Polio And Its Aftermath

In this book, Shell, himself a victim of polio, offers an inspired analysis of the disease. Part memoir, part cultural criticism and history, part meditation on the meaning of disease, Shell's work combines the understanding of a medical researcher with the sensitivity of a literary critic. He deftly draws a detailed yet broad picture of the lived experience of a crippling disease as it makes it way into every facet of human existence.

Childhood immunization is one of the major public health measures of the 20th century and is now receiving special attention from the Clinton administration. At the same time, some parents and health professionals are questioning the safety of vaccines because of the occurrence of rare adverse events after immunization. This volume provides the most thorough literature review available about links between common childhood vaccinesâ€"tetanus, diphtheria, measles, mumps, polio, Haemophilus influenzae b, and hepatitis Bâ€"and specific types of disorders or death. The authors discuss approaches to evidence and causality and examine the consequencesâ€"neurologic and immunologic disorders and deathâ€"linked with immunization. Discussion also includes background information on the development of the vaccines and details about the case reports, clinical trials, and other evidence associating each vaccine with specific disorders. This comprehensive volume will be an important resource to anyone concerned about the immunization controversy: public health officials, pediatricians, attorneys, researchers, and parents.

Vaccines have saved more lives than any other single medical advance. Yet today only four companies make vaccines, and there is a growing crisis in vaccine availability. Why has this happened? This remarkable book recounts for the first time a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, thathas led many pharmaceutical companies to abandon vaccine manufacture. Drawing on interviews with public health officials, pharmaceutical company executives, attorneys, Cutter employees, and victims of the vaccine, as well as on previously unavailable archives, Dr. Paul Offit offers a full account of the Cutter disaster. He describes the nation's relief when the polio vaccine was developed by Jonas Salk in 1955, the production of the vaccine at industrial facilities such as the one operated by Cutter, and the tragedy that occurred when 200,000 people were inadvertently injected with live virulent polio virus: 70,000 became ill, 200 were permanently paralyzed, and 10 died. Dr. Offit also explores how, as a consequence of the tragedy, one jury's verdict set in motion events that eventually suppressed the production of vaccines already licensed and deterred the development of new vaccines that hold the promise of preventing other fatal diseases.

From the 1930s to the 1950s, in response to the rising epidemic of paralytic poliomyelitis (polio), Texas researchers led a wave of discoveries in virology, rehabilitative therapies, and the modern intensive care unit that transformed the field nationally. The disease threatened the lives of children and adults in the United States, especially in the South, arousing the same kind of fear more recently associated with AIDS and other dread diseases. Houston and Harris County, Texas, had the second-highest rate of infection in the nation, and the rest of the Texas Gulf Coast was particularly hard-hit by this debilitating illness. At the time, little was known, but eventually the medical responses to polio changed the medical landscape forever. Polio also had a sweeping cultural and societal effect. It engendered fearful responses from parents trying to keep children safe from its ravages and an all-out public information blitz aimed at helping a frightened population protect itself. The disease exacted a very real toll on the families, friends, healthcare resources, and social fabric of those who contracted the disease and endured its acute, convalescent, and rehabilitation phases. In The Polio Years in Texas, Heather Green Wooten draws on extensive archival research as well as interviews conducted over a five-year period with Texas polio survivors and their families. This is a detailed and intensely human account of not only the epidemics that swept Texas during the polio years, but also of the continuing aftermath of the disease for those who are still living with its effects. Public health and medical professionals, historians, and interested general readers will derive deep and lasting benefits from reading The Polio Years in Texas.

The story of mankind's struggle against polio is compelling, exciting and full of twists and pardoxes. One of the grand challenges of modern medicine, it was a battleground between good and bad science. Gareth Williams takes an original view of the journey to understanding and defeating polio.

Polio--often called the "summer plague"--struck hundreds of thousands of children around the world between its emergence as an epidemic disease in 1916 to its cure in the 1950s. Today, images of children with crutches and leg braces or encased to their necks in iron lungs may be little more than a painful memory. Yet during its height the disease induced panic on a scale reminiscent of the great plagues of history. This book is the most comprehensive and compelling account of the century's polio epidemics yet written. Interweaving biographical, political, social, and medical history, Tony Gould--a distinguished British writer and himself a polio survivor--traces the rise and fall of the epidemics and describes the individuals who were influential in its treatment and conquest. He tells of Franklin D. Roosevelt, the most celebrated polio sufferer of all, who set up his own hydrotherapy center at Warm Springs in Georgia; John Enders, the Nobel prizewinner who made the crucial breakthrough in the laboratory; FDR's lieutenant, Basil O'Connor, whose "March of Dimes" became a byword for successful fund-raising; Sister Elizabeth Kenny, the larger-than-life nurse from the Australian outback who challenged medical orthodoxy and invented "miracle" cures; and finally the scientific rivals Jonas Salk and Albert Sabin, caught in a dramatic race to produce a viable vaccine. Gould then examines the experience of polio survivors on both sides of the Atlantic, including a moving autobiographical account of his own struggle with the disease and resulting disability. Although the disease has been eliminated in the West, it has not disappeared: paralytic polio remains a scourge in India, the Far East, and parts of Africa. And there are new worries that fatigue and accelerated muscular weakness--a "post-polio syndrome"--has come to afflict survivors three or four decades after the initial attack. Gould's powerful book, published forty years after the successful trial of the Salk vaccine, helps us to understand the savage and continuing impact of polio.

In 1988, the World Health Organization launched a twelve-year campaign to wipe out polio. Thirty years and several billion dollars over budget later, the campaign grinds on, vaccinating millions of children and hoping that each new year might see an end to the disease. But success remains elusive, against a surprisingly resilient virus, an unexpectedly weak vaccine and the vagaries of global politics, meeting with indifference from governments and populations alike. How did an innocuous campaign to rid the world of a crippling disease become a hostage of geopolitics? Why do parents refuse to vaccinate their children against polio? And why have poorly paid door-to-door healthworkers been assassinated? Thomas Abraham reports on the ground in search of answers.

In 1988, the World Health Organization launched a campaign for the global eradication of polio. Today, this goal is closer than ever. Fewer than 1,300 people were paralyzed from the disease in 2004, down from approximately 350,000 in 1988. In The Death of a Disease, science writers Bernard Seytre and Mary Shaffer tell the dramatic story of this crippling virus that has evoked terror among parents and struck down healthy children for centuries. Beginning in ancient Egypt, the narrative explores the earliest stages of research, describes the wayward paths taken by a long line of scientists-each of whom made a vital contribution to understanding this enigmatic virus-and traces the development of the Salk and Sabin vaccines. The book also tracks the contemporary polio story, detailing the remaining obstacles as well as the medical, governmental, and international health efforts that are currently being focused on developing countries such as India, Pakistan, Nigeria, and Niger. At a time when emerging diseases and the threat of bioterrorism are the focus of much media and public attention, this book tells the story of a crippling disease that is on the verge of disappearing. In the face of tremendous odds, the near-eradication of polio offers an inspiring story that is both encouraging and instructive to those at the center of the continued fight against communicable diseases.