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The Annual of scientific discovery or yearbook of facts in science and art
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 412 |
Release | : 1854 |
Genre | : Electronic Book |
ISBN | : DMM:057002562635 |
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Privileged Scaffolds in Drug Discovery
Author | : Bin Yu,Ning Li,Caiyun Fu |
Publsiher | : Elsevier |
Total Pages | : 988 |
Release | : 2023-07-19 |
Genre | : Medical |
ISBN | : 9780443186127 |
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Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. Provides wide coverage of privileged scaffolds in new drug discovery Includes complex and diverse natural product scaffolds Covers applications to peptides and peptide-based drugs
England and the Discovery of America 1481 1620
Author | : David B. Quinn |
Publsiher | : Taylor & Francis |
Total Pages | : 559 |
Release | : 2023-08-18 |
Genre | : History |
ISBN | : 9781000963809 |
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First published in 1974, England and the Discovery of America places the early explorations of the English in North America in the broad context of 15th and 16th century history. Marshalling evidence that cannot be pushed aside and sifting a mass of fascinating detail (including problems of cartography and the Vinland Map controversy), Professor Quinn presents circumstantial indications pointing to 1481 as the date or the discovery of America by Bristol voyagers – fishermen seeking new sources of cod, and merchant sailors with maps carrying promise of unexploited Atlantic islands. Whereas England did little to follow up her early lead, Quinn demonstrates that English initiatives from the 1580s onward, though slow, were of great importance. He brings to life the men involved in a variety of rash and heroic experiments in colonization and casts new light on their fates. He makes it clear that it was this very profusion of trial and error and trail again, as well as the conviction that settlement in temperate latitudes in North America could be effective if tenaciously enough sought, that enabled the English to strike and maintain routes in their new American world. This book will be of interest to students of English history, American history, colonial history and naval history.
Newly Discovered Gnostic Writings
Author | : Willem Cornelis Unnik |
Publsiher | : Unknown |
Total Pages | : 124 |
Release | : 1960 |
Genre | : Coptic manuscripts (Papyri) |
ISBN | : UOM:39015002785064 |
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Computational and Structural Approaches to Drug Discovery
Author | : Robert Stroud,Janet Finer-Moore |
Publsiher | : Royal Society of Chemistry |
Total Pages | : 400 |
Release | : 2007-10-31 |
Genre | : Science |
ISBN | : 9781847557964 |
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Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials... This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the factors that determine adsorption, distribution, metabolism, excretion and toxicology are explored, as they remain the critical issues in this area of research. This indispensable resource provides the reader with: * A rich understanding of modern approaches to docking * A comparison and critical evaluation of state-of-the-art methods * Details on harnessing computational methods for both analysis and prediction * An insight into prediction potencies and protocols for unbiased evaluations of docking and scoring algorithms * Critical reviews of current fragment based methods with perceptive applications to kinases Addressing a wide range of uses of protein structures for drug discovery the Editors have created and essential reference for professionals in the pharmaceutical industry and moreover an indispensable core text for all graduate level courses covering molecular interactions and drug discovery.
Soil Erosion and Stream Flow on Range and Forest Lands of the Upper Rio Grande Watershed in Relation to Land Resources and Human Welfare
Author | : Arthur Henry Joel,Charles Calvert Smoot,Charles Knesal Cooperrider,Clarence Sheldon Slater,Cyril Oliver Bratley,Eugenia Cuvillier,George Henry Hepting,George Luther Schnur,George W. Barber,George Wallace Musgrave,Harold Blaisdell Shepard,Herbert George Barott,James Stewart Wiant,James William Park,Lawrence Zeleny,Lewis Bertie Olmstead,Margaret Blanche Hays,Norman Julian Wall,Paul Lewis Harding,R. L. Piemeisel,R. W. Leukel,Stephen Harold Hastings,Stuart Bevier Show,William Henry Black,Barnard Andrew Hendricks,Dan Hansen,David Augustus Coleman,E. I. Kotok,Edwin Alfonso Trowbridge,F. F. Dicke,Francis Raymond Lawson,George Grant Hedgcock,Jacob Martin Lutz,Oscar Roland Mathews,R. S. Holmes,Ralph Wylie Frey,Robert Arthur Norton,J. I. Hardy,Dean Humboldt Rose,Horace Greeley Byers |
Publsiher | : Unknown |
Total Pages | : 1406 |
Release | : 1937 |
Genre | : Agricultural credit |
ISBN | : OSU:32435027441104 |
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Acta societatis regiae scientiarum Upsaliensis
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 566 |
Release | : 1870 |
Genre | : Electronic Book |
ISBN | : ONB:+Z229464100 |
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House documents
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 730 |
Release | : 1895 |
Genre | : Electronic Book |
ISBN | : BSB:BSB11799706 |
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