Brain Stimulation And Motivation

This book was conceived many years ago as an abstract goal for a father-son team when the father was working in university administration and the son was just getting into the academic business. Eventually, the father returned to the laboratory, the son began to get his feet on the ground, and the goal became concrete. Now the work is finished, and our book enters the literature as, we hope, a valuable contribution to understanding the terribly complex and subtle problem of the neuro biology of motivated behaviors. We would also like the book to stand as a personal mark of a cooperative relationship between father and son. This special relationship between the authors gave us an extra dimension of pleasure in writing the book, and it would delight us if it gave anyone else an extra dimension of enjoyment from reading it. One thing we hope happens is that anyone or simply considering entering similar considering a similar partnership, of this book as encouragement. Such re fields, will take the existence lationships are highly satisfying if both parties take care to protect the partnership. When we actually sat down to write the book, we were humbled by the immense literature and the smallness of both our conceived space for putting it down and of our brains for processing all the information.

To scientists engaged in research on the cellular mechanisms in the mammalian brain, concepts of "motivation" seem to be a logical neces sity, even if they are not fashionable. Immersed in the detailed, time consuming research required to deal with mammalian nerve cells, we usually pay scant attention to the more global brain -behavior questions that have arisen from decades of biological and psychological studies. We felt it was time to confront these issues-namely, how far has neuro biological investigation come in uncovering mechanisms by which moti vational signals influence behavior? At Rockefeller University, we have recently held a course on this subject. We restricted our treatment to those motivational systems most tractable to physiological approaches, and invited scientists skilled in both behavioral issues and physiological techniques to participate. This volume results from that course. The deans and administration at Rockefeller University provided much help in planning the course, and the staff of Springer-Verlag assisted in planning the book. Gabriele Zummer helped organize both the course and the processing of book chapters. They all deserve our thanks. December 1981 Donald W. Pfaff Professor of Neurobiology and Behavior Rockefeller University Contents Part One: Concepts. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Chapter 1 Donald W. Pfaff Motivational Concepts: Definitions and Distinctions . . . . . . . . . . 3 Motivation: A Brief Review of Concepts. . . . . . . . . . . . . . . . . . . . . . . . . . 5 Drive . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Reinforcement, Reward . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Incentive . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Arousal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Emotion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Motivation Is a Unitary Behavioral Concept with Multiple Neurophysiological Mechanisms. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 Chapter 2 Alan N.

Neal E. Miller's pioneering work in experimental psychology has earned him worldwide respect. This second in a two-volume collection of his work brings together forty-three of Miller's most important and representative essays on learning, motivation, and their physiological mechanisms. They were selected on the basis of their current relevance and their historical significance at the time they were published. In order to emphasize the main themes, essays on a given topic have been grouped together.Learning, Motivation, and Their Physiological Mechanisms begins when the author first discovered the thrill of designing and executing experiments to get clear-cut answers concerning the behavior of children and of rats. The first study was one of the earliest ones on the behavioral effects of the recently synthesized male hormone, testosterone. The second was one of the earliest studies demonstrating the value of using a variety of behavioral techniques to investigate the motivational effects of a physiological intervention. The next studies investigated the satisfying and rewarding effects of food or water in the stomach versus in the mouth and the thirst-inducing and reducing effects of hyper- and hypotonic solutions, respectively, injected into the brain. The last study describes a technique devised for extending the analysis of the mechanism of hunger to the effects of humoral factors in the blood.The study is completed with an examination of trial-and-error learning that was motivated by direct electrical stimulation of the brain and rewarded by the termination of such stimulation. Other studies show that the stimulation via such electrodes not only elicits eating, but also has the principal motivational characteristics of normal hunger. The conclusion deals with a series of experiments that overthrows strong traditional beliefs by proving that glandular and visceral responses mediated by the autonomic nervous system are subject to instrumental learning, which can be

Brain stimulation technologies are both tools to probe brain function and to provide therapeutic options for patients with neuropsychiatric disease where pharmacological options are not viable. Although the field has been in existence for over seventy years, research interest in brain stimulation has been on the rise particularly in the last two decades. Brain Stimulation: Methodologies and Interventions is an introduction to the field of brain stimulation technology and its applications. The book explores how brainstimulating technologies work in the context of brain pathways that mediate normal and abnormal brain function. Chapters cover neuroanatomy and activity dependent changes in neuronal function triggered by brain stimulation, as well as applications of brain stimulation technologies themselves, including noninvasive procedures that rely on convulsive or seizure therapeutics, and non-convulsive therapies such as magnetic and electrical brain stimulation. Authored by an international group of leaders in the field, Brain Stimulation is a valuable resource for both neuroscience researchers and clinicians.

Some of our time is spent eating and drinking and some is spent on matters regarding reproduction. Some of us seek fame or recognition while others seek satisfaction internally, with little need for recognition. Some people study for success in a profession, while others might study rocks, birds, or French literature for no apparent reason other than to know about it. Why are we motivated to engage in so many apparently unrelated activities? This book places our various activities into categories, thus providing a framework for understanding how everything that we do fits together and is based on brain mechanisms. Disturbances in motivation play important roles in autism, depression, Parkinson's disease, and addiction. Understanding the motivational aspects of these disorders can help to inform our approach to these conditions. This book may be of value for students in psychology, counseling, management, and anyone who is interested in understanding our daily behavior.