Catalytic Transformations Via C H Activation

The reference work Science of Synthesis: Catalytic Transformations via C-H Activation covers the state of the art in C-H activation chemistry. Experts in the field present the best synthetic methods including typical or general experimental procedures. As such, this two volume set can serve as both a basis for the practical application of the techniques discussed, and as an educational resource to lay the foundations for future research. Volume 1 concerns the formation of C-C bonds by both arene and hetarene C-H activation. For the arenes the material is subdivided into arylation (using palladium(0), palladium(II)/palladium(IV), palladium(II), and ruthenium(II) catalysts), vinylation (using various palladium and ruthenium(III) catalysts), and alkylation (using various metal catalysts in combination with either functionalized alkanes or alkenes). For the hetarenes, the related coupling strategies are covered as a single topic using a variety of metal catalysts and coupling partners.

The reference work Science of Synthesis: Catalytic Transformations via C-H Activation covers the state of the art in C-H activation chemistry. Experts in the field present the best synthetic methods including typical or general experimental procedures. As such, this two volume set can serve as both a basis for the practical application of the techniques discussed, and as an educational resource to lay the foundations for future research. Volume 1 concerns the formation of C-C bonds by both arene and hetarene C-H activation. For the arenes the material is subdivided into arylation (using palladium(0), palladium(II)/palladium(IV), palladium(II), and ruthenium(II) catalysts), vinylation (using various palladium and ruthenium(III) catalysts), and alkylation (using various metal catalysts in combination with either functionalized alkanes or alkenes). For the hetarenes, the related coupling strategies are covered as a single topic using a variety of metal catalysts and coupling partners.

The reference work "Science of Synthesis: Catalytic Transformations via C-H Activation" covers the state of the art in C-H activation chemistry. Experts in the field present the best synthetic methods including typical or general experimental procedures. As such, this two volume set can serve as both a basis for the practical application of the techniques discussed, and as an educational resource to lay the foundations for future research. Volume 2 concerns the formation of C-C bonds by C-H activation of non-(het)arene substrates as well as C-H activation using special reagents or techniques. The formation of C-heteroatom bonds by predominantly arene C-H activation is also reviewed. For C-C bond formation, the material is subdivided into allylic, alkyl, and double C-H activation techniques, coupling using carbenes or radicals, and carbonylation or carboxylation processes.

Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.

Over the past decade, much research effort has been devoted to the design and synthesis of new reagents and catalysts that can influence carbon-hydrogen bond activation, mainly because of the prospect that C−H activation could enable the conversion of cheap and abundant alkanes into valuable functionalized organic compounds. Alkane C-H Activation by Single-Site Metal Catalysis presents the current state-of-the-art development in the catalytic systems for the catalytic trans-formations of alkanes under homogeneous conditions. Chapter 1 offers a comprehensive summary of the main discoveries realized so far. Chapter 2 reviews the so-called electrophilic activation, initiated by Shulpín in the late 60s, and the base for the Catalytica system. Chapter 3 examines the catalytic borylation of alkanes, discovered by Hartwig, whereas chapter 4 provides an updated vision of the alkane dehydrogenation reaction. Chapter 5 covers the oxygenation of C-H bonds, a field of enormous interest with bioinorganic im-plications, and finally chapter 6 presents the functionalization of alkane C-H bonds by carbene or nitrene insertion. The history of C-H bond activation, and the current research described in this book, highlight the current research and present the reader with an outlook of this field which continues to be explored by an increasingly visionary and enthusiastic group of organic, organometallic, biological and physical chemists.