Pharmacology Primer For Medications In Nuclear Medicine And Medical Imaging

It is the purpose and business of the pharmaceutical industry to dis cover, develop, and make available drugs for the care of the sick. The purpose of universities and national laboratories is to provide people and scientific knowledge that can help in the process. This book presents the combined efforts of scientists from the drug in dustry, academic laboratories and national laboratories to describe advances in radiotracer technology in studies on experimental ani mals and living human beings. The authors believe that the technol ogy is now ready for widespread application in the pharmaceutical industry. The goal of this book is to help bring this about. The field of Nuclear Medicine is based on the concept that, if treatment of disease is chemical, the patient's diagnosis should be chemical. Anatomy and histopathology have been the principle ba sis for making a diagnosis. Histopathologic data suffer from being descriptive, subjective, not quantifiable, and based on the study of dead tissue. The era of histopathology as the dominant concept in medical practice is coming to an end. Histopathologic findings are often heterogeneous and a single biopsy will at times not reveal the true nature of the disease, such as the grading of malignancy. Far greater accuracy of staging of disease and in the planning of treat ment is possible through chemistry, as well as by making possible a more suitable selection of a histological biopsy site.

A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States

Nuclear Medicine Therapy presents the state of the art in targeted radionuclide therapy, both in clinical practice and contemporary clinical investigation and trials. With contributions from an internationally-distinguished group of physicians and scientists, the book is devoted entirely to the use of nuclear medicine techniques and technology for therapy of malignant and benign diseases. Individual chapters cover the scientific principles and clinical applications of radionuclide therapy and the state of clinical trials of agents currently under investigation in the therapy of tumors involving virtually every organ system. Due to overlapping interest in techniques, indications, and clinical use, the development of radionuclide therapy attracts considerable input from other medical specialists whose collaboration is essential, including radiation and medical oncologists, hematologists, diagnostic radiologists, hepatologists, endocrinologists, and rheumatologists. And because radionuclide therapy is a rapidly evolving field of nuclear medicine, it is the aim of this volume to appeal to all specialists involved in targeted radionuclide therapy and to contribute to the standardization of the practice globally.

This book presents guidance on nuclear imaging. It offers details for each diagnosis, representative images, case data and current references.

This timely resource compares single-photon emission tomography (SPECT), used mainly withTechnetium and iodine for routine clinical examinations, and positron emission tomography(PET) , employing short-lived radionuclides of carbon, oxygen, nitrogen, and fluorine in researchinvestigations.Presenting the logic behind why one approach is better than another in various circumstances,Radio pharmaceuticals details the use of radiolabelled substrates in measuring the effect of diseaseand drugs on regional metabolism and receptor concentration/occupancy .. . discusses factorsaffecting the selective retention of small metal complexes by various tissues .. . analyzes the interactionof small exogenous metal complexes with enzymes in vivo and the critical role of stereochemistry. . . explores the use of radio labelled compounds in the study of neuroactive compounds,neurotransmitters, enzyme inhibitors, and substrates in vivo .. . covers the design and pharmacologyof radiolabelled drugs as probes of site of action , selectivity and specificity, and pharmacokineticsin vivo .. . and more.Extensively referenced with over l 050 bibliographic citations, Radiopharmaceuticals is a state-ofthe-art guide for pharmacists; organic, medicinal , and radiopharmaceutical chemists; pharmacokineticists;nuclear medicine physicians and technologists; neurochemists; and governmentregulatory personnel .

This text is a complete resource for all the imaging technologies, not just plain film radiography. It provides introductory material on pharmacological nomenclature, drug classifications, pharmacokinetics, and drugs used in imaging. It also offers comprehensive coverage of diagnostic contrast agents, along with drug administration procedures, emergency responses to drug reactions, and legal and ethical aspects of medication administration. Objectives and Key Terms open each chapter. Learning exercises include true/false, fill-in-the-blank, multiple-choice, and short-answer questions at the end of each chapter, with answers at the end of the book. Did You Know? boxes offer interesting tidbits of historical or current pharmacology information, connecting the book's drug content to everyday situations. Clinical Alert icons point out possible adverse reactions and toxic effects. Discussion of pharmacodynamics and drug classifications focuses on radiopaque contrast media used in imaging procedures, using clearly written text and useful tables. Pharmacokinetics coverage describes how drugs are absorbed, metabolized, distributed, and eliminated. Complete coverage of emergency procedures in response to adverse reactions to contrast media includes crash cart procedures and drugs used to treat cardiac and/or respiratory arrest and how to administer them appropriately. Updates on all contrast agents. New information on the use of contrast agents in ultrasound. New Drug Classifications chapter. New chapter on drug-related emergencies includes case studies. Evolve Resources for instructors include a 220-question test bank and an electronic image collection.

A new edition of a book is warranted when the book is successful and there are many new developments in the related discipline. Both have occurred for this book during the past 7 years since its second edition. The growth and development in nuclear pharmacy and radiopharmaceutical chemistry along with the continued success of the book have convinced us to update the book; hence this third edition. This book is a ramification of my nuclear pharmacy courses offered to pharmacy students specializing in nuclear pharmacy, nuclear medicine resi dents, and nuclear medicine technology students. The book is written in an integrated form from the basic concept of atomic structure to the practical clinical uses of radiopharmaceuticals. It serves both as a textbook on nu clear pharmacy for pharmacy students and nuclear medicine technologists, and as a useful reference book for many professionals related to nuclear medicine, such as nuclear medicine physicians and radiologists. The book contains 12 chapters. Each chapter is written as comprehen sively as possible based on my personal experience and understanding. At the end of each chapter, a section of pertinent questions and problems and so me suggested reading materials are included. I have made justifiably many additions and deletions as weIl as some reorganization in this edition. Chapter 3 is entirely dedicated to instru ments for radiation detection and measurement, including brief description of gas detectors, gamma-detecting instruments, and tomographic scanners.