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Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.

Analysis of 18th- and 19th-Century Musical Works in the Classical Tradition is a textbook for upper-level undergraduate and graduate courses in music analysis. It outlines a process of analyzing works in the Classical tradition by uncovering the construction of a piece of music—the formal, harmonic, rhythmic, and voice-leading organizations—as well as its unique features. It develops an in-depth approach that is applied to works by composers including Haydn, Mozart, Beethoven, Schubert, Schumann, and Brahms. The book begins with foundational chapters in music theory, starting with basic diatonic harmony and progressing rapidly to more advanced topics, such as phrase design, phrase expansion, and chromatic harmony. The second part contains analyses of complete musical works and movements. The text features over 150 musical examples, including numerous complete annotated scores. Suggested assignments at the end of each chapter guide students in their own musical analysis.

The poor and the sick-poor have always presented a problem to the governments and churches of Europe. Whose responsibility are they? Are they a wilful burden on the honest working population, or are they a necessary presence for the true Christian to live the true Christian life? In the 18th and 19th centuries what happened to the poor and the sick-poor in the north and south of Europe was different. In the north there occurred first the Reformation in the 16th century, which changed attitudes to the poor, and then the advent of industrialisation, with its far-reaching effects of pauperisation of people both in town and countryside. In the Catholic south, where industrialisation did not appear so soon, the Catholic Church introduced a programme of reform at all levels but along traditional lines. This included the founding of new orders dedicated to the care of the poor and sick, of new institutions within which to house and care for them. At all times it was taken for granted that it was a necessary aspect of being a Christian that one should give for the care of the needy, and that this was not the duty of the state or of secular institutions. The secularising movement did however reach the southern countries by way both of the Enlightenment and - more drastically - in the form of the Napoleonic invasions. But after the defeat of Napoleon, the Church reasserted its right to administer and control the support of the poor and sick, and this situation continued until 1900 in most areas. Moreover the effects of industrialisation and the concomitant increase in population did make itself felt in the south in the course of the 19th century, which put great stress on the institutions for poor relief and health care for the poor. All this is still relevant today, since the situations that governments and the Catholic Church found themselves confronted with, and the stark choices they had to make, are being replayed to some extent today. Who is responsible for the poor, who is to blame for their being poor? How should their poverty be relieved, how should the health care of the many be funded? These are still live issues today. While complete in itself the present volume also forms the fourth and last of a four-volume survey of health care and poor relief in Europe between 1500 and 1900, edited by Ole Peter Grell and Andrew Cunningham