Advances In Skeletal Reconstruction Using Bone Morphogenetic Proteins

The bone morphogenetic protein (BMP) is a special growth factor for the induction of new bone formation. Today, the extract of the BMP originating from bone tissue as well as genetically modified BMPs, particularly BMP-2 and -7, can be used.Though the BMP as an implant is as yet an unregistered drug or medical tool in Europe and the US, specialists are confident that it will obtain final government approval based on the results of clinical tests conducted on more than 3000 patients.This important book focuses mainly on the clinical BMP treatment of patients OCo namely in orthopaedic cases (fractures, bone transplants, non-unions and pseudoarthroses), maxillofacial surgery (sinus lift before dental implantation), dental surgery (filling out of cavities) and spinal surgery (using a BMP implant instead of the patient's own bone)."

From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of scientific topics, including biochemistry, biology, molecular biology and preclinical animal studies on spinal fusion, cartilage repair, craniofacial and dental reconstruction using BMPs, as well as approved clinical applications in human bone non-unions. This book provides a resource not only for experts in the field, but also for undergraduate students, newcomers and clinicians worldwide, given that the use of BMPs in orthopedic reconstruction has been already approved in Europe, Australia, Canada and the USA.

The bone morphogenetic protein (BMP) is a special growth factor for the induction of new bone formation. Today, the extract of the BMP originating from bone tissue as well as genetically modified BMPs, particularly BMP-2 and -7, can be used. Though the BMP as an implant is as yet an unregistered drug or medical tool in Europe and the US, specialists are confident that it will obtain final government approval based on the results of clinical tests conducted on more than 3000 patients. This important book focuses mainly on the clinical BMP treatment of patients — namely in orthopaedic cases (fractures, bone transplants, non-unions and pseudoarthroses), maxillofacial surgery (sinus lift before dental implantation), dental surgery (filling out of cavities) and spinal surgery (using a BMP implant instead of the patient's own bone). Contents:Induction of Osteogenic Potential of Fibroblasts by Transfection of rhBMP-2 (X Si et al.)Determination of the Biological Activity of BMP in Cell Cultures is Unreliable (M Ulmanen et al.)Different Configurations of Bioactive Silica Glass as Carrier for BMP (T C Lindholm)Developing a Bioimplant of Coral and Extracted BMP for Clinical Use (T S Lindholm et al.)Exogenous and Endogenous OP-1 in Articular Cartilage (S Chubinskaya & K E Kuettner)Effect of BMP Around Dental Implant (K Bessho & J L Ong)Mandibular Reconstruction Using Naturally Derived BMPs: A Clinical Trial Report (U Ripamonti & C Ferretti)BMPs in Oral Clinical Application (E Lourenco)The Use of OP-1 in Resistant Pseudoarthrosis: Eight Case Reports (G H G Dekkers et al.)Fractures of the Thoracolumbar Spine and Prospects of Consecutive Spinal Fusion Enhancement by Means of BMP (T R Blattert)and other papers Readership: Researchers in the fields of growth factors, biomaterials and genetics, as well as dentists, orthopaedic, maxillofacial and spinal surgeons. Keywords:Skeletal Reconstruction;Bone Morphogenetic Proteins-Extraxts and Recombinants;Fracture Repair;Delayed Bone Union;Bone Lenghtening;Dental Implants;Bone Defects;Spinal Fusion;Cartilage Repair;Mandibular-Maxillar and Skull Defects

Current clinical orthopedic practice requires practitioners to have extensive knowledge of a wide range of disciplines from molecular biology to bioengineering and from the application of new methods to the evaluation of outcome. The biomechanics of and biomaterials used in orthopedics have become increasingly important as the possibilities have increased to treat patients with foreign material introduced both as optimized osteosynthesis after trauma and as arthroplasties for joint diseases, sequelae of trauma or for tumor treatment. Furthermore, biomaterial substitutes are constantly being developed to replace missing tissue. Biomechanics and Biomaterials in Orthopedics provides an important update within this highly important field. Professor Dominique Poitout has collected a series of high-quality chapters by globally renowned researchers and clinicians. Under the auspices of the International Society of Orthopaedic Surgery and Traumatology (SICOT) and International Society of Orthopaedic and Traumatology Research (SIROT), this book now provides permanent and specific access to the considerable international knowledge in the field of locomotor system trauma and disease treatment using the novel bioengineering solutions. This book covers both basic concepts concerning biomaterials and biomechanics as well as their clinical application and the experience from everyday practical use. This book will be of great value to specialists in orthopedics and traumatology, while also provide an important basis for graduate and postgraduate learning.

The effects of the bone morphogenetic proteins (BMPs) family on bone formation are well documented, but the transforming growth factor (TGF)-beta (β) isoforms are much less studied. The product of 20 years of study, Induction of Bone Formation in Primates: The Transforming Growth Factor-β3 sums up editor Ugo Ripamonti’s research into the osteogenic activity of the three mammalian TGF-β isoforms, particularly in primates. It explores how the mammalian TGF-β isoforms have the potential to shed light on the apparent redundancy of bone induction signaling. The book unearths the profound and important bone inductive activity of the TGF-β3 isoform. It includes accounts of extensive research in non-human primates from craniofacial tissue regeneration, heterotopic tissue induction, and chapters on periodontal tissue regeneration and synergistic induction of bone formation. It also discusses the future clinical role of the TGF-β isoform, including in human studies. This book contributes to the fascinating history of BMP and TGF-β research at the intersection of molecular biology, tissue induction, bone regeneration, and craniofacial surgery. It provides a revolutionary awakening to new possibilities in skeletal reconstruction, tissue engineering, and molecular and cellular biology.

With its focus on industrial pharmaceutical research, written by international experts from the industry, this book fills in a gap in the existing literature. It reflects the combination of such pharmaceutical interests as drug delivery, drug targeting, quality and safety management, drug approval and regulation, patenting issues and biotechnology fundamentals. Thus it provides practitioners in pharmaceutical biotechnology with all the relevant information from the shelf. The first part offers a comprehensive survey and review of the rapidly increasing array of biopharmaceuticals derived from the molecular biological approaches now widely available. This is followed by an extra section devoted to the very critical patenting and drug regulation issues. The whole is rounded off by detailed monographs of biotechnologically developed drugs that are already on the market. With a foreword of by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at the Massachusetts Institute of Technology. In 2002, he received the Charles Stark Draper Prize, the highest recognition for an engineer. Professor Langer is member of all three national academies - the Institute of Medicine, the National Academy of Engineering, and the National Academy of Sciences: "The book attempts to provide a balanced view of the biotechnological industry and the number of experts from industry sharing their knowledge and experience with the audience gives the book an outstanding value. All contributors provide with each chapter an up-to-date review on key topics in pharmaceutical biotechnology. This work is not only a valuable tool for the industrial expert but also for all pharmacists and scientists from related areas who wish to work with biotech drugs."

Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.