Conceptual Design Of Crystallization Processes

The book presents, in a unified manner, various crystallization design methods. It discusses in detail the geometric framework for representing complex phase behavior involving multiple solutes, enantiomers, hydrates, compounds, polymorphs, and solid solutions through visualization of high-dimensional phase diagrams. It also describes how the impact of transport processes is accounted for using kinetically controlled process paths.

This text explains the concepts behind process design. It uses a case study approach, guiding readers through realistic design problems, and referring back to these cases at the end of each chapter. Throughout, the author uses shortcut techniques that allow engineers to obtain the whole focus for a design in a very short period (generally less than two days).

Crystallization is a natural occurring process but also a process abundantly used in the industry. Crystallization can occur from a solution, from the melt or via deposition of material from the gas phase (desublimation). Crystals distinguish themself from liquids, gases and amorphous substances by the long-range order of its building blocks that entail the crystals to be formed of well-defined faces, and give rise to a large number of properties of the solid. Crystallization is used at some stage in nearly all process industries as a method of production, purification or recovery of solid materials. Crystallization is practiced on all scales: from the isolation of the first milligrams of a newly synthesized substance in the research laboratory to isolating products on the mulit-million tonne scale in industry. The book describes the breadth of crystallization operations, from isolation from a reaction broth to purification and finally to tailoring product properties. In the first section of the book, the basic mechanisms - nucleation, growth, attrition and agglomeration are introduced. It ensures an understanding of supersaturation, the driving force of crystallization. Furthermore, the solubility of the substance and its dependences on process conditions and the various techniques of crystallization and their possibilities and limitations are discussed. Last but not least, the first part includes an intensive treatment of polymorphism . The second part builds on the basics, exploring how crystallization processes can be developed, either batch-wise or continuous, from solution or from the melt. A discussion of the purification during crystallization serves as a link between the two sections, where practical aspects and an insight using theoretical concepts are combined. Mixing and its influence on the crystallization as well as the mutual interference of down-stream processes with the crystallization are also treated. Finally, techniques to characterize the crop are discussed. The third part of the book is dedicated to accounts of actual developments and of carried-out crystallizations. Typical pitfalls and strategies to avoid these as well as the design of robust processes are presented.

Incorporating all recent developments and applications of crystallization technology, this volume offers a clear account of the field's underlying principles, reviews of past and current research, and provides guidelines for equipment and process design. The book takes a balanced functional approach in its critical survey of research literature, and includes several problems based on real practical situations that illustrate theoretical development. Several new concepts and techniques used in process simulation and identification analysis are featured.

The 18th European Symposium on Computer Aided Process Engineering contains papers presented at the 18th European Symposium of Computer Aided Process Engineering (ESCAPE 18) held in Lyon, France, from 1-4 June 2008.The ESCAPE series brings the latest innovations and achievements by leading professionals from the industrial and academic communities. The series serves as a forum for engineers, scientists, researchers, managers and students from academia and industry to:- present new computer aided methods, algorithms, techniques related to process and product engineering,- discuss innovative concepts, new challenges, needs and trends in the area of CAPE.This research area bridges fundamental sciences (physics, chemistry, thermodynamics, applied mathematics and computer sciences) with the various aspects of process and product engineering.The special theme for ESCAPE-18 is CAPE for the Users! CAPE systems are to be put in the hands of end users who need functionality and assistance beyond the scientific and technological capacities which are at the core of the systems. The four main topics are:- off-line systems for synthesis and design,- on-line systems for control and operation,- computational and numerical solutions strategies,- integrated and multi-scale modelling and simulation,Two general topics address the impact of CAPE tools and methods on Society and Education. * CD-ROM that accompanies the book contains all research papers and contributions* International in scope with guest speeches and keynote talks from leaders in science and industry* Presents papers covering the latest research, key top areas and developments in Computer Aided Process Engineering

Particulate Crystal Characteristics; Fluid-particle Transport Processes; Crystallization Principles and Techniques; Crystal Formation Processes; Crystallizer Design and Operation; Solid-Liquid Separation Processes; Design of Crystallization Process Systems.

26th European Symposium on Computer Aided Process Engineering contains the papers presented at the 26th European Society of Computer-Aided Process Engineering (ESCAPE) Event held at Portorož Slovenia, from June 12th to June 15th, 2016. Themes discussed at the conference include Process-product Synthesis, Design and Integration, Modelling, Numerical analysis, Simulation and Optimization, Process Operations and Control and Education in CAPE/PSE. Presents findings and discussions from the 26th European Society of Computer-Aided Process Engineering (ESCAPE) Event