Understanding Irritable Bowel Syndrome

A Comprehensive Overview of Irritable Bowel Syndrome: Clinical and Basic Science Aspects presents up-to-date knowledge in the field and provides a comprehensive summary of this area of study, including an overview on IBS, starting from its pathogenesis, including genetic, microbial and physiological background, through symptom recognition, diagnosis and IBS treatment, both non-pharmacological and pharmacological. Compiles the most recent and comprehensive findings in pharmacological targets Highlights the role of extrinsic and intrinsic factors involved in disease development Written by leading researchers in the field of Irritable Bowel Syndrome to address research challenges in the field Includes bonus information on symptom recognition and diagnosis

Irritable Bowel Syndrome (IBS) is an extremely common disorder affecting around 20% of the population of Western. Understanding Irritable Bowel Syndrome offers you a comprehensive, review of what is known about IBS and its treatment. Written in easy-to-understand language by an IBS expert, the book contains numerous examples and real-life quotes from sufferers. Simon Darnley not only provides you with strategies for coping with this condition physically, he also deals with the psychological aspects of IBS to help you cope better mentally with the problem. ? Written in an easy-to-understand fashion by an expert in the subject ? Contains numerous examples and real-life quotes from IBS sufferers ? An invaluable guide for anyone suffering from IBS Simon Darnley is a cognitive behavioural therapist (CBT) and researcher with over fifteen years' experience. For seven years he was a tutor in CBT at the Institute of Psychiatry in London and has recently completed a large research trial using cognitive behavioural therapy for IBS. He is also a part-time magician and comedian.

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, but it is puzzling for those who have it and for the doctors who treat it. There is no test that can show whether or not you have IBS, however treatment can relieve the symptoms and help sufferers live with it.

This book provides all that the family doctor requires to successfully diagnose irritable bowel syndrome and to manage patients with confidence and sensitivity. Both authors are renowned experts recognised not only for their contribution to our current understanding of functional bowel disorders but also for their clear and informative writing style. Includes all key information on causes and mechanisms, diagnosis and management. Offers invaluable tips on history taking and patient interaction. Succinct, expert presentation of the clinical application of the results of an abundance of recent research. An invaluable tool for the diagnosis and treatment of patients in the primary care setting. An insightful review of future developments in diagnosis and treatment including 'alternative' treatments. Contents: • What is IBS? • Epidemiology • Causes and mechanisms • Diagnosis; Approach to treatment • Dietary advice • Drug treatment • Psychological treatment • Future trends.

IBS affects almost one in six Americans and is characterized by abdominal pain, bloating, gas, and diarrhea or constipation. Today physicians are better able to diagnose this complex disorder, understand and explain its origins, and develop a treatment plan that effectively meets the individual needs of a patient. Since publication of the first edition of Making Sense of IBS, diagnosis and treatment of irritable bowel syndrome have changed significantly. Drawing on his many years of experience treating people who have symptoms of IBS, Dr. Brian E. Lacy has greatly expanded the first edition, adding new topics and the latest findings on tests, medications, alternative treatments, dietary factors, and lifestyle. Dr. Lacy explains normal digestion, the causes of IBS, how IBS is diagnosed, and what to expect with treatment. He also explores special topics such as IBS in children and psychological, hypnotherapeutic, and psychiatric therapies. Important new information in the second edition includes: the roles of fiber, gluten, lactose, and fructose in the development and treatment of IBS; the use of probiotics and antibiotics to treat IBS; similarities and differences between IBS and inflammatory bowel disease (IBD); the relationship between small intestine bacterial overgrowth and IBS; how to make the most of your visits to a gastroenterologist; and lifestyle modifications that can improve symptoms of IBS.

This book provides comprehensive and up-to-date insights into emerging trends in research and treatment of irritable bowel syndrome (IBS). Key features include pathogenesis, existing and new therapies, as well as nonpharmacological approach in management of IBS. The authors are known experts who contributed significantly for a better understanding of the etiology of IBS as one of the most commonly diagnosed functional disorders. This book provides a state-of-the-art review of different aspects of IBS and is recommended to healthcare providers, clinical scientists, general practitioners, students, and patients.

This comprehensive yet concise guide to the diagnosis and management of IBS is divided into four main parts: Overview, Diagnosis, Symptom-specific Treatment, and What's Next in IBS. Each chapter includes a summary of key points, and most chapters include cases and multiple choice questions for rapid review. Clinicians who manage patients with IBS will want to keep this dependable reference close at hand.

Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.