Brain Iron Metabolism And Cns Diseases
Download Brain Iron Metabolism And Cns Diseases full books in PDF, epub, and Kindle. Read online free Brain Iron Metabolism And Cns Diseases ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Brain Iron Metabolism and CNS Diseases
Author | : Yan-Zhong Chang |
Publsiher | : Unknown |
Total Pages | : 135 |
Release | : 2019 |
Genre | : Central nervous system |
ISBN | : 981139590X |
Download Brain Iron Metabolism and CNS Diseases Book in PDF, Epub and Kindle
This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.
Iron in Central Nervous System Disorders
Author | : Peter Riederer,M.B.H. Youdim |
Publsiher | : Springer Science & Business Media |
Total Pages | : 277 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9783709193228 |
Download Iron in Central Nervous System Disorders Book in PDF, Epub and Kindle
The role of the metals copper, zinc, magnesium, lead, manganese, mercury, lithium and aluminium in neuropsychiatric disease are well known and has been discussed on several occasions. Yet little attention has been paid to iron, the most abundant transitional metal in the body and the earth's crust. Iron plays a major role as a cofactor of numerous metabolic enzymes, it is important for DNA and protein synthesis, and has a crucial role in the oxygen carrying capacity of haemoglobin. Some of the most devastating diseases of systemic organs are associated with abnormal iron metabolism. Yet only very recently its role in the central nervous system has been considered. Thus nutritional iron defi ciency and iron overload afflict some 500-600 million people. It is also well recognized that too little or too much iron can produce profound effects on the metabolic state of the cell, and therefore the regulation of iron uptake and disposition is tightly relegated by the cell. Its transport into the cell and storage are handled by transferrin, ferritin and haemo siderin. Nowhere are these processes so well recognized as in the case of brain iron metabolism. Iron does not have ready access to the adult brain as it does to other tissues, since it does not cross the blood brain barrier (BBB). All the iron present in brain is deposited before the closure of BBB at an early age where it is sequestered and conserved. Therefore its turnover is extremely slow.
Brain Iron Metabolism and CNS Diseases
Author | : Yan-Zhong Chang |
Publsiher | : Springer Nature |
Total Pages | : 194 |
Release | : 2019-08-27 |
Genre | : Medical |
ISBN | : 9789811395895 |
Download Brain Iron Metabolism and CNS Diseases Book in PDF, Epub and Kindle
This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.
Brain Iron Cross Talk
Author | : Wael Mohamed,Nicola Luigi Brogazzi,Richard M. Kostrzewa |
Publsiher | : Springer Nature |
Total Pages | : 289 |
Release | : 2022-12-16 |
Genre | : Medical |
ISBN | : 9789811973277 |
Download Brain Iron Cross Talk Book in PDF, Epub and Kindle
This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It presents the effect of iron dysregulation on neurophysiological mechanisms. The book provides an overview of iron metabolism and homeostasis at the cellular level and its regulation at the mRNA translation level. It emphasizes the importance of iron for brain development in fetal and early life in preterm infants. Further, it presents iron metabolism as a therapeutic target for novel pharmacological treatment against neurodevelopmental diseases and neurodegenerative disorders. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases. Finally, it relates dysregulated expression of iron-related genes in brain tumors.
Iron in Central Nervous System Disorders
![Iron in Central Nervous System Disorders](https://youbookinc.com/wp-content/uploads/2024/06/cover.jpg)
Author | : Peter Riederer,Moussa B. H. Youdim |
Publsiher | : Springer Verlag |
Total Pages | : 205 |
Release | : 1993-01-01 |
Genre | : Medical |
ISBN | : 0387825207 |
Download Iron in Central Nervous System Disorders Book in PDF, Epub and Kindle
Iron and Neurodegeneration
Author | : Isabella Zanella,Massimiliano Filosto,Giorgio Biasiotto |
Publsiher | : Frontiers Media SA |
Total Pages | : 369 |
Release | : 2020-01-23 |
Genre | : Electronic Book |
ISBN | : 9782889634514 |
Download Iron and Neurodegeneration Book in PDF, Epub and Kindle
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Iron Metabolism Redox Balance and Neurological Diseases
Author | : Yan-Zhong Chang |
Publsiher | : Mdpi AG |
Total Pages | : 0 |
Release | : 2023-11-21 |
Genre | : Science |
ISBN | : 3036588442 |
Download Iron Metabolism Redox Balance and Neurological Diseases Book in PDF, Epub and Kindle
With the aging of the population, the incidence rate and number of elderly nervous system diseases have increased sharply. This event has brought huge problems to society. Despite significant efforts being made to explore new treatment options and drugs, the results have been limited. The reason may be due to people's incomplete understanding of the pathogenesis of these age-related diseases. Iron is the most abundant trace element in the human body and is essential for normal life activities. Previous studies have shown that brain iron levels increase with age. The abnormal increase in brain iron levels is closely related to age-related neurological diseases. The disruption of the redox balance may be an important mechanism for the occurrence of neurological diseases caused by brain iron abnormalities. This Special Issue mainly highlights and discusses the latest research progress related to the regulation of brain iron metabolism, redox balance, and the pathogenesis of neurological diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), cerebral ischemia, cancer and maintenance of cellular stemness. The molecular mechanisms of iron-misregulation-induced redox imbalance in disease pathogenesis were analyzed. On this basis, further discussions were conducted on potential therapeutic targets for regulating iron metabolism to achieve effective intervention in elderly neurological diseases.
Iron Deficiency and Overload
Author | : Shlomo Yehuda,David I. Mostofsky |
Publsiher | : Springer Science & Business Media |
Total Pages | : 377 |
Release | : 2010-03-10 |
Genre | : Medical |
ISBN | : 9781597454629 |
Download Iron Deficiency and Overload Book in PDF, Epub and Kindle
Iron deficiency is ever-present among all populations throughout the world irrespective of race, culture, or ethnic background. Even with the latest advances in medicine, improved nutrition, and the ready availability of cheap oral iron, there is still no satisfactory explanation for the widespread occurrence of iron deficiency or for the absence of an effective treatment. Iron Deficiency and Overload: From Biology to Clinical Medicine is an important new text that provides a timely review of the latest science concerning iron metabolism as well as practical, data-driven options to manage at-risk populations with the best accepted therapeutic nutritional interventions. Chapter topics reflect the excitement in current theoretical development and laboratory activity in this area. The distinguished authors address their presentations to professionals and graduate students who need to be better informed about the concepts, methodologies, and current status of the field. Iron Deficiency and Overload: From Biology to Clinical Medicine is an essential text that presents a sampling of the major issues in iron research, from the most basic research level to human applications.