Automatic Methods For The Refinement Of System Models

This book provides a comprehensive overview of automatic model refinement, which helps readers close the gap between initial textual specification and its desired implementation. The authors enable readers to follow two “directions” for refinement: Vertical refinement, for adding detail and precision to single description for a given model and Horizontal refinement, which considers several views on one level of abstraction, refining the system specification by dedicated descriptions for structure or behavior. The discussion includes several methods which support designers of electronic systems in this refinement process, including verification methods to check automatically whether a refinement has been conducted as intended.

This book brings together a selection of the best papers from the seventeenth edition of the Forum on specification and Design Languages Conference (FDL), which took place on October 14-16, 2014, in Munich, Germany. FDL is a well-established international forum devoted to dissemination of research results, practical experiences and new ideas in the application of specification, design and verification languages to the design, modeling and verification of integrated circuits, complex hardware/software embedded systems, and mixed-technology systems.

This book constitutes the refereed proceedings of the Joint 21st International Workshop on Formal Methods for Industrial Critical Systems and the 16th International Workshop on Automated Verification of Critical Systems, FMICS-AVoCS 2016, held in Pisa, Italy, in September 2016.The 11 full papers and 4 short papers presented together with one invited talk were carefully reviewed and selected from 24 submissions. They are organized in the following sections: automated verification techniques; model-based system analysis; and applications and case studies.

The aim of the FMICS workshop series is to provide a forum for researchers who are interested in the development and application of formal methods in industry. In particular, these workshops are intended to bring together scientists and practitioners who are active in the area of formal methods and interested in exchanging their experiences in the industrial usage of these methods. These workshopsalso striveto promoteresearchand developmentfor the improvement of formal methods and tools for industrial applications. The topics for which contributions to FMICS 2008 were solicited included, but were not restricted to, the following: – Design, speci?cation, code generation and testing based on formal methods – Veri?cation and validation of complex, distributed, real-time systems and embedded systems – Veri?cation and validation methods that address shortcomings of existing methods with respect to their industrial applicability (e. g. , scalability and usability issues) – Tools for the development of formal design descriptions – Case studies and experience reports on industrial applications of formal methods, focusing on lessons learned or identi?cation of new research - rections – Impact of the adoption of formal methods on the development process and associated costs – Application of formal methods in standardization and industrial forums The workshop included six sessions of regular contributions in the areas of model checking, testing, software veri?cation, real-time performance, and ind- trial case studies. There were also three invited presentations, given by Steven Miller,Rance Cleaveland,and Werner Damm, coveringthe applicationof formal methods in the avionics and automotive industries.

This handbook incorporates new developments in automation. It also presents a widespread and well-structured conglomeration of new emerging application areas, such as medical systems and health, transportation, security and maintenance, service, construction and retail as well as production or logistics. The handbook is not only an ideal resource for automation experts but also for people new to this expanding field.

Macromolecular Crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of accurate molecular structures is a pre-requisite for rational drug design, and for structure-based function studies to aid the development of effective therapeutic agents and drugs. The successful determination of the complete genome (genetic sequence) of several species (including humans) has recently directed scientific attention towards identifying the structure and function of the complete complement of proteins that make up that species; a new and rapidly growing field of study called 'structural genomics'. There are now several important and well-funded global initiatives in operation to identify all of the proteins of key model species. One of the main requirements for these initiatives is a high-throughput crystallization facility to speed-up the protein identification process. The extent to which these technologies have advanced, calls for an updated review of current crystallographic theory and practice. This practical reference book features the latest conventional and high-throughput methods, and includes contributions from a team of internationally recognized leaders and experts. It will be of relevance and use to graduate students, research scientists and professionals currently working in the field of conventional and high-throughput macromolecular crystallography.