Clinical Chemistry Of Laboratory Animals Second Edition

Millions of individual clinical chemistry determinations are performed annual on specimens from rats, mice, and other lab species in the course of biomedi studies. Information obtained is used in a plethora of journal publications agency reports. The objective here is to make this data readily avail.

Key features: Serves as the detailed, authoritative source of the clinical chemistry of the most commonly used laboratory animals Includes detailed chapters dedicated to descriptions of clinical chemistry-related topics specific to each laboratory species as well as organ/class-specific chapters Presents information regarding evaluation and interpretation of a variety of individual clinical chemistry end points Concludes with detailed chapters dedicated to descriptions of statistical analyses and biomarker development of clinical chemistry-related topics Provides extensive reference lists at the end of each chapter to facilitate further study Extensively updated and expanded since the publication of Walter F. Loeb and Fred W. Quimby’s second edition in 1999, the new The Clinical Chemistry of Laboratory Animals, Third Edition continues as the most comprehensive reference on in vivo animal studies. By organizing the book into species- and organ/class-specific chapters, this book provides information to enable a conceptual understanding of clinical chemistry across laboratory species as well as information on evaluation and interpretation of clinical chemistry data relevant to specific organ systems. Now sponsored by the American College of Laboratory Animal Medicine (ACLAM), this well-respected resource includes chapters on multiple laboratory species and provides pertinent information on their unique physiological characteristics, methods for sample collection, and preanalytical sources of variation for the particular species. Basic methodology for common procedures for each species is also discussed. New Chapters in the Third Edition Include: The Laboratory Zebrafish and Other Fishes Evaluation of Cardiovascular and Pulmonary Function and Injury Evaluation of Skeletal Muscle Function and Injury Evaluation of Bone Function and Injury Vitamins Development of Biomarkers Statistical Methods The Clinical Chemistry of Laboratory Animals, Third Edition is intended as a reference for use by veterinary students, clinical veterinarians, verterinary toxicologists, veterinary clinical pathologists, and laboratory animal veterinarians to aid in study design, collection of samples, and interpretation of clinical chemistry data for laboratory species.

By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and thyroid), the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science.

By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and

Clinical Laboratory Animal Medicine: An Introduction, Fourth Edition offers a user-friendly guide to the unique anatomy and physiology, care, common diseases, and treatment of small mammals and nonhuman primates. Carefully designed for ease of use, the book includes tip boxes, images, and review questions to aid in comprehension and learning. The Fourth Edition adds new information on transgenic mice, drug dosages, techniques, and environmental enrichment, making the book a comprehensive working manual for the care and maintenance of common laboratory animals. The book includes information on topics ranging from genetics and behavior to husbandry and techniques in mice, rats, gerbils, hamsters, guinea pigs, chinchillas, rabbits, ferrets, and nonhuman primates. A companion website provides editable review questions and answers, instructional PowerPoints, and additional images not found in the book. Clinical Laboratory Animal Medicine is an invaluable resource for practicing veterinarians, veterinary students, veterinary technicians, and research scientists.

Laboratory animals, including rabbits, play an important role in biomedical research and advances. The humane care and management of these animals is an ongoing concern. This guide was created especially for individuals performing research with rabbits whose duties include animal facility management, animal husbandry, regulatory compliance, and technical procedures involved with their research. Basic information and common procedures are presented in detail.

10+ Years of Updates Since First Edition Newcomers to the animal clinical chemistry and toxicology fields quickly find that the same rules of human medicine do not always apply. Following in the footsteps of its standard-setting first edition, Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition collates information widely dispersed in journals and book chapters, focusing on the most relevant literature to experimental toxicology and its distinction from human medicine. Expands Discussion of Troponins, Lipids, and Electrolytes In addition to tests recommended by regulatory authorities, this globally relevant resource includes information about clinical chemistry tests as well as hepato-, nephro-, cardio-, and endocrine toxicity. It also covers pre-analytical and analytical variables, which play a far more important role with interpreting data from animal studies as compared to human studies when variables can be well controlled with less physiological effect. Furthermore, this edition takes its discussion of biomarkers to the next level, exploring newer and related investigations, such as metabolomics/NMR and multiplex technology. Under the editorial guidance of G.O. Evans, a recognized field authority, the book presents background information on the selection and application of biochemical tests in preclinical safety assessment studies. It also assesses specific organ toxicity, such as in the liver, kidney, and thyroid, along with regulatory requirements and statistical approaches. Careful to avoid delving into overly complex detail, this text is a comprehensive, practical reference ideal for new entrants to the field. However, its broad scope and depth also make it suitable for more seasoned scientists and toxicologists.