Development Of An Electrochemical Biosensor Platform And A Suitable Low Impedance Surface Modification Strategy

In this work, a flexible biosensor platform based on impedance spectroscopy and comprising of gold electrodes, polymeric flow cells and a suitable surface modification were developed. Initially, several surface modification techniques described in literature were implemented and optimized for impedimetric biosensors but their individual limitations rendered them unsuitable for this biosensor platform. A novel method based on photobleaching was developed and tested showing satisfactory results.

In this work, a flexible biosensor platform based on impedance spectroscopy and comprising of gold electrodes, polymeric flow cells and a suitable surface modification were developed. Initially, several surface modification techniques described in literature were implemented and optimized for impedimetric biosensors but their individual limitations rendered them unsuitable for this biosensor platform. A novel method based on photobleaching was developed and tested showing satisfactory results. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

New Frontiers in Nanochemistry: Concepts, Theories, and Trends, Volume 1: Structural Nanochemistry is the first volume of the new three-volume set that explains and explores the important concepts from various areas within the nanosciences. This first volume focuses on structural nanochemistry and encompasses the general fundamental aspects of nanochemistry while simultaneously incorporating crucial material from other fields, in particular mathematic and natural sciences, with specific attention to multidisciplinary chemistry. Under the broad expertise of the editor, the volume contains 50 concise yet comprehensive entries from world-renowned scholars, alphabetically organizing a multitude of essential basic and advanced concepts, ranging from algebraic chemistry to new energy technology, from the bondonic theory of chemistry to spintronics, and from fractal dimension and kinetics to quantum dots and tight binding—and much more. The entries contain definitions, short characterizations, uses and usefulness, limitations, references, and more.

New Frontiers in Nanochemistry: Concepts, Theories, and Trends, 3-Volume Set explains and explores the important fundamental and advanced modern concepts from various areas of nanochemistry and, more broadly, the nanosciences. This innovative and one-of-a kind set consists of three volumes that focus on structural nanochemistry, topological nanochemistry, and sustainable nanochemistry respectively, collectively forming an explicative handbook in nanochemistry. The compilation provides a rich resource that is both thorough and accessible, encompassing the core concepts of multiple areas of nanochemistry. It also explores the content through a trans-disciplinary lens, integrating the basic and advanced modern concepts in nanochemistry with various examples, applications, issues, tools, algorithms, and even historical notes on the important people from physical, quantum, theoretical, mathematical, and even biological chemistry.

This work offers three solutions tailored to specific applications to overcome NMR challenges in the micro-domain. As the first sub-topic of this work, different potential electrode designs, compatible with NMR technique, are suggested and experimentally evaluated. As the second focus point, this work tackles multinuclear detection challenges. In parallel, a low-cost, broadband insert is discussed to enhance the sensitivity of standard NMR coils when a small sample volume is available.

Inspired by superhydrophobic leaves of water plants, a flexible superhydrophobic self-cleaning, transparent thin polymeric nanofur film was fabricated through highly scalable hot embossing and hot pulling techniques. Nanofur can retain an air film underwater, whose stability against external stimuli such as high pressure and movement through fluids is investigated. Additionally, the optical properties of nanofur are investigated and exploited to enhance the efficiency of optoelectronic devices.

A new immobilization method for the localized adsorption of proteins on thermoplastic surfaces is introduced. Artificial three-phase interfaces were realized by surface structuring to control the wetting behavior which lead to a preferred adsorption in these modified areas. Additionally, different fabrication methods were analyzed to determine mass fabrication capabilities. These fabrication methods also allowed the production of fully structured microchannels to tune the fluids behavior within.