Chromosomal Nonhistone Protein

The fourth and last volume of Chromosomal Nonhistone Proteins sequence attempts to confront these macromolecules with the major structural elements of the cell nucleus (with the exception of nucleosomes which will be treated separately in a later treatise). Proteins of the chromosomes, nucleoli, nuclear membrane, RNP particles, and nuclear matrix are described in detail.

The second volume of the Chromosomal Nonhistone Proteins treatise is dedicated in its entirety to the immunobiology of these proteins. Since immunological methods are adding rapidly to our knowledge of the specificity and intranuclear localization of chromosomal nonhistone proteins, a collection of chapters dealing with various aspects of this important area was judged appropriate.

The first volume of the Chromosomal Nonhistone Proteins treatise presents a summary of the many attempts in the literature to correlate changes in chromosomal histone proteins specificity and metabolism with transcriptional regulations in eukaryotic cells.

The third volume of the Chromosomal Nonhistone Proteins treatise deals with the isolation and analysis of chromosomal proteins in general with specific features of these proteins in particular. In addition to the high mobility group (HMG) proteins, post synthetic modifications of chromosomal nonhistone proteins are discussed, together with some of their enzymatic properties DNA binding.

As a follow-up to Volumes I and II in this series, in this volume the authors attempt to provide an update into the current research in NHCP with the hope that these articles may foster a more analytical elucidation of the role of these proteins in gene expression.