes predictive modeling

This contributed volume presents computational models of diabetes that quantify the dynamic interrelationships among key physiological variables implicated in the underlying physiology under a variety of metabolic and behavioral conditions. These variables comprise for example blood glucose concentration and various hormones such as insulin, glucagon, epinephrine, norepinephrine as well as cortisol. The presented models provide a powerful diagnostic tool but may also enable treatment via long-term glucose regulation in diabetics through closed-look model-reference control using frequent insulin infusions, which are administered by implanted programmable micro-pumps. This research volume aims at presenting state-of-the-art research on this subject and demonstrating the potential applications of modeling to the diagnosis and treatment of diabetes. The target audience primarily comprises research and experts in the field but the book may also be beneficial for graduate students.

This book tackles the problem of overshoot and undershoot in blood glucose levels caused by delay in the effects of carbohydrate consumption and insulin administration. The ideas presented here will be very important in maintaining the welfare of insulin-dependent diabetics and avoiding the damaging effects of unpredicted swings in blood glucose – accurate prediction enables the implementation of counter-measures. The glucose prediction algorithms described are also a key and critical ingredient of automated insulin delivery systems, the so-called “artificial pancreas”. The authors address the topic of blood-glucose prediction from medical, scientific and technological points of view. Simulation studies are utilized for complementary analysis but the primary focus of this book is on real applications, using clinical data from diabetic subjects. The text details the current state of the art by surveying prediction algorithms, and then moves beyond it with the most recent advances in data-based modeling of glucose metabolism. The topic of performance evaluation is discussed and the relationship of clinical and technological needs and goals examined with regard to their implications for medical devices employing prediction algorithms. Practical and theoretical questions associated with such devices and their solutions are highlighted. This book shows researchers interested in biomedical device technology and control researchers working with predictive algorithms how incorporation of predictive algorithms into the next generation of portable glucose measurement can make treatment of diabetes safer and more efficient.

The three-volume set of LNCS 11953, 11954, and 11955 constitutes the proceedings of the 26th International Conference on Neural Information Processing, ICONIP 2019, held in Sydney, Australia, in December 2019. The 173 full papers presented were carefully reviewed and selected from 645 submissions. The papers address the emerging topics of theoretical research, empirical studies, and applications of neural information processing techniques across different domains. The third volume, LNCS 11955, is organized in topical sections on semantic and graph based approaches; spiking neuron and related models; text computing using neural techniques; time-series and related models; and unsupervised neural models.

This book presents cutting-edge research and developments in the broad field of medical, biological engineering and computing. It gathers the second volume of the joint proceedings of the Mediterranean Conference on Medical and Biological Engineering and Computing (MEDICON) and the International Conference on Medical and Biological Engineering (CMBEBIH), which were held together on September 14-16, 2023, in Sarajevo, Bosnia and Herzegovina. Contributions report on innovative research and practices in molecular biology, tissue engineering and biotechnologies, covering not only medical but also industrial applications. Further, they describe advances in health technologies and medical devices, telemedicine, and robotic applications in clinical medicine and rehabilitation.

This book discusses the revolution of cycles and rhythms that is expected to take place in different branches of science and engineering in the 21st century, with a focus on communication and information processing. It presents high-quality papers in vibration sciences, rhythms and oscillations, neurosciences, mathematical sciences, and communication. It includes major topics in engineering and structural mechanics, computer sciences, biophysics and biomathematics, as well as other related fields. Offering valuable insights, it also inspires researchers to work in these fields. The papers included in this book were presented at the 1st International Conference on Engineering Vibration, Communication and Information Processing (ICoEVCI-2018), India.