Bone Morphogenetic Proteins

Completing the PIR series, this volume summarizes the major advances made in the local and systemic use of bone morphogenetic proteins (BMPs). Chapters are dedicated to the regulation of BMP-signaling pathways; biological actions of BMPs in bone, cartilage, and teeth; clinical applications; and the potential systemic use of BMPs for tissues beyond bone. The authors are all recognized experts in the field of tissue engineering and regeneration.

From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of scientific topics, including biochemistry, biology, molecular biology and preclinical animal studies on spinal fusion, cartilage repair, craniofacial and dental reconstruction using BMPs, as well as approved clinical applications in human bone non-unions. This book provides a resource not only for experts in the field, but also for undergraduate students, newcomers and clinicians worldwide, given that the use of BMPs in orthopedic reconstruction has been already approved in Europe, Australia, Canada and the USA.

Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. The potent effica cy of BMPs in almost all crucial developmental events as well as during regenera tion of various organs such as bone, kidney, brain, liver, heart etc. , has positioned BMPs at the center of scientific interest. Many of these aspects are covered in this new PIR volume. Their role in development, biology, signal transduction, kidney regeneration, eNS functions, craniofacial skeleton reconstruction, joint and carti lage repair, long bone non-unions and acute fractures, and spinal fusion is reviewed by experts in the field. For the first time, the role of BMPs in carcinogenesis has been reviewed to provide a rationale for applying their biology in patients with bone tumors. The optimism resulting from safe and successful treatment with BMPs for various skeletal malformations of more than 10,000 patients worldwide has opened new avenues for exploring other indications for their use. The next big challenge for bringing BMPs to the benefit ofmankind is in regenerating articular cartilage defects and rescuing patients with acute and chronic renal failure. The volume editors thank all authors for the rapid preparation of their chapters in order that the book remains up-to-date for readers with specific interest in the field of regenerative medicine. The important contribution of Mrs. Morana and Mr.

This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.

Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Bone Morphogenetic Proteins in a concise format. The editors have built Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bone Morphogenetic Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on Bone Morphogenic Protein. Expertise of the contributors Coverage of a vast array of subjects In depth current information at the molecular to the clinical levels

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition