Advancing Development

This book reflects on current thinking in development economics and on what may happen over the next two decades. As well as studying development economics in retrospect, the volume explores the current debates and challenges and looks forward at the problems that affect the global capacity to achieve the Millennium Development Goals.

This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.

A Guide for governments and stakeholders seeking to strengthen the contribution of sport to development and peace work. Part 1 provides evidence-based analysis of the potential contribution of sport to development objectives. Part 2 provides a practical framework for analysis, planning and monitoring of sport in development and peace work.

Within the field of academic development, the last twenty years have seen a great expansion of published research into practice and the further development of theoretical approaches. This growth in the scholarship of academic development matches a growth in the scholarship of teaching and learning. Advancing Practice in Academic Development draws on these evolving scholarships to advance professional practice in academic development, addressing questions such as: . How have global academic developers and their units developed and changed over recent decades? How has the context in which academic development work is done altered? What have academic developers and their professional associations learnt? Case studies and examples are used throughout the text to illustrate development scenarios and methods. Academic development is considered as, among others, a critical, a scholarly, a principled, a pragmatic, a supporting and a leadership role. This book is ideal for use on academic development courses run by SEDA and other international organisations as well as by those who have responsibility for leading the improvement of educational practice. Written in a scholarly, accessible, stimulating and practical style, this book acknowledges difficulties and offers ways forward. As well as analysing problems, it offers solutions. Links to web sources referenced in this book can be found at www.seda.ac.uk/apad

Proficiency in Bootstrap, AJAX, and jQuery is paramount in modern web development due to their significant contributions to creating engaging and functional web applications. Bootstrap, with its extensive library of pre-designed components and responsive grid system, expedites UI development while ensuring consistency and adaptability across various devices and screen sizes. AJAX empowers developers to implement dynamic and asynchronous communication between the client and server, enabling real-time updates without requiring full page reloads. This enhances user experience by providing smoother interactions and reducing latency, crucial for today's fast-paced digital environments. Further, jQuery simplifies client-side scripting by abstracting complex JavaScript operations into concise and reusable functions, facilitating efficient DOM manipulation, event handling, and AJAX requests. Mastery of these technologies not only aligns developers with industry standards but also enhances the employability opportunities by demonstrating their ability to create visually appealing, responsive, and interactive web applications that meet the evolving demands of users and businesses alike in the competitive web development landscape. This book offers a comprehensive hands-on experience designed to equip readers with mastery over fundamental concepts in web development.

This book is the first systematic analysis of Russia's poverty and living standards since the country's independence. Its primary goal is to quantify the nature and extent of changes in the welfare of Russians during the course of transition and beyond. Part 1 establishes the economic and methodological framework within which poverty in the Russian Federation is studied. Part 2 comprises a series of chapters that analyze poverty profiles and trends, ranging across monetary and non-monetary indicators. Part 3 addresses selected critical aspects of the system of social support in the impact of public transfers, the extent of private interhousehold transfers, and public opinion about social problems.

This book explores the potential responsibilities to respect, protect and fulfill international human rights law (IHRL) of a particular class of non-state actors: non-governmental organizations (NGOs). It calls for NGOs pursuing development to respect and fulfill the human right of genocide survivors to reparative justice in Rwanda. It argues that NGOs have social and moral responsibilities to respect and fulfill IHRL, and for greater accountability for them to do so. The book focuses on those NGOs advancing development in a post genocide transitional justice context acting simultaneously in partnership with state governments, as proxies and agents for these governments, and providing essential public goods and social services as part of their development remit. It defines development as a process of expanding realization of social, economic, and cultural rights addressing food security, economic empowerment/poverty reduction, healthcare, housing, education, and other fundamental human needs while integrating these alongside the expansion of freedoms and protections afforded by civil and political rights. It uses post genocide Rwanda as a case study to illustrate how respect and fulfillment of the IHRL pertaining to reparative justice are hindered by failing to hold NGOs responsible for IHRL. Consequently, this results in discrimination against, marginalization, and the disadvantaging of survivors of the Rwandan genocide against the Tutsi and violations of their human rights.

This handbook examines positive youth development (PYD) in youth and emerging adults from an international perspective. It focuses on large and underrepresented cultural groups across six continents within a strengths-based conception of adolescence that considers all youth as having assets. The volume explores the ways in which developmental assets, when effectively harnessed, empower youth to transition into a productive and resourceful adulthood. The book focuses on PYD across vast geographical regions, including Europe, Asia, Africa, Middle East, Australia, New Zealand, North America, and Latin America as well as on strengths and resources for optimal well-being. The handbook addresses the positive development of young people across various cultural contexts to advance research, policy, and practice and inform interventions that foster continued thriving and reduce the chances of compromised youth development. It presents theoretical perspectives and supporting empirical findings to promote a more comprehensive understanding of PYD from an integrated, multidisciplinary, and multinational perspective.