Sertoli Cell Biology

Sertoli Cell Biology
Author: Michael D. Griswold
Publsiher: Academic Press
Total Pages: 488
Release: 2014-11-19
Genre: Science
ISBN: 9780124170483

Download Sertoli Cell Biology Book in PDF, Epub and Kindle

Sertoli Cell Biology, Second Edition summarizes the progress since the last edition and emphasizes the new information available on Sertoli/germ cell interactions. This information is especially timely since the progress in the past few years has been exceptional and it relates to control of sperm production in vivo and in vitro. Fully revised Written by experts in the field Summarizes 10 years of research Contains clear explanations and summaries Provides a summary of references over the last 10 years

Sertoli Cell Metabolism and Spermatogenesis

Sertoli Cell Metabolism and Spermatogenesis
Author: Pedro F. Oliveira,Marco G. Alves
Publsiher: Springer
Total Pages: 103
Release: 2015-11-29
Genre: Medical
ISBN: 9783319197913

Download Sertoli Cell Metabolism and Spermatogenesis Book in PDF, Epub and Kindle

This book is focused on Sertoli cell physiology and its role in the spermatogenic event. These cells, known as “nurse cells”, are essential for the normal development of germ cells by offering not only physical support and creating an immune-privileged environment, but also for providing nutritional support. The presence of Sertoli cells promotes the establishment of the appropriate microenvironment so that spermatogenesis may occur. Spermatogenesis maintenance in vivo is highly dependent on the metabolic cooperation established between Sertoli cells and developing germ cells. For many years this metabolic cooperation between testicular cells has been disregarded, but recent advances have highlighted the relevance of these processes for male fertility. Thus, the understanding of the functioning and regulation of these metabolic processes is a crucial step to identify key mechanisms associated with Sertoli cell (dys)function and to enlighten their influence on male fertility.

The Sertoli Cell

The Sertoli Cell
Author: Lonnie Dee Russell,Michael D. Griswold
Publsiher: Unknown
Total Pages: 840
Release: 1993
Genre: Sertoli cells
ISBN: UOM:39015029281964

Download The Sertoli Cell Book in PDF, Epub and Kindle

Sertoli Cells

Sertoli Cells
Author: Marco G. Alves,Pedro F. Oliveira
Publsiher: Humana
Total Pages: 297
Release: 2019-06-06
Genre: Science
ISBN: 1493985434

Download Sertoli Cells Book in PDF, Epub and Kindle

This detailed volume explores the use of Sertoli cells as models in male reproductive biology or as supporters for other cell types, and it answers the need for standardized protocols for their in vitro culture. Prepared for non-specialists as well as experienced researchers that may be interested in a multidisciplinary approach to study these cells, the book examines these remarkable cells that present some unique features that go far beyond the physical and nutritional support of spermatogenesis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Sertoli Cells: Methods and Protocols serves as a valuable resource for experienced researchers in reproductive biology, particularly andrologists, but also for future investigators and young students starting to study these extraordinary cells.

Regulation of Sertoli Cell and Germ Cell Differentiation

Regulation of Sertoli Cell and Germ Cell Differentiation
Author: R. Brehm,Klaus Steger
Publsiher: Springer Science & Business Media
Total Pages: 105
Release: 2005-12-12
Genre: Medical
ISBN: 9783540294467

Download Regulation of Sertoli Cell and Germ Cell Differentiation Book in PDF, Epub and Kindle

Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication.

Cell and Molecular Biology of the Testis

Cell and Molecular Biology of the Testis
Author: Claude Desjardins,Larry L. Ewing
Publsiher: Oxford University Press, USA
Total Pages: 524
Release: 1993
Genre: Medical
ISBN: 0195062698

Download Cell and Molecular Biology of the Testis Book in PDF, Epub and Kindle

This book is a comprehensive, multi-authored work on the structure and function of the mammalian testis. The approach emphasizes gene expression, translation and production of specific gene products and the cellular and molecular regulation of these fundamental processes. Rather than provide a global survey of all aspects of male reproduction, this book stresses specific mechanisms that underscore the structure and function of the testis. It explains old and new concepts from a cellular and molecular perspective. This novel approach allows the authors to forge links between cell and molecular biology and well-established aspects of spermatogenesis and steroidogenesis. The result is a well-focused, comprehensive, and synthetic analysis of testicular biology.

Sertoli Cells and Leydig Cells in Man

Sertoli Cells and Leydig Cells in Man
Author: Cornelia Schulze
Publsiher: Springer
Total Pages: 0
Release: 1984-09-01
Genre: Medical
ISBN: 3540136037

Download Sertoli Cells and Leydig Cells in Man Book in PDF, Epub and Kindle

The testis is composed of seminiferous tubules and interstitial tissue. The most important component of the interstitial tissue are the testosterone-producing Leydig cells. The seminiferous tubules contain the successive generations of germ cells, which can only exist in the presence of Sertoli cells. Sertoli cells mediate the effect of testosterone, which is indispensable for the maintenance of spermatogenesis. Consequently, the function of the Sertoli cells depends large lyon the function of the Leydig cells, and a local control mechanism between the two cell systems has been assumed. Sertoli cells are supposed to interfere with the regulation of Leydig cell hormone production (Aoki and Fawcett 1978; Sharpe et al. 1981). Few cell types of the testis have received as much attention in recent years as have the Sertoli cells. While comprehensive data had accumulated concerning the differentiation of germ cells, there was formerly little information available on the influence of Sertoli cells on this process. Only through recently developed methods and experimental approaches could their central role in spermatogene sis be verified. Sertoli cells are the only somatic cells in the seminiferous tubules. Their origin is still disputed (for references see Ritzen et al. 1981). They supposedly stem either from the coelomic epithelium or from mesenchymal cells of the genital ridges. According to Wartenberg (1978) they are derived from a gonadal blas tema containing cells from both the coelomic epithelium and the mesonephros.

Infertility in the Male

Infertility in the Male
Author: Larry I. Lipshultz,Stuart S. Howards,Craig S. Niederberger
Publsiher: Cambridge University Press
Total Pages: 691
Release: 2009-09-24
Genre: Medical
ISBN: 9781139483247

Download Infertility in the Male Book in PDF, Epub and Kindle

The new edition of this canonical text on male reproductive medicine will cement the book's market-leading position. Practitioners across many specialties - including urologists, gynecologists, reproductive endocrinologists, medical endocrinologists and many in internal medicine and family practice – will see men with suboptimal fertility and reproductive problems. The book provides an excellent source of timely, well-considered information for those training in this young and rapidly evolving field. While several recent books provide targeted 'cookbooks' for those in a male reproductive laboratory, or quick reference for practising generalists, the modern, comprehensive reference providing both a background for male reproductive medicine as well as clinical practice information based on that foundation has been lacking until now. The book has been extensively revised with a particular focus on modern molecular medicine. Appropriate therapeutic interventions are highlighted throughout.