Conformationally Directed Drug Design
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Structure Based Drug Design
Author | : Pandi Veerapandian |
Publsiher | : Routledge |
Total Pages | : 665 |
Release | : 2018-03-29 |
Genre | : Medical |
ISBN | : 9781351413060 |
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Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!
An Introduction to Drug Design
Author | : S. N. Pandeya,J. R. Dimmock |
Publsiher | : New Age International |
Total Pages | : 228 |
Release | : 1997 |
Genre | : Drugs |
ISBN | : 8122409431 |
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The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To Drug Discovery Are Considered. Similarly, There Have Been Major Advances In The Employment Of Computers In Structure-Activity Analysis, And A Discussion Of The State Of The Art In This Area Is Also Included.The Chapter On Qsar Highlights The Role Of Physico-Chemical Parameters In Predicting The Future Course Of Drug Discovery With Rational Drug Design. The Role Of Enzymes In Drug Action Is Well Established, And A Chapter On Design Of Enzyme Inhibitors Is Well Documented. In Addition, The Increased Understanding Of The Design And Utilisation Of Prodrugs Has Led To A Discussion Of The Relevant Issues In This Text.Thus The Book Will Fill The Need Of A Text For Designing New Drugs And The Principles Of New Drug Discovery.
Conformationally Directed Drug Design
Author | : Julius A. Vida,Maxwell Gordon,American Chemical Society. Division of Medicinal Chemistry |
Publsiher | : Unknown |
Total Pages | : 296 |
Release | : 1984 |
Genre | : Medical |
ISBN | : UOM:39015018156953 |
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The Organic Chemistry of Drug Design and Drug Action
Author | : Richard B. Silverman |
Publsiher | : Elsevier |
Total Pages | : 650 |
Release | : 2012-12-02 |
Genre | : Science |
ISBN | : 9780080513379 |
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Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
Annual Reports in Medicinal Chemistry
Author | : Anonim |
Publsiher | : Academic Press |
Total Pages | : 400 |
Release | : 1987-09-02 |
Genre | : Medical |
ISBN | : 9780080583662 |
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Annual Reports in Medicinal Chemistry
Rational Drug Design
Author | : Abby L. Parrill |
Publsiher | : Unknown |
Total Pages | : 408 |
Release | : 1999 |
Genre | : Mathematics |
ISBN | : UOM:39015042766082 |
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This book is an overview of current progress in drug design. It focuses on energetics of drug interactions with solvents and biomolecules, applications of traditional drug design methods, and related evolutionary algorithms.
Ant Colony Optimization
Author | : Marco Dorigo,Thomas Stutzle |
Publsiher | : MIT Press |
Total Pages | : 324 |
Release | : 2004-06-04 |
Genre | : Computers |
ISBN | : 0262042193 |
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An overview of the rapidly growing field of ant colony optimization that describes theoretical findings, the major algorithms, and current applications. The complex social behaviors of ants have been much studied by science, and computer scientists are now finding that these behavior patterns can provide models for solving difficult combinatorial optimization problems. The attempt to develop algorithms inspired by one aspect of ant behavior, the ability to find what computer scientists would call shortest paths, has become the field of ant colony optimization (ACO), the most successful and widely recognized algorithmic technique based on ant behavior. This book presents an overview of this rapidly growing field, from its theoretical inception to practical applications, including descriptions of many available ACO algorithms and their uses. The book first describes the translation of observed ant behavior into working optimization algorithms. The ant colony metaheuristic is then introduced and viewed in the general context of combinatorial optimization. This is followed by a detailed description and guide to all major ACO algorithms and a report on current theoretical findings. The book surveys ACO applications now in use, including routing, assignment, scheduling, subset, machine learning, and bioinformatics problems. AntNet, an ACO algorithm designed for the network routing problem, is described in detail. The authors conclude by summarizing the progress in the field and outlining future research directions. Each chapter ends with bibliographic material, bullet points setting out important ideas covered in the chapter, and exercises. Ant Colony Optimization will be of interest to academic and industry researchers, graduate students, and practitioners who wish to learn how to implement ACO algorithms.
Emerging Technologies and New Directions in Drug Abuse Research
Author | : Rao S. Rapaka,Alexandros Makriyannis,Michael J. Kuhar |
Publsiher | : Cultural Connections |
Total Pages | : 352 |
Release | : 1991 |
Genre | : Medical |
ISBN | : MINN:31951D00864773W |
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