Antimicrobial Peptides

Antimicrobial Peptides
Author: K. Ajesh,K. Sreejith
Publsiher: Academic Press
Total Pages: 347
Release: 2022-11-23
Genre: Medical
ISBN: 9780323903202

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Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides. Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development. Emphasizes antimicrobial peptides targeting various human viruses and multidrug resistant bacteria Written by internationally recognized experts who provide readers with a wide and useful perspective Provides in-depth resources for undertaking a research work in antimicrobial peptides with the inclusion of chapters on purification techniques and structural details Addresses the possibility and availability of peptide antibiotics in the global drug market Serves as a complete resource from the discovery to drug development of peptide antibiotics

Antimicrobial Peptides

Antimicrobial Peptides
Author: Djamel Drider
Publsiher: Unknown
Total Pages: 0
Release: 2007
Genre: Bioengineering
ISBN: 3805583559

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Antimicrobial peptides, also called host-defense peptides, are an evolutionary conserved component of the innate immune response and are found among all classes of life. This special issue presents a selection of papers comprising reviews, original research articles and short notes from the First International Symposium on Antimicrobial Peptides, held in Nantes in June 2007. It discusses findings from fundamental and applied research, which illustrates future prospects and challenges of antimicrobial peptide science. Topics include the study of resistance mechanisms, the mode of action of antimicrobial peptides and their structure-function relationship. Antimicrobial peptides are promising candidates for novel therapeutic agents, complementing conventional antibiotic therapies to combat pathogenic microorganisms in human and veterinary medicine. Microbiologists, cell and molecular biologists, biochemists as well as infectious disease specialists will find a useful overview of the latest finding in antimicrobial peptide research.

Host Defense Peptides and Their Potential as Therapeutic Agents

Host Defense Peptides and Their Potential as Therapeutic Agents
Author: Richard M. Epand
Publsiher: Springer
Total Pages: 321
Release: 2016-05-06
Genre: Science
ISBN: 9783319329499

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This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this. The chapters, written by leading experts in the field, detail the number and diversity of host defense peptides, and discuss the therapeutic potential not only of antibacterial, but also of antifungal, antiviral, plant antimicrobial and anticancer host defense peptides. The authors provide new insights into their mechanisms of action and their immunomodulatory properties, and review recent advances in the design of novel therapeutic molecules. Lastly, their potential to prevent preterm births and Staphylococcus aureus infections is highlighted. The book is of interest to researchers, industry and clinicians alike.

Natural Products

Natural Products
Author: Moupriya Nag,Dibyajit Lahiri,Jaideep Banerjee,Taniya Roy Chowdhury
Publsiher: CRC Press
Total Pages: 257
Release: 2023-12-01
Genre: Science
ISBN: 9781003801870

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Microbial biofilm plays an important role in the life cycle of microorganisms surviving in diverse and harsh environments such as extremes of temperatures, pH, salinity, nutrient scarcity etc. Biofilm formation is a survival strategy adopted by microorganisms allowing colonization in new niches by dispersal of microbes from the microbial clusters embedded within an outer polymer layer produced by the microorganism itself. This layer comprises of extracellular polymeric substances (EPS) that helps the indwelling microbes to grow and divide in a protected environment against invaders like antimicrobial agents, surfactant, biocides and phagocytic cells of host organisms. Thus, EPS matrix prevents the penetration of antimicrobials thereby allowing the indwelling microbes to survive and give rise to antimicrobial resistance posing threat to human health. The present book highlights a detailed analysis of the mechanism of biofilm formation in both Gram positive and Gram-negative bacteria and the role of quorum sensing signaling mechanism in the genetic regulation pathway. The book titled "Natural Products: Alternative therapeutics as Quorum Sensing (QS) inhibitors" provides a detailed and systematic review of mechanism of quorum sensing in both Gram positive and Gram-negative bacteria and alternative pharmacological developments as a potent solution to the rise of antimicrobial resistance during biofilm formation. Features: A systematic overview of the mechanism of quorum sensing in the development of microbial biofilms Biofilm formation and its role in the emergence of antimicrobial resistance. Recent pharmacological development of antibiofilm remedies involving biogenic compounds. This book serves as a reference book for researchers investigating the progression of events during microbial biofilm formation starting from the genetic cascade regulating quorum sensing to secretion of autoinducers and design of safer methodologies for the successful eradication of microbial biofilm. It may also be used as a textbook for a undergraduate level course in microbiology or microbial biotechnology.

Antimicrobial Peptides

Antimicrobial Peptides
Author: David A. Phoenix,Sarah R. Dennison,Frederick Harris
Publsiher: John Wiley & Sons
Total Pages: 248
Release: 2012-12-27
Genre: Science
ISBN: 9783527652877

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In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers. The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.

Photonanotechnology for Therapeutics and Imaging

Photonanotechnology for Therapeutics and Imaging
Author: Seok Ki Choi
Publsiher: Elsevier
Total Pages: 424
Release: 2020-02-14
Genre: Technology & Engineering
ISBN: 9780128178416

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Photonanotechnology for Therapeutics and Imaging surveys major concepts and recent advances in the use of photonanotechnology with nanomaterials reported in various interdisciplinary fields, including chemistry, materials science, biomedical engineering and biomedicine. This book discusses the impact of this technology on the advancement of therapeutic modalities and imaging methods in cancers, infectious diseases and other serious diseases. Photonanotechnology studies the design principle, application and development of photoactive nanomaterials. It applies light-controlled strategies for the development of nanotherapeutics, imaging agents and diagnostic nanodevices. Provides the latest information on photocontrolled drug delivery systems Details how photoactive nanomaterials are designed to release reactive oxygen species (ROS) for photodynamic therapy (PDT) Explains how photoactive nanomaterials have the ability to induce surface plasmonic heating for photothermal therapeutic (PTT) effects

Peptides as Drugs

Peptides as Drugs
Author: Bernd Groner
Publsiher: John Wiley & Sons
Total Pages: 242
Release: 2009-11-18
Genre: Medical
ISBN: 9783527626847

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By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class. The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs. With its integration of biochemical, pharmaceutical and clinical research, this work reveals the full picture of modern peptide drug research in a single volume, making it an invaluable reference for medicinal chemists, biochemists, biotechnologists, and those in the pharmaceutical and biotechnological industries.

Peptide Applications in Biomedicine Biotechnology and Bioengineering

Peptide Applications in Biomedicine  Biotechnology and Bioengineering
Author: Sotirios Koutsopoulos
Publsiher: Woodhead Publishing
Total Pages: 656
Release: 2017-11-16
Genre: Technology & Engineering
ISBN: 9780081007426

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Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides