Corneal Transplantation

This textbook reviews the novel techniques employed in corneal transplantation. It will assist fellows and corneal surgeons in using these techniques to best effect and in selecting patients for surgical procedures, taking into account the benefits and risks. Until 15 years ago the state-of-the art type of corneal transplantation was penetrating keratoplasty. Since the start of this millennium, however, important advances have been made in developing new surgical techniques. Today, the vast majority of keratoplasty procedures are performed as delicate lamellar procedures, either with the assistance of fine microkeratomes or femtosecond lasers or using very advanced surgical dissection procedures. Corneal Transplantation provides detailed information on these and other advances, which have helped patients undergoing keratoplasty to achieve a much faster visual recovery and a more stable eye with less risk of rejection episodes. ​

"DSEK: What You Need to Know About Endothelial Keratoplasty provides a comprehensive background of EK, where it is today, and where it is headed in the future. Francis W. Price, MD. who was the first to complete DSEK in the United States, along with Marianne Price, PhD, have designed this text to offer a special emphasis on how to perform surgeries along with preventing and managing complications. In addition, a diverse group of contributing authors provides a wide array of insights and tips for better patient outcomes."--BOOK JACKET.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

This book provides a summary of the various aspects of corneal transplantation — the clinical, experimental (including multimedia display of the surgical techniques), immunological, therapeutic and prosthetic components — in one volume. The interested specialist in one field can thus have access to information from the other fields and develop a broad concept of the challenges to be faced in achieving the ultimate goal, i.e. an optically clear, visually satisfactory, functioning corneal graft which is tolerated in the long term without the need for systemic immunosuppression. A second purpose of the book is to provide information regarding current immunological concepts of the process of corneal graft rejection. In particular, recent work in the fields of innate versus adaptive immunity, novel therapeutics and corneal xenografts is presented. Contents: A Brief History of Corneal TransplantationSurgery of Corneal Graft in HumansThe Clinical ProblemEye BankingMHC Antigens, Tissue Typing and Blood Group Matching in Corneal TransplantationThe Alloresponse to Corneal GraftThe Xenoresponse to Corneal GraftAnimal Models of Corneal GraftPathology of Human Corneal TransplantationTherapeutic Approach to Experimental Corneal Graft RejectionImmunosuppression for Human Corneal Graft RejectionTransmission of Disease Through Corneal TransplantationArtificial Corneas Readership: Researchers and practitioners in ophthalmology, optometry, immunology, transplantation and surgery. Key Features:Concise but comprehensive guidebook/handbookCurrent and translational informationNew concepts of rejection and toleranceMultimedia display of microsurgical techniqueKeywords:Corneal Transplantation;Immunology;Ophthalmology;Tissue;Rejection;Prosthetics;Corneal Graft

Until a few years ago, eye banks were only considered as centres for collecting and processing units of human donor eyes. However, eye banks in recent years have changed the process of current corneal transplantation. Although the very first corneal transplantation was conceptualised in the late 18th century, it has taken a century to develop methods and understand the role of human corneas in general. This book gives an insight of worldwide associations and their standard regulations in terms of corneal donations, processes and transplantations. The associations mainly include: Eye Bank Association of America, European Eye Bank Association and Eye Bank Association of Australia and New Zealand. This book also refers to some of the early stages of eye banking and current methods of preservation, including cold and organ culture storage. The current eye banking scenario is changing dramatically in terms of tissue processing. Once, tissues were only collected, stored and shipped for transplantation to the surgeons. Now eye banks have advanced in developing techniques in collaboration with surgeons to introduce more reliable methods of transplantation. This includes standardisation of methods such as DSAEK, UT-DSAEK, pre-loaded grafts and DMEK. Furthermore, this compilation describes different techniques of lamellar keratoplasty, such as anterior and posterior lamellar keratoplasties. Retrieving, storing, processing and transplantation of such lenticules are also discussed in this book. Posterior lamellar graft preparation for selective surgeries like DSAEK and Ultra-Thin DSAEK has been included with relevant clinical approaches. DMEK, which is currently taking corneal transplantation to a different level, has been reported with various graft preparation techniques. The role of eye banks in general for such preparation method is also examined. Additionally, the importance of microbiology in day to day care in the field of corneal transplantation and eye banks exists as a topic within these pages. Eye banks are playing a major role and changing the face of corneal transplantation in terms of new research; whether it be graft preparation for surgeries, preservation, surgical tools, ready-to-use tissues or studying cornea in details using available research tissues, these methods are advancing the field. Eye banks play a major role in tissue selection and correct processing methods. Surgeons are provided with a validated tissue so it makes easier for them to follow the transplantation. Therefore, this book highlights the new concepts in the eye banking field with regards to the standards, regulations, retrieval, preservation and transplantation methods. All of these continue to help aid in the research and development of surgical processes and devices.

Basic immunology relating to corneal graft rejection is presented in this book. All aspects of corneal graft rejection, from the historical perspective to the diagnosis, treatment and prevention of corneal graft rejection, are discussed. The author includes controversial topics such as the roles of systemic immunosuppressant agents and tissue matching.

The cornea is the clear, outer layer at the front of the eyeball. It acts as a window to the eye. The cornea helps to focus light rays onto the retina, this image is then transmitted to the brain. When the cornea is damaged, it can become less transparent or its shape can change. This can prevent light reaching the retina and causes the picture transmitted to the brain to be distorted or unclear. A corneal transplant, also known as keratoplasty or a corneal graft, is an operation to remove all or part of a damaged cornea and replace it with healthy donor tissue. It is used to improve sight, relieve pain and treat severe infection or damage. One of the most common reasons for a cornea transplant is a condition called keratoconus, which causes the cornea to change shape. (NHS.UK) This book is a guide to corneal transplantation (keratoplasty) for ophthalmic surgeons. Divided into seven sections, the text begins with an overview of evolution, preoperative considerations, and eye banking. The following sections cover a multitude of keratoplasty techniques, including endothelial keratoplasty, and their potential complications. The book concludes with discussion on alternatives to corneal transplantation. The third edition of this comprehensive manual has been fully revised, with new topics added, to provide surgeons with the latest advances in the field. A selection of operative videos can be accessed via a QR code provided in the book. The previous edition (9788184488593) published in 2010.