Ars 91

First multi-year cumulation covers six years: 1965-70.

This book provides critical reviews regarding the process of somatic hypermutation in antibody V genes. Topics covered include the in vivo kinetics of antigen-driven somatic hypermutation in a number of well-studied systems in mice; the instability of lg genes in cultured cells; the key role played in vivo by germinal centers in providing the appropriate "mutational" microenvironment; the types of nucleotide sequence errors generated; the process of hypermutation in pre-arranged V regions expressed in transgenic mice; and a critical evaluation of the status of molecular models proposed to explain hypermutation. Other topics include a detailed review of data from hypervariable retroviral systems, as well as precise studies on the mutagenic potential of various DNA polymerases in vitro. The book will provide indispensable information for immunologists, geneticists, molecular biologists, biochemists, and cell biologists.

February issue includes Appendix entitled Directory of United States Government periodicals and subscription publications; September issue includes List of depository libraries; June and December issues include semiannual index.