Effects Of Estradiol Progesterone And Caging With Males On Gonadotropin Surges In Middle Aged Female Rats Exhibiting Acyclicity And Early Persistant Estrus

​The objective of this book is to concisely present information with respect to appropriate use of experimental rodents in research. The principles elaborated seek to provide knowledge of the techniques involved in both management and scientific research to all who use laboratory animals, with a focus on the well-being and ethics regarding rodents and also to fortify the awareness of the importance of the animal as a study object and to offer orientation and assistance in conducting laboratory research, education or tests.

The manuscripts in this volume were contributed by the speakers invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The meeting was organized to commemorate the description of acromegaly by the French physician Pierre Marie, in 1886. The members of the Scientific Committee spent many hours assisting us in ensuring an outstanding meeting. The support of Serono Symposia, USA in all phases of the planning and execution of the meeting was sincerely appreciated and was highly professional. Special recognition roust be extended to Professor Roger Guillemin of the Salk Institute, whosp interest in medical history led him to devote a great deal of time and personal expense in obtaining information about the life of Pierre Marie. Dr. GuilIemin's presentation on the life and times of Marie was an extraordinary overview of the cultural, social, and scientific backgrounds in which Marie came to describe the disease, acromegaly. Dr. Guillemin' s findings, which were presented at the main banquet in a splendid audiovisual presentation, were clearly the highlight of the meeting and will long be remembered by the attendees. We were also honored by the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her address at the banquet, Dr. Granier provided several delightful and intimate vignettes concerning Pierre Marie, using old family records and photographs. The Scientific Committee wishes to extend its gratitude to Dr. Granier for adding immeasurably to the historical atmosphere of the meeting.

This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproducti

The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications Describes the angiogenic tree the mother’s uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success

This second edition emphasizes the environmental impact on reproduction, with updated chapters throughout as well as complete new chapters on species such as sharks and rays. This is a wide-ranging book that will be of relevance to anyone involved in species conservation, and provides critical perspectives on the real utility of current and emerging reproductive sciences. Understanding reproductive biology is centrally important to the way many of the world’s conservation problems should be tackled. Currently the extinction problem is huge, with up to 30% of the world’s fauna being expected to disappear in the next 50 years. Nevertheless, it has been estimated that the global population of animals in zoos encompasses 12,000 – 15,000 species, and we anticipate that every effort will be made to preserve these species for as long as possible, minimizing inbreeding effects and providing the best welfare standards available. Even if the reproductive biology community cannot solve the global biodiversity crisis for all wild species, we should do our best to maintain important captive populations. Reproductive biology in this context is much more than the development of techniques for helping with too little or too much breeding. While some of the relevant techniques are useful for individual species that society might target for a variety of reasons, whether nationalistic, cultural or practical, technical developments have to be backed up by thorough biological understanding of the background behind the problems.