Translational Toxicology and Therapeutics

Translational Toxicology and Therapeutics
Author: Michael D. Waters,Claude L. Hughes
Publsiher: John Wiley & Sons
Total Pages: 790
Release: 2018-01-04
Genre: Medical
ISBN: 9781119023609

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Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

Translational Toxicology

Translational Toxicology
Author: Claude L. Hughes,Michael D. Waters
Publsiher: Humana Press
Total Pages: 380
Release: 2016-03-23
Genre: Medical
ISBN: 9783319274492

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Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.

Translational Toxicology and Therapeutics

Translational Toxicology and Therapeutics
Author: Claude L. Hughes
Publsiher: Unknown
Total Pages: 135
Release: 2018
Genre: MEDICAL
ISBN: 1119023645

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Translational Toxicology and Therapeutics

Translational Toxicology and Therapeutics
Author: Michael D. Waters,Claude L. Hughes
Publsiher: John Wiley & Sons
Total Pages: 784
Release: 2017-11-10
Genre: Medical
ISBN: 9781119023715

Download Translational Toxicology and Therapeutics Book in PDF, Epub and Kindle

Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

The Coronavirus Pandemic and the Future Virology Epidemiology Translational Toxicology and Therapeutics Volume 1

The Coronavirus Pandemic and the Future  Virology  Epidemiology  Translational Toxicology and Therapeutics  Volume 1
Author: Michael D. Waters,Alok Dhawan,Tim Marrs,Diana Anderson,Stafford Warren,Claude L. Hughes
Publsiher: Royal Society of Chemistry
Total Pages: 595
Release: 2022-04-27
Genre: Medical
ISBN: 9781839163067

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By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.

The Coronavirus Pandemic and the Future Virology Epidemiology Translational Toxicology and Therapeutics Volume 2

The Coronavirus Pandemic and the Future  Virology  Epidemiology  Translational Toxicology and Therapeutics  Volume 2
Author: Claude L. Hughes,Stafford Warren,Diana Anderson,Tim Marrs,Alok Dhawan,Michael D. Waters
Publsiher: Royal Society of Chemistry
Total Pages: 695
Release: 2022-04-27
Genre: Medical
ISBN: 9781839166785

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This second volume chronicles the later stages of the outbreak of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures highliting the response from specific coutries of note and efforts to repurpose and produce new therapeutics and vaccines. By addressing considerations of efficacy and safety of drugs and chemicals used to combat COVID-19, virtually in real-time, this book documents and highlights the advances in science and place the toxicology, pharmaceutical science, public health and medical community in a better position to advise in future epidemics.

Toxicoepigenetics

Toxicoepigenetics
Author: Shaun D. McCullough,Dana Dolinoy
Publsiher: Academic Press
Total Pages: 428
Release: 2018-11-02
Genre: Medical
ISBN: 9780128124345

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Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study. Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications

Principles of Translational Science in Medicine

Principles of Translational Science in Medicine
Author: Martin Wehling
Publsiher: Academic Press
Total Pages: 364
Release: 2015-04-02
Genre: Science
ISBN: 9780128007211

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Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions