Autophagy at the Cell Tissue and Organismal Level

Autophagy at the Cell  Tissue and Organismal Level
Author: Eleftherios Karanasios,Nicholas T. Ktistakis
Publsiher: Springer
Total Pages: 103
Release: 2016-04-23
Genre: Science
ISBN: 9783319331454

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This book provides an expert summary of autophagy, a relatively new but rapidly expanding field of biomedical science with important implications in health and disease. After a historical review ranging up to the identification of autophagy genes in mammals, the authors discuss the signaling pathways that regulate autophagy, the mechanism of autophagosome formation and the physiological roles of autophagy in development, ageing, neurodegeneration, immune function and cell differentiation. A comprehensive list of useful antibodies for studying autophagy compiled as a community effort is included at the end. The book is intended for newcomers to the field, as well as more experienced researchers looking for a condensed but comprehensive introduction to the physiological function and regulation of the autophagic pathway in mammalian organisms.

Autophagy in Health and Disease

Autophagy in Health and Disease
Author: Roberta A. Gottlieb
Publsiher: Academic Press
Total Pages: 240
Release: 2012-12-31
Genre: Science
ISBN: 9780123851024

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Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

Cell Death

Cell Death
Author: Tobias Ntuli
Publsiher: BoD – Books on Demand
Total Pages: 448
Release: 2015-12-16
Genre: Science
ISBN: 9789535122364

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This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Host parasite interactions at the cellular tissue and organism level

Host parasite interactions at the cellular  tissue  and organism level
Author: Xuexian Yang,William Harold Witola,Hua Cong,Huongzhi Chen
Publsiher: Frontiers Media SA
Total Pages: 144
Release: 2024-05-31
Genre: Medical
ISBN: 9782832549735

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Protozoan and helminth parasites infect animals and humans and cause debilitating pathologies that cause a variety of morbidities and deaths worldwide. The ability of parasites to establish infection and cause disease in mammalian hosts is a result of a series of intricate mechanisms evolved by parasitic species to confront and evade the host's defensive responses, along with the ability to use the host’s metabolic and catabolic processes and host cellular organelles to their benefit. For instance, parasites may have predilection sites in the host that are not accessible to immune effector molecules and mechanisms, may acquire host-derived "masking" molecules, can vary their surface molecules, and can produce molecules that block or misguide the host immune responses. The host's interactions with the parasite, on the other hand, are critical for the initiation and induction of host signaling events that are critical in mounting formidable defensive immune responses against the invading parasite. Therefore, the ability of a parasite to successfully establish infection and cause disease largely depends on its interaction with the host and the ability of the host to mount successful and effective resistance. Thus, studying host-parasite interactions and cross-talks is critical for understanding parasite infection and adaptation mechanisms within the host, as well as for developing strategies for effective prevention and control of parasitic infections in humans and animals. The topic will cover a wide spectrum of parasitic protozoa and helminths and provide an opportunity to share new molecular and translational advances in parasitic infections and diseases.

Integrative Neurology

Integrative Neurology
Author: John W. McBurney,Andrew T. Weil,Ilene S. Ruhoy
Publsiher: Oxford University Press, USA
Total Pages: 529
Release: 2020
Genre: Health & Fitness
ISBN: 9780190051617

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"Neurology is a quantitively small corner of medicine that, increasingly, occupies a position of outsized importance and distinction in both the practice of medicine and in the health and well-being of society. The Decade of the Brain came into public awareness in 1990 as an initiative of president George W. Bush involving the NIH and NIMH "to enhance public awareness of the benefits to be derived from brain research"(1). In the intervening 20 years since 1999, we have seen significant increases in understanding the myriad of neurological diseases that confront society"--

Autophagy and Signaling

Autophagy and Signaling
Author: Taylor & Francis Group
Publsiher: CRC Press
Total Pages: 268
Release: 2021-03-30
Genre: Electronic Book
ISBN: 0367657724

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Autophagy and Signaling is an up-to-date overview of the many signaling pathways regulating autophagy in response to different cellular needs. Discussion includes the status and future directions of autophagy signaling research with respect to different aspects of health and disease. These include the roles of autophagy in regulating cell fate, immune response and host defense, nutrient sensing and metabolism, neural functions and homeostasis. The mechanisms and significance of cross-talk between autophagy and other cellular processes is also explored. Lastly, alterations in autophagy observed in aging and age-related pathologies are described.

Autophagy in Health and Disease

Autophagy in Health and Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 446
Release: 2020-06-30
Genre: Science
ISBN: 9780128220221

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Autophagy in Health and Disease, Volume 175, presents the latest insights from renowned experts in the field who discuss the key role of autophagic responses in the preservation of cellular and organismal homeostasis and how defects in the molecular apparatus for autophagy drive or accompany disease. Specific chapters in this new release include Crosstalk between autophagy and cell death signaling: mechanisms and therapeutic relevance, C. elegans to model autophagy-related human disorders, Autophagy in Kidney Disease: advances and therapeutic potential, Autophagy in Chronic Lung Disease, Autophagy in motoneuronal disorders, Strategies employed by viruses to manipulate autophagy, and much more. Provides an outstanding panel of recognized experts in the field who discuss the latest in autophagy Includes critical discussions of autophagy in the context of each major human disorder Models autophagy-related human pathologies in lower eukaryotes

Autophagy and Cancer

Autophagy and Cancer
Author: Hong-Gang Wang
Publsiher: Springer Science & Business Media
Total Pages: 267
Release: 2013-03-30
Genre: Medical
ISBN: 9781461465614

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With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it. ​