Diagnostic And Therapeutic Nuclear Medicine For Neuroendocrine Tumors

Based on the most novel approaches and cutting-edge clinical and scientific information regarding radionuclide imaging and therapies for neuroendocrine tumors, this clinical guidebook represents a unique collaborative effort between endocrinologists, nuclear physicians, oncologists, surgeons, physicists, radio-pharmacists and geneticists. It begins with the embryology, classification and molecular genetics of gastroenteropancreatic neuroendocrine tumors and carcinoids, chromaffin cell tumors, and MEN1- and MEN2-related tumors. Following a chapter on radiopharmaceuticals in neuroendocrine imaging, it turns to the physics and technology of current and cutting-edge radiology, including SPECT/CT and PET/CT and PET/MR. Discussing of radionuclide imaging covers the tumors mentioned above, as well as pulmonary and thymic neuroendocrine tumors and medullary thyroid carcinoma. A presentation of radionuclide therapies follows, including 131I-MIBG therapy, somatostatin receptor-based therapy, and alpha radionuclide therapy, as well as the role of nanoparticles. Comprehensive and up-to-date, Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors will assist and guide physicians who encounter patients with these conditions, either from a diagnostic or therapeutic standpoint, and particularly emphasizes the current and emerging medical devices and imaging and therapeutic options.

The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. This up-to-date, comprehensive book, written by world-renowned experts, discusses the basic principles of radionuclide therapy, explores in detail the available treatments, explains the regulatory requirements, and examines likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the role of the therapeutic nuclear physician in coordinating a diverse multidisciplinary team, which is central to the safe provision of treatment.

In medicine, endocrinology is perhaps the domain that encompasses the most molecular imaging using radioactive agents, also called radiopharmaceuticals. This is due to the diversity of molecular targets, including hormone synthesis pathways expressed uniquely by endocrine tumors and the growing knowledge in their pathophysiology and genetics. Those radiopharmaceuticals not only serve as diagnostic agents, but can also serve as a platform for characterizing endocrine disorders and treat patients and be used to monitor intracellular events that are induced by various therapies. Finally, they may be able to predict the aggressiveness and metastatic potential of endocrine tumors. This book provides comprehensive and up-to-date insights into the diagnostic, therapeutic, and future approaches of nuclear medicine to endocrine tumors in a new spirit of precision medicine. It will be of interest to practicing physicians, including nuclear medicine specialists, radiologists, endocrinologists, and oncologists, as well as fellows in training, students, and other health care professionals.

Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Nuclear Medicine, third edition, is an invaluable resource for nuclear medicine physicians, general radiologists, and trainees—anyone who requires an easily accessible, highly visual reference on today’s rapidly changing nuclear medicine therapies. Updated throughout, it addresses the most appropriate nuclear medicine options available to answer specific clinical questions within the framework of all imaging modalities, making this edition a useful learning tool as well as a handy reference for daily practice. Reflects recent advances in the field with information on new guidelines, new imaging protocols and equipment, and new radiotracers —including I-131 therapy for thyroid cancer; new tracers for PET/CT for prostate cancer, carcinoid tumor, pancreatic neuroendocrine tumors, and many more; new procedures for GI motility; new SPECT/CT protocols for sentinel lymph node mapping, parathyroid adenoma, pulmonary embolism, and more Contains new chapters on approach to nuclear medicine therapy, Lu-177 Dotatate therapy for SRS positive tumors, Lu-177 PSMA therapy for prostate cancer, GFR Analysis, pulmonary carcinoid tumor, meningioma, and pediatric CNS and neuroendocrine tumors Details new targeted nuclear medicine therapies, including theranostics: using one radioactive drug to diagnose and a second radioactive drug to deliver therapy to treat a main tumor and any metastatic tumors Features more than 1,500 high-quality images, many new or updated, including pediatric imaging, oncology imaging, radiology images, full-color drawings and illustrations, and 3D renderings Covers the physics behind nuclear medicine with safety considerations for both patients and radiologists Uses bulleted, succinct text and highly templated chapters to help you make informed decisions at the point of care

The diagnostic and therapeutic achievements in radiopharmaceuticals and nuclear medicine instrumentation - PET, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT - are the result of the interdisciplinary research efforts of cell-biologists, chemists, pharmacologists, physicists, computer-scientists, engineers, nuclear medicine physicians, a

This book presents up-to-date information on the general principles of diagnostic and therapeutic nuclear medicine in the context of endocrinology. The content is divided into six parts. Section I examines general aspects of radiopharmaceuticals, scintigraphy, single-photon emission computed tomography (SPECT), positron emission tomography (PET), radionuclide therapies and radioguided surgery. Section II discusses diagnostic applications in benign thyroid diseases and evaluation of thyroid nodules. Section III gives an overview of the management of parathyroid diseases. Section IV presents diagnostic techniques in well-differentiated thyroid cancer. Section V addresses procedures and therapy in adrenal benign and malignant disorders (phaechromocytomas and paragangliomas). Lastly, the diagnosis and treatment of neuroendocrine tumors are featured in Section VI. Nuclear Medicine in Endocrine Disorders: Diagnosis and Therapy is intended for non-specialists in nuclear medicine working in the field of endocrinology, and is also a valuable resource for researchers and students.

Nuclear Medicine Therapy presents the state of the art in targeted radionuclide therapy, both in clinical practice and contemporary clinical investigation and trials. With contributions from an internationally-distinguished group of physicians and scientists, the book is devoted entirely to the use of nuclear medicine techniques and technology for therapy of malignant and benign diseases. Individual chapters cover the scientific principles and clinical applications of radionuclide therapy and the state of clinical trials of agents currently under investigation in the therapy of tumors involving virtually every organ system. Due to overlapping interest in techniques, indications, and clinical use, the development of radionuclide therapy attracts considerable input from other medical specialists whose collaboration is essential, including radiation and medical oncologists, hematologists, diagnostic radiologists, hepatologists, endocrinologists, and rheumatologists. And because radionuclide therapy is a rapidly evolving field of nuclear medicine, it is the aim of this volume to appeal to all specialists involved in targeted radionuclide therapy and to contribute to the standardization of the practice globally.

This book provides the reader with a comprehensive understanding of both the basic principles and the clinical applications of nuclear oncology imaging techniques. The authors have assembled a distinguished group of leaders in the field who provide valuable insight on the subject. The book also includes major chapters on the cancer patient and the pathophysiology of abnormal tissue, the evaluation of co-existing disease, and the diagnosis and therapy of specific tumors using functional imaging studies. Each chapter is heavily illustrated to assist the reader in understanding the clinical role of nuclear oncology in cancer disease therapy and management.