Six Years After Anthrax

The vaccine used to protect humans against the anthrax disease, called Anthrax Vaccine Adsorbed (AVA), was licensed in 1970. It was initially used to protect people who might be exposed to anthrax where they worked, such as veterinarians and textile plant workers who process animal hair. When the U. S. military began to administer the vaccine, then extended a plan for the mandatory vaccination of all U. S. service members, some raised concerns about the safety and efficacy of AVA and the manufacture of the vaccine. In response to these and other concerns, Congress directed the Department of Defense to support an independent examination of AVA. The Anthrax Vaccine: Is It Safe? Does It Work? reports the study's conclusion that the vaccine is acceptably safe and effective in protecting humans against anthrax. The book also includes a description of advances needed in main areas: improving the way the vaccine is now used, expanding surveillance efforts to detect side effects from its use, and developing a better vaccine.

Witnesses: Jay Cohen, Under Sec. for Science and Technology, Dept. of Homeland Security; Gerald Parker, Principal Deputy Assistant Sec., Office of the Assistant Sec. for Preparedness and Response, Dept. of Health and Human Services; Keith Rhodes, Dir., Center for Technology and Engineering, Applied Research and Methods, GAO; Tara O¿Toole, Dir., Center for Biosecurity, Univ. of Pittsburgh Medical Center. Appendix: Slides submitted for the Record from Mr. Cohen; Questions and responses for the record from the witnesses; Report to Congressional Requesters, ¿Project Bioshield -- Actions Needed to Avoid Repeating Past Problems with Procuring New Anthrax Vaccine and Managing the Stockpile of Licensed Vaccine,¿ Oct. 2007. Illustrations.

This fourth edition of the anthrax guidelines encompasses a systematic review of the extensive new scientific literature and relevant publications up to end 2007 including all the new information that emerged in the 3-4 years after the anthrax letter events. This updated edition provides information on the disease and its importance, its etiology and ecology, and offers guidance on the detection, diagnostic, epidemiology, disinfection and decontamination, treatment and prophylaxis procedures, as well as control and surveillance processes for anthrax in humans and animals. With two rounds of a rigorous peer-review process, it is a relevant source of information for the management of anthrax in humans and animals.

This book documents and reveals new information about the anthrax attacks of 2001. Decker provides first-hand perspective detailing the new science, microbial forensics, and parts of the investigation unknown to the public.

Less than a month after the September 11, 2001 attacks, letters containing spores of anthrax bacteria (Bacillus anthracis, or B. anthracis) were sent through the U.S. mail. Between October 4 and November 20, 2001, 22 individuals developed anthrax; 5 of the cases were fatal. During its investigation of the anthrax mailings, the FBI worked with other federal agencies to coordinate and conduct scientific analyses of the anthrax letter spore powders, environmental samples, clinical samples, and samples collected from laboratories that might have been the source of the letter-associated spores. The agency relied on external experts, including some who had developed tests to differentiate among strains of B. anthracis. In 2008, seven years into the investigation, the FBI asked the National Research Council (NRC) of the National Academy of Sciences (NAS) to conduct an independent review of the scientific approaches used during the investigation of the 2001 B. anthracis mailings. Review of the Scientific Approaches Used During the FBI's Investigation of the Anthrax Letters evaluates the scientific foundation for the techniques used by the FBI to determine whether these techniques met appropriate standards for scientific reliability and for use in forensic validation, and whether the FBI reached appropriate scientific conclusions from its use of these techniques. This report reviews and assesses scientific evidence considered in connection with the 2001 Bacillus anthracis mailings.

For the first time, Pulitzer Prize–winning journalist David Willman tells the whole gripping story of the hunt for the anthrax killer who terrorized the country in the dark days that followed the September 11th attacks. Letters sent surreptitiously from a mailbox in New Jersey to media and political figures in New York, Florida, and Washington D.C. killed five people and infected seventeen others. For years, the case remained officially unsolved—and it consumed the FBI and became a rallying point for launching the Iraq War. Far from Baghdad, at Fort Detrick, Maryland, stood Bruce Ivins: an accomplished microbiologist at work on patenting a next-generation anthrax vaccine. Ivins, it turned out, also was a man the FBI consulted frequently to learn the science behind the attacks. The Mirage Man reveals how this seemingly harmless if eccentric scientist hid a sinister secret life from his closest associates and family, and how the trail of genetic and circumstantial evidence led inexorably to him. Along the way, Willman exposes the faulty investigative work that led to the public smearing of the wrong man, Steven Hatfill, a scientist specializing in biowarfare preparedness whose life was upended by media stakeouts and op-ed-page witch hunts. Engrossing and unsparing, The Mirage Man is a portrait of a deeply troubled scientist who for more than twenty years had unlimited access to the U.S. Army’s stocks of deadly anthrax. It is also the story of a struggle for control within the FBI investigation, the missteps of an overzealous press, and how a cadre of government officials disregarded scientific data while spinning the letter attacks into a basis for war. As The Mirage Man makes clear, America must, at last, come to terms with the lessons to be learned from what Bruce Ivins wrought. The nation’s security depends on it. From the Hardcover edition.

This book uses the 2001 anthrax attacks as its point of departure for an analysis of the past, present, and future of America's preparedness to deal with major challenges to public health, including bioterrorism and pandemic flu. The study identified the strength and weaknesses of the system while making recommendations for improvements. This allows the U.S. to be better prepared if faced with a larger or different biological threat. This book looks for linkages not only between bioterrorists and pandemic defenses, but also between public health security and the wider field of homeland security. Johnstone highlights some key foundation plans and strategies that are to serve as a basis for public health security. Failure to address these crucial issues not only creates unfounded mandates but also inhibits priority setting, leadership, and accountablity. Bioterror: Anthrax, Influenza, and the Future of Public Health Security utilizes a large number of sources from within both the public health and public policy communities to document how each sector responded to the anthrax attacks and re-emergent infectious diseases, and how those responses have evolved to the present day, As with other areas of homeland security, sustained progress in public health security is not likely until basic questions about funding priorities and leadership are successfully addressed. In the response to the only mass casualty event in the United States since 2001, Hurricane Katrina, and in various emergency simulation exercises such as TOPOFF series, major performance deficiencies have been observed. This book brings together a variety of sources, the best available evidence on the status of the public health security system at three distinct points: before 2001; during and immediately after the anthrax attacks; and in the period from 2004 to the present.