Anophthalmia

This book provides a comprehensive review on the surgical care of patients requiring removal of an eye, as well as consequent functional and cosmetic rehabilitation. In addition to covering the crafting of ocular prosthetics, Anophthalmia: The Expert's Guide to Medical and Surgical Management also addresses the psychological and physical adjustments to losing an eye, and adapting to that loss. Divided into five parts, Anophthalmia functions as a go-to reference for ophthalmologists and oculoplastic surgeons. The book begins by laying out the clinical foundations and history of anophthalmia. Part II and III discuss surgical removal techniques, prosthesis fitting and maintenance, congenital anophthalmia, infections and inflammations, and newer surgical techniques such as osseointegration after orbital exenteration. Finally, the book concludes with chapters on prosthetic options including scleral shells, keratopigmentation procedures, and cosmetic contact lenses. Unique in content, Anophthalmia is a vital resource for practicing ophthalmologists, oculoplastic surgeons, and all medical professionals who care for patients with surgical and traumatic loss of the eye and orbital tissues. Additionally, sufficient detail and explanation make this work accessible to those in training, such as medical students, ophthalmology residents, and fellows.

This widely acclaimed reference work gives a comprehensive survey of all significant human malformations and related anomalies from the perspective of the clinician. The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly. When known, the molecular or other pathogenetic basis for the malformation is given. Most anomalies are illustrated by photographs or drawings. Specific malformations are linked to syndromes through the extensive use of differential diagnosis tables. Over a decade has passed since the first edition of this book was published, and the revised edition fully incorporates the advances made in the field during the intervening years.. It reflects new understanding of human developmental biology that has emerged from molecular, cytogenetic, and biochemical studies; new observations by clinicians as well as enhanced diagnostic and prevention capacities; and more accurate and comprehensive epidemiology. By condensing much of the information presented in the first volume of the previous edition, and exercising rigorous editorial control, Drs. Stevenson and Hall and their contributors have managed to update the book while reducing its size to that of a single volume. All clinicians and scientists interested in birth defects, including pediatricians, geneticists, genetic counselors, obstetricians, and pediatric pathologists, will find this book to be an invaluable source of information.

This well-illustrated book presents the latest diagnostic concepts and management techniques in the rapidly expanding subspecialty of pediatric oculofacial plastic surgery. Covering all aspects of the field and taking into account numerous surgical innovations and exciting new medical treatment concepts that have emerged since publication of the previous edition in 2002, Pediatric Oculoplastic Surgery, 2nd Edition will prove to be an invaluable resource for both the comprehensive ophthalmologist and the subspecialist with a particular interest in pediatric disorders of the eyelids, orbit, and nasolacrimal system. Topics discussed, in addition to clearly illustrated basic oculoplastic procedures, include surgical innovations ranging from the Sonopet system for safer removal of bone in lacrimal surgery to the development of complex image guidance technology for sinus and orbital surgery. Detailed discussion of syndromic and non-syndromic congenital anomalies explore a variety of surgical techniques and the nuances of applying these approaches in the management of various structural abnormalites. Further important advances include new analytic laboratory techniques, which can illuminate the genetic basis of many pediatric oculoplastic disorders, various medical management advances such as the role of beta blockers in the treatment of facial and orbital hemangiomas, and the development of biologic pathway blockers inhibiting tumor growth which offer real potential for reducing the necessity of surgical intervention.

Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development. The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others. Presents revised and updated information for each chapter on systems Contains expanded sections on applied toxicologic pathology Includes the essential information necessary to understand toxicologic pathology in an accessible language

Consumer health information about the diagnosis and treatment of eye diseases and disorders and the prevention of eye injuries, along with tips for coping with low vision.

A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicologic Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology. This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury. Key Features * Easy to find, up-to-date reference information * Graphic and photographic plates * Current hot topics and anticipated changes in toxicologic pathology * Standardized chapter format * Topics that are addressed in both a broad and deep manner, resulting in a stand alone text * Added coverage of important environmental toxicants * Chapters authored by internationally recognized experts and peer-reviewed

This comprehensive atlas is unique in combining information on the embryological development of the human with detailed presentation of the congenital malformations encountered in clinical practice. As a consequence it will not only assist practitioners and trainees in recognizing and evaluating malformations, but also enable them to understand how a malformation has developed and to explain the mystery of congenital malformations to relatives and patients. The book is organized according to anatomic region, with additional chapters on hernias, tumors, lymphogenesis and lymphatic malformations. According to WHO statistics, each year congenital anomalies result in approximately 3.2 million birth defect-related disabilities worldwide. All too often, however, training in embryology is now a neglected area, and medical graduates frequently lack confidence in their knowledge of the field. Clinical Embryology: An Atlas of Congenital Malformations will help to rectify this deficit and to ensure that malformations are comprehended and managed appropriately. It will be of value for postgraduate trainees in pediatric surgery, pediatrics, and neonatology, undergraduate medical students, and general practitioners/family physicians.

This sixth edition provides an overview of fetal and neonatal pathology through a system-based approach. This book contains new chapters on immunology, with a continued focus on molecular aspects of pathology in the perinatal setting. The general principles of perinatal pathology and their clinical situations are also discussed, along with specific pathological entities and their organ systems. Keeling’s Fetal and Neonatal Pathology, sixth edition aims to help the reader treat common problems through anatomical pathology findings and is relevant to practicing and trainee pathologists, obstetricians, maternal and fetal medicine specialists, neonatologists, and pediatricians.