Applied Blood Group Serology

Although a few books covering primarily serological aspects of human blood groups are available, it became clear to me in the course of my research that no compendium of the non-serological aspects of human blood group systems exists. This book has been written to facilitate access to the vast number of publications scattered throughout the literature in both chemical and medical journals on the chemistry, biochemistry, and molecular biology of blood groups. It is designed as a concise survey for use by blood bankers and researchers in biochemistry, blood group serology, immunohaemotology, forensic medicine, population genetics, and anthropology; the text is supplemented by numerous illustrations and tables. This volume encompasses the entire field of blood group serology and provides a comprehensive survey of present knowledge in the field. The serological aspects have been kept to a minimum. I have emphasised the chemical, biochemical and molecular genetic basis of blood group specificity and given full consideration to molecular biology investigations, in particular to those on the structure of blood group genes and the structural basis of alleles and rare blood group variants. The book covers the latest developments in research and discusses literature up to the beginning of 1995.

This comprehensive book on transfusion practices and immunohematology offers concise, thorough guidelines on the best ways to screen donors, store blood components, ensure safety, anticipate the potentially adverse affects of blood transfusion, and more. It begins with the basics of genetics and immunology, and then progresses to the technical aspects of blood banking and transfusion. Chapters are divided into sections on: Basic Science Review; Blood Group Serology; Donation, Preparation, and Storage; Pretransfusion Testing; Transfusion Therapy; Clinical Considerations; and Safety, Quality Assurance, and Data Management. Developed specifically for medical technologists, blood bank specialists, and residents, the new edition conforms to the most current standards of the American Association of Blood Banks (AABB). Expert Opinion essays, written by well-known, frequently published experts, discuss interesting topics of research or new advances in the field. Important terms are defined in the margins of the pages on which they appear, enabling readers to easily check the meaning of an unfamiliar term where it appears in context. Margin notes highlight important concepts and points, remind readers of previously discussed topics, offer an alternative perspective, or refer readers to other sources for further information. Material conforms to the most recent AABB standards for the most accurate, up-to-date information on immunohematology. Advanced concepts, beyond what is required for entry-level practice, are set apart from the rest of the text so readers can easily differentiate between basic and advanced information. A new chapter on Hematopoietic Stem Cells and Cellular Therapy (chapter 19) provides cutting-edge coverage of cellular therapy and its relevance to blood-banking. New content has been added on molecular genetics, component therapy, and International Society of Blood Transfusion (ISBT) nomenclature, as well as the latest information on HIV, hepatitis, quality assurance, and information systems. Coverage of new technologies, such as nucleic acid technology and gel technology, keeps readers current with advances in the field.