Checkpoints

Written specifically for the teen, this book explains the seven principles teens need to know to be victorious in their faith.

This book maps the risk points that are emerging for cross-border corporate transactions in the digital and Internet eras and in the new enforcement environment, and explains the best practices to avert liability in cross-border transactions.

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.

The Seven Checkpoints for Student Leaders is more than a book; it is a ministry plan. It goes far beyond the "how to" of youth ministry and provides youth ministers, youth works, and parents with the content that students need to equip them for 'life beyond youth group." The material in this book and the companion book The Seven Checkpoints Student Journal reveals what Stanley calls "the irreducible minimum"--the essential principles upon which an entire youth ministry can be built. Stanley and Hall offer some unorthodox but very sensible approaches to planning and maintaining a youth group over a long period of time with a specific goal in mind. The book outlines a strategy for effectively teaching students over the course of their time in school, and this new updated edition is what every leader needs to keep up with the ever-changing challenges students face. Stanley and Hall identify seven "checkpoints" that are the most important and critical issues facing teens: 1. Authentic Faith 2. Spiritual Disciplines 3. Moral Boundaries (this section deals primarily with issues of sexual purity and dating) 4. Healthy Friendships 5. Wise Choices 6. Ultimate Authority 7. Others First Practical application, biblical principles, and realistic approaches for facing modern challenges facilitate teaching for busy youth leaders that will make an impact for eternity.

Immunotherapy based on immune checkpoint molecules is gradually becoming an important treatment strategy for gastrointestinal tumours and inflammation. This Research Topic will focus on the role of immune checkpoint molecules in gastrointestinal inflammation and tumours, the latest progress in the corresponding regulatory mechanisms. Meanwhile, this topic explores the similarities and differences of different immune checkpoint molecules in tumours such as gastric cancer and colorectal cancer and inflammatory diseases such as inflammatory bowel diseases, intestinal-related sepsis, and peritoneal infection. Furthermore, not only limited to oncology treatment, the application of immune checkpoint inhibitors extends to inflammatory diseases of the gastrointestinal tract. Thus, immunotherapy targeting immune checkpoint molecules offers great promise for the treatment of gastrointestinal disorders. Immunotherapy is one of the most cutting-edge fields in the current treatment of gastrointestinal diseases. Immune checkpoint inhibitors have been gradually applied in the clinical treatment of gastrointestinal tumours and have been gradually explored in gastrointestinal inflammatory diseases. However, whether the expression of different immune checkpoint molecules affects the selection of immune checkpoint molecular inhibitors, how to combine different immune checkpoint molecular inhibitors, and how to screen outpatients responsive to immune checkpoint molecular inhibitors in urgent scientific questions to be addressed.