Translational Neuroimmunology Volume 7

Translational Neuroimmunology  Volume 7
Author: Nima Rezaei,Niloufar Yazdanpanah
Publsiher: Elsevier
Total Pages: 542
Release: 2023-06-18
Genre: Medical
ISBN: 9780323900713

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Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish. All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research. Gives an introduction on neuroimmunological diseases, from bench to bedside Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system Proves changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases

Translational Neuroimmunology in Multiple Sclerosis

Translational Neuroimmunology in Multiple Sclerosis
Author: Ruth Arnon,Ariel Miller
Publsiher: Academic Press
Total Pages: 504
Release: 2016-05-10
Genre: Science
ISBN: 9780128020074

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Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development. Provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis and the translation of this research to immunotherapy treatment Edited by renowned leaders in the field of neuroimmunology and multiple sclerosis Contains the latest resource material for basic and clinical scientists and practitioners in neuroscience, neurology, immunology, and pharmacology

Translational Neuroimmunology Volume 8

Translational Neuroimmunology  Volume 8
Author: Nima Rezaei,Niloufar Yazdanpanah
Publsiher: Elsevier
Total Pages: 272
Release: 2023-06-18
Genre: Medical
ISBN: 9780443185793

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Translational Neuroimmunology: Multiple Sclerosis provides an update on bench to bedside studies on Multiple Sclerosis as an autoimmune disease. Divided into twelve chapters, the book begins with an in-depth introduction to the neuroimmunology and immunopathology of multiple sclerosis. Sections also provide content on genetics and epigenetics, the microbiome, diagnosis, and treatment of multiple sclerosis. Finally, various precision treatments are covered. All information is presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research. Provides an introduction on multiple sclerosis as an autoimmune disease, from bench to bedside Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system Shows the changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases

Update on Translational Neuroimmunology Research of ISNI 2018

Update on Translational Neuroimmunology   Research of ISNI 2018
Author: Sandra Amor,Fabienne Brilot,David Brown,Judith M. Greer,Marc J. Ruitenberg
Publsiher: Frontiers Media SA
Total Pages: 253
Release: 2020-12-29
Genre: Medical
ISBN: 9782889662951

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The 14th International Congress of Neuroimmunology, ISNI 2018, was held in August 2018 in Brisbane, Australia, and is a biennial event organized by the International Society of Neuroimmunology (ISNI). The theme of ISNI 2018 was “Travelling the Neuroimmunological Translational Highway”, and the Congress highlighted many research discoveries that bridge the gap between basic and clinical sciences, and which impact our understanding of pathogenic immune-mediated mechanisms in diseases affecting the nervous system. In this Research Topic, we aim to give a comprehensive overview of topics highlighted at the Congress, showcasing the current state of the field of neuroimmunology and where it is going in the near future.

Translational Neuroimmunology From Disease Mechanisms to Clinical Applications

Translational Neuroimmunology  From Disease Mechanisms to Clinical Applications
Author: Silva Lyman
Publsiher: American Medical Publishers
Total Pages: 0
Release: 2023-09-26
Genre: Health & Fitness
ISBN: 9798887405278

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Neuroimmunology is a field that combines neuroscience, the study of the nervous system and immunology, the study of the immune system, into one discipline within this field neuroimmunology. The interaction of these two complex systems is studied the neuroimmunologists throughout development, homeostasis, and response to injuries. The adaptive and innate immune systems continuously monitor the nervous system. The immune system identifies and responds to changes in cell identity and neural connectivity during development and adult life. The immune system and nervous system require suitable degrees of cellular differentiation, organizational integrity, and neural network connectivity. Pro-inflammatory cytokines which are released by activated macrophages and monocytes during infection, can impact neural targets that control thermogenesis, behavior, sleep, and mood. Cytokines are produced in the central nervous system due to brain injury, during bacterial and viral infections, and neurodegenerative processes. This book is a valuable compilation of topics, ranging from the basic to the most complex advancements in the field of translational neuroimmunology. It includes contributions of experts and scientists which will provide innovative insights on neuroimmunology and its clinical applications. This book will provide comprehensive knowledge to the readers.

Neuroimmunology

Neuroimmunology
Author: Jeremy Brockes
Publsiher: Springer Science & Business Media
Total Pages: 256
Release: 2013-03-09
Genre: Medical
ISBN: 9781468441901

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Neuroimmunology could be defined as the application of immunological methods to problems in neurobiology but such a definition is so all encompassing as to be unhelpful. It is not a precisely circumscribed discipline but it seems worthwhile at the outset to point to three of the major areas of activity. One rather early use of the term was in connection with studies on the immune response to antigens in the nervous system. This includes topics such as autoimmunity in the central and peripheral nervous sys tems, the response to neural tumors or viral infections, and the im munopathology of such processes. Although not at the forefront of the currently fashionable preoccupation with neuroimmunology, this area continues to be a vital and interesting one from both clinical and basic perspectives. A second very active area is the exploitation of antibodies to iden tified components of neural cells, and in particular to those molecules involved as neurotransmitters, in transmitter synthesis and breakdown, and as synaptic receptors. The immunohistochemical detection of these antigens has led to new insights into the functional organization of the nervous system, and reference to such studies is almost a sz'ne qua non for discussions of most central and peripheral synapses.

Translational Inflammation

Translational Inflammation
Author: Anonim
Publsiher: Academic Press
Total Pages: 294
Release: 2018-11-24
Genre: Medical
ISBN: 9780128138335

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Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application

Clinical Neuroimmunology

Clinical Neuroimmunology
Author: Jack P. Antel
Publsiher: Unknown
Total Pages: 467
Release: 2005
Genre: Medical
ISBN: 9780198510680

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Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches todisease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. It is a fast moving field and this is the most up to date text available. Chaptersare dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous systems, including important neurodegenerative diseases (such as multiple sclerosis and HIV-related neural degeneration) which cause life-long disability. Extensive coverage is given to awhole array of immune-directed therapies.The book has a strong international team of well respected, high profile editors and authors. The first edition published to extensive and positive reviews and has established itself as the principal reference source in the field. This second edition summarizes recent advances in clinicalneuroimmunology in a comprehensive and unbiased way.