Biodegradable Polymers In Pharmacy And Medicine Classification Chemical Structure Principles Of Biodegradation And Use

Document from the year 2016 in the subject Medicine - Pharmacology, , course: Pharmaceutical technology, language: English, abstract: The aim of this book is to provide a brief but comprehensive overview on the issue of biodegradable polymers. The introduction chapter is followed by a description of the general characteristics of biodegradable polymers and pathways of their degradation in the human body. Particular pitfalls and specifics of their various biomedical and pharmaceutical applications, especially in the field of pharmaceutical technology, are described in order to define the ideal carrier polymer system for specific types of therapy. Finally, the work presents the classification of these polymers based on the type of degradation mechanism. This section also includes the chemical structure of particular polymer molecules, their chemical or bio-synthesis and the description of their uses in specific biomedical and pharmaceutical applications. The book could be used as a textbook for students of medical and pharmaceutical sciences as well as by researchers in this field or industrial area. In the past few decades, biodegradable polymers have reached significant importance in fields of biomedical and pharmaceutical applications. They have become preferred candidates for the manufacture of therapeutic forms, for instance, orthopaedics devices, temporary bone screws and spins, three-dimensional scaffolds for tissue engineering or drug delivery systems for sustained and targeted release. Each of these applications requires material with specific physical, biological, and chemical properties, as well as specific degradation profile. These polymers (natural or synthetic) undergo hydrolytic or enzymatic degradation, which both have some advantages and disadvantages. Most widely used polymer materials in biomedical applications are listed, including their structure and degradation pathways.

The emphasis in degradable polymers has changed since the first edition of this book. Biomedical and agricultural applications remain important topics of scientific and commercial interest in the second edition. However, an increased emphasis on composting as a means of recovering value from wastes has led to a new impetus to understand how plastics degrade in the environment and the implication of this for international standards. Polymers based on renewable resources are also a major topic in this edition but the debate continues about their long-term sustainability and ecological advantages over degradable man-made polymers. Degradable Polymers will be of interest not only to academic and industrial scientists working on packaging, agricultural and medical applications of plastics but also to students of environmental science and legislators concerned with the effects of man-made materials in the environment.

This book focuses on biodegradable polymers that are already in clinical use or under clinical development. Synthetic and natural polymers will be included. This excludes polymers that have been investigated and did not reach clinical development. The purpose of this book is to provide updated status of the polymers that are clinical use and those that are now being developed for clinical use and hopefully will reach the clinic during the next 5 years. The book provides information that of interest to academics and practicing researchers including chemists, biologists and bioengineers and users: physicians, pharmacists.

Handbook of Biodegradable Polymers, the seventh volume in the Drug Delivery and Targeting book series, provides a source manual for synthetic procedures, properties and applications of bioerodible polymers. The authors describe widely available materials such as polyactides, collagen and gelatin, as well as polymers of emerging importance, such as the genetically-engineered and elastin-based polymers which are either proprietary or in early stages of development. Section I addresses synthetic absorbable polymers, and Section 2 profiles natural, semi-synthetic and biosynthetic polymers. Section 3 discusses the surface characterization of degradable polymers, the modeling of biodegradation and non-medical polymers. This book is ideal for researchers from academia and industry as well as chemists, pharmacists and physicians who deal with biopolymers, drug delivery and targeting, bioengineering and implantable devices.

Biodegradable plastics made with plant based materials have been available for many years. The term biodegradable means that a substance is able to be broken down into simpler substances by the activities of living organisms, and therefore is unlikely to persist in the environment. There are many different standards used to measure biodegradability, with each country having its own. The requirements range from 90 per cent to 60 per cent decomposition of the product within 60 to 180 days of being placed in a standard composting environment. They may be composed of either bio plastics, which are plastics whose components are derived from renewable raw materials, or petroleum based plastics which contain additives. Biodegradability of plastics is dependent on the chemical structure of the material and on constitution of the final product, not just on the raw materials used for its production. Polyesters play a predominant role as biodegradable plastics due to their potentially hydrolysable ester bonds. Bio based polymers are divided into three categories based on their origin and production; polymer directly extracted from biomass, polymers produced by classical chemical synthesis using renewable biomass monomer and polymers produces by microorganisms or genetically modified bacteria. In response to public concern about the effects of plastics on the environment and in particular the damaging effects of sea litter on animals and birds, legislation is being enacted or is pending in many countries to ban non degradable packing, finishing nets etc. This book basically deals with biodegradable plastics developments and environmental impacts, hydro biodegradable and photo biodegradable, starch synthetic aliphatic polyester blends, difference between standards for biodegradation, polybutylene succinate (pbs) and polybutylene, recent developments in the biopolymer industry, recent advances in synthesis of biopolymers by traditional methodologies, polymers, environmentally degradable synthetic biodegradable polymers as medical devices, polymers produced from classical chemical synthesis from bio based monomers, potential bio based packaging materials, conventional packaging materials, environmental impact of bio based materials: biodegradability and compostability, etc. Environmentally acceptable degradable polymers have been defined as polymers that degrade in the environment by several mechanisms and culminate in complete biodegradation so that no residue remains in the environment. The present book gives thorough information to biodegradable plastic and polymers. This is an excellent book for scientists engineers, students and industrial researchers in the field of bio based materials. 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This book contains a collection of different biodegradation research activities where biological processes take place. The book has two main sections: A) Polymers and Surfactants Biodegradation and B) Biodegradation: Microbial Behaviour.

Biopolymer Composites in Electronics examines the current state-of-the-art in the electronic application based on biopolymer composites. Covering the synthesis, dispersion of fillers, characterization and fabrication of the composite materials, the book will help materials scientists and engineers address the challenges posed by the increased use of biopolymeric materials in electronic applications. The influence of preparation techniques on the generation of micro, meso, and nanoscale fillers, and the effect of filler size and dispersion on various biopolymers are discussed in detail. Applications covered include sensors, actuators, optics, fuel cells, photovoltaics, dielectrics, electromagnetic shielding, piezoelectrics, flexible displays, and microwave absorbers. In addition, characterization techniques are discussed and compared, enabling scientists and engineers to make the correct choice of technique. This book is a ‘one-stop’ reference for researchers, covering the entire state-of-the-art in biopolymer electronics. Written by a collection of expert worldwide contributors from industry, academia, government, and private research institutions, it is an outstanding reference for researchers in the field of biopolymer composites for advanced technologies. Enables researchers to keep up with the rapid development of biopolymer electronics, which offer light, flexible, and more cost-effective alternatives to conventional materials of solar cells, light-emitting diodes, and transistors Includes thorough coverage of the physics and chemistry behind biopolymer composites, helping readers to become rapidly acquainted with the fiel Provides in-depth information on the range of biopolymer applications in electronics, from printed flexible conductors and novel semiconductor components, to intelligent labels, large area displays, and solar panels

Synthetic and semi-synthetic polymeric materials were originally developed for their durability and resistance to all forms of degradation including biodegradation. Such materials are currently widely accepted because of their ease of processability and amenability to provide a large variety of cost effective items that help to enhance the comfort and quality of life in the modern industrial society. However, this widespread utilization of plastics has contributed to a serious plastic waste burden, and the expectation for the 21st century is for an increased demand for polymeric material. This volume focuses on a more rational utilization of resources in the fabrication, consumption and disposal of plastic items, specifically: -Environmentally Degradable Polymeric Materials (EDPs); -Water-soluble/Swellable Biodegradable Polymers; -EDPs from Renewable Resources; -Biopolymers; -Bioresorbable Materials for Biomedical Applications; -Biorelated Polymers; -Standards and Regulations on EDPs.